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Gnpat
Gene Detail
Symbol

Name
ID
Gnpat
glyceronephosphate O-acyltransferase
MGI:1343460
Synonyms
D1Ertd819e
Feature Type
protein coding gene
Genetic Map
Chromosome 8
72.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:124863033-124890057 bp, + strand
From VEGA annotation of GRCm38

  27025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40716  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNPAT
Protein SuperFamily: glycerol-3-phosphate O-acyltransferase/dihydroxyacetone phosphate acyltransferase
Gene Tree: Gnpat

Human
homologs
GNPAT, glyceronephosphate O-acyltransferase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8443
neXtProt AC: NX_O15228

Human Synonyms: DAPAT, DAP-AT, DHAPAT

Human Chr (Location): 1q42; chr1:231241173-231277973 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GNPAT

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice lack plasmalogens due to inactivation of ether lipid synthesis. Mutant mice exhibit dwarfism, male infertility, defects in eye development, and optic nerve hypoplasia. While some mice die prematurely, others, particularly females, are long-lived.
 
Human Diseases Modeled in Mice Using Gnpat (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Gnpat interacts with 142 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cellular lipid metabolic process, cerebellum morphogenesis, ...
Component membrane, mitochondrion, ...
Function catalytic activity, glycerone-phosphate O-acyltransferase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (111)    Tissues (106)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 96
Northern blot 15
cDNA source data(174)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gnpat    NEW 
Molecular
reagents
All nucleic(175) cDNA(174) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031119 (Evidence)
Ensembl Gene Model ENSMUSG00000031985 (Evidence)
Entrez Gene 14712 (Evidence)
UniGene 29114
DFCI TC1572665, TC1777503, TC1714298, TC1769811
EC 2.3.1.42
Consensus CDS Project CCDS22776.1
International Mouse Phenotyping Consortium Status Gnpat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031119 VEGA Gene Model | MGI Sequence Detail 27025 C57BL/6J ±  kb
transcript OTTMUST00000077095 VEGA | MGI Sequence Detail 2984 Not Applicable 
polypeptide OTTMUSP00000040684 VEGA | MGI Sequence Detail 678 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(253 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022284 Glycerol-3-phosphate O-acyltransferase
InterPro IPR002123 Phospholipid/glycerol acyltransferase
Protein Ontology PR:000008121 dihydroxyacetone phosphate acyltransferase
References
(Earliest) J:56268 Ofman R, et al., Identification and characterization of the mouse cDNA encoding acyl-CoA:dihydroxyacetone phosphate acyltransferase. Biochim Biophys Acta. 1999 Jul 9;1439(1):89-94
(Latest) J:216821 Saab S, et al., Involvement of plasmalogens in post-natal retinal vascular development. PLoS One. 2014;9(6):e101076
All references(49)
Disease annotation references (1)
Other
accession IDs
MGI:1289284, MGI:2142692

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory