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Edar
Gene Detail
Symbol

Name
ID
Edar
ectodysplasin-A receptor
MGI:1343498
Feature Type
protein coding gene
Genetic Map
Chromosome 10
29.37 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr10:58600789-58675654 bp, - strand
From VEGA annotation of GRCm38

  74866 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7699  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EDAR
Gene Tree: Edar

Human
homologs
EDAR, ectodysplasin A receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10913
neXtProt AC: NX_Q9UNE0

Human Synonyms: DL, ECTD10A, ECTD10B, ED1R, ED3, ED5, EDA1R, EDA3, EDA-A1R, HRM1

Human Chr (Location): 2q13; chr2:108894471-108989372 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human EDAR

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(2) Spontaneous(4) Targeted(4) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene produce abnormalities of the hair,teeth and some exocrine glands.
 
Human Diseases Modeled in Mice Using Edar (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Edar interacts with 244 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process apoptotic process, cell differentiation, ...
Component apical part of cell, integral component of membrane, ...
Function receptor activity
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (306)    Tissues (210)    Images (79)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 304
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA EDAR ; Xenbase edar ; ZFIN edar    NEW 
Molecular
reagents
All nucleic(27) Genomic(15) cDNA(9) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000025045 (Evidence)
Ensembl Gene Model ENSMUSG00000003227 (Evidence)
Entrez Gene 13608 (Evidence)
UniGene 174523
DFCI TC1742584, TC1627123, TC1592183
DoTS DT.55255277, DT.94228980
NIA Mouse Gene Index U031806
Consensus CDS Project CCDS23862.1
International Mouse Phenotyping Consortium Status Edar
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025045 VEGA Gene Model | MGI Sequence Detail 74866 C57BL/6J ±  kb
transcript OTTMUST00000061630 VEGA | MGI Sequence Detail 3637 Not Applicable 
polypeptide OTTMUSP00000030271 VEGA | MGI Sequence Detail 448 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(10) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(636 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
Protein Ontology PR:000006888 tumor necrosis factor receptor superfamily member EDAR
References
(Earliest) J:18293 Phillips RJS, New mutant. Mouse News Lett. 1960;23:29-30
(Latest) J:220362 Sun Y, et al., Trps1 deficiency inhibits the morphogenesis of secondary hair follicles via decreased Noggin expression. Biochem Biophys Res Commun. 2015 Jan 16;456(3):721-6
All references(120)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-8853, MGI:94898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory