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Cdc45 Gene Detail
Summary
  • Symbol
    Cdc45
  • Name
    cell division cycle 45
  • Synonyms
    Cdc45l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338073
    NCBI Gene: 12544
  • Gene Overview
    MyGene.info: CDC45
Location & Maps
more
  • Sequence Map
    Chr16:18780447-18811987 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31541 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.63 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CDC45, cell division cycle 45
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDC45, cell division cycle 45
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDC45L, CDC45L2, MGORS7, PORC-PI-1
  • Links
    NCBI Gene ID: 8318
    neXtProt AC: NX_O75419

  • Chr Location
    22q11.21; chr22:19479385-19520612 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human CDC45 associations

Human Disease Mouse Models
       Meier-Gorlin Syndrome 7; MGORS7   OMIM: 617063
Click on a disease name to see all genes associated with that disease.

  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Gene trapped
    9
  • Targeted
    9
  • Genomic Mutations
    5 involving Cdc45
  • Incidental Mutations
Homozygous mutant embryos do not develop after implantation, resulting in embryonic lethality between E4.5-E5.5. Heterozygous animals appear normal and fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026176 VEGA Gene Model | MGI Sequence Detail 31541 C57BL/6J ±  kb
transcript OTTMUST00000064673 VEGA | MGI Sequence Detail 2143 Not Applicable  
polypeptide OTTMUSP00000032150 VEGA | MGI Sequence Detail 566 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    99 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000005215 CDC45-related protein
  • InterPro Domains
    IPR003874 CDC45 family
Molecular
Reagents
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  • All nucleic 31
    Genomic 13
    cDNA 12
    Primer pair 6

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 14
    Diseases 9
    Gene Ontology 3
    Phenotypes 33
  • Earliest
    J:49568 McKie JM, et al., Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. Genome Res. 1998 Aug;8(8):834-41
  • Latest
    J:213451 Karpinski BA, et al., Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome. Dis Model Mech. 2014 Feb;7(2):245-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory