About   Help   FAQ
Gnpat
Gene Detail
 Symbol
Name
ID
Gnpat
glyceronephosphate O-acyltransferase
MGI:1343460
Synonyms D1Ertd819e
Feature Type protein coding gene
Genetic Map
Chromosome 8
72.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:124863033-124890057 bp, + strand
From VEGA annotation of GRCm38

  27025 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40716  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: glycerol-3-phosphate O-acyltransferase/dihydroxyacetone phosphate acyltransferase
Gene Tree: Gnpat

Human
homologs
Human Homolog GNPAT, glyceronephosphate O-acyltransferase
NCBI Gene ID 8443
neXtProt AC  NX_O15228
Human Synonyms  DAPAT, DAP-AT, DHAPAT
Human Chr (Location)  1q42; chr1:231241173-231277973 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human GNPAT
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice lack plasmalogens due to inactivation of ether lipid synthesis. Mutant mice exhibit dwarfism, male infertility, defects in eye development, and optic nerve hypoplasia. While some mice die prematurely, others, particularly females, are long-lived.
 
Human Diseases Modeled Using Mouse Gnpat (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Gnpat interacts with 142 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cellular lipid metabolic process, cerebellum morphogenesis, ...
Component membrane, mitochondrion, ...
Function catalytic activity, glycerone-phosphate O-acyltransferase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (111)    Tissues (106)    Images (19)
Theiler Stages: 15, 19, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 96
Northern blot 15
cDNA source data(174)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(175) cDNA(174) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031119 (Evidence)
Ensembl Gene ModelENSMUSG00000031985 (Evidence)
Entrez Gene14712 (Evidence)
UniGene29114
DFCITC1572665, TC1714298, TC1769811, TC1777503
EC2.3.1.42
Consensus CDS ProjectCCDS22776.1
International Mouse Knockout Project StatusGnpat
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031119 VEGA Gene Model | MGI Sequence Detail 27025 C57BL/6J ±  kb
transcript OTTMUST00000077095 VEGA | MGI Sequence Detail 2984 Not Applicable 
polypeptide OTTMUSP00000040684 VEGA | MGI Sequence Detail 678 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(2) UniProt(7)
Polymorphisms SNPs within 2kb(253 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022284 Glycerol-3-phosphate O-acyltransferase
InterPro IPR002123 Phospholipid/glycerol acyltransferase
Protein Ontology PR:000008121 dihydroxyacetone phosphate acyltransferase
References (Earliest) J:56268 Ofman R, et al., Identification and characterization of the mouse cDNA encoding acyl-CoA:dihydroxyacetone phosphate acyltransferase. Biochim Biophys Acta. 1999 Jul 9;1439(1):89-94
(Latest) J:185375 Facciotti F, et al., Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nat Immunol. 2012 May;13(5):474-80
All references(48)
Disease annotation references (1)
Other
accession IDs
MGI:1289284, MGI:2142692

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory