Homozygous mutant mice lack plasmalogens due to inactivation of ether lipid synthesis. Mutant mice exhibit dwarfism, male infertility, defects in eye development, and optic nerve hypoplasia. While some mice die prematurely, others, particularly females, are long-lived.
|Process||cellular lipid metabolic process, cerebellum morphogenesis, ...|
|Component||membrane, mitochondrion, ...|
|Function||catalytic activity, glycerone-phosphate O-acyltransferase activity, ...|
|InterPro||IPR028353||Dihydroxyacetone phosphate acyltransferase|
|InterPro||IPR022284||Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase|
|Protein Ontology||PR:000008121||dihydroxyacetone phosphate acyltransferase|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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