Gnpat
Gene Detail

Symbol Name ID

Gnpat glyceronephosphate O-acyltransferase MGI:1343460

Synonyms

D1Ertd819e

Feature Type

protein coding gene

Genetic Map

Chromosome 8

72.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:124863033-124890057 bp, + strand From VEGA annotation of GRCm38   27025 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40716  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: glycerol-3-phosphate O-acyltransferase/dihydroxyacetone phosphate acyltransferase
Gene Tree: Gnpat

Human homologs

Human Homolog		GNPAT, glyceronephosphate O-acyltransferase
NCBI Gene ID		8443
neXtProt AC		NX_O15228
Human Synonyms		DAPAT, DAP-AT, DHAPAT
Human Chr (Location)		1q42; chr1:231376919-231413719 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GNPAT

Alleles and phenotypes

All alleles(15) : Targeted(3) Gene trapped(12)
 

Homozygous mutant mice lack plasmalogens due to inactivation of ether lipid synthesis. Mutant mice exhibit dwarfism, male infertility, defects in eye development, and optic nerve hypoplasia. While some mice die prematurely, others, particularly females, are long-lived.

 
Human Diseases Modeled Using Mouse Gnpat (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	cellular lipid metabolic process, cellular membrane organization, ...
Component	membrane, mitochondrion, ...
Function	catalytic activity, glycerol-3-phosphate O-acyltransferase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (111)    Tissues (104)    Images (19)
Theiler Stages: 15, 19, 22, 23, 26, 28

Assay Type	Results
RNA in situ	96
Northern blot	15

cDNA source data(173)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(174) cDNA(173) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000031119 (Evidence)
Ensembl Gene Model	ENSMUSG00000031985 (Evidence)
Entrez Gene	14712 (Evidence)
UniGene	29114
DFCI	TC1572665, TC1714298, TC1769811, TC1777503
EC	2.3.1.42
Consensus CDS Project	CCDS22776.1
International Mouse Knockout Project Status	Gnpat

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031119	VEGA Gene Model | MGI Sequence Detail	27025	C57BL/6J
transcript	OTTMUST00000077095	VEGA | MGI Sequence Detail	2984	Not Applicable
polypeptide	OTTMUSP00000040684	VEGA | MGI Sequence Detail	678	Not Applicable

All sequences(65) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(152 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR022284	Glycerol-3-phosphate O-acyltransferase
InterPro	IPR002123	Phospholipid/glycerol acyltransferase
Protein Ontology	PR:000008121	dihydroxyacetone phosphate acyltransferase

References

(Earliest) J:56268 Ofman R, et al., Identification and characterization of the mouse cDNA encoding acyl-CoA:dihydroxyacetone phosphate acyltransferase. Biochim Biophys Acta. 1999 Jul 9;1439(1):89-94
(Latest) J:185375 Facciotti F, et al., Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nat Immunol. 2012 May;13(5):474-80
All references(47)

Other accession IDs

MGI:1289284, MGI:2142692