About   Help   FAQ
Cdc45 Gene Detail
Summary
  • Symbol
    Cdc45
  • Name
    cell division cycle 45
  • Synonyms
    Cdc45l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338073
    NCBI Gene: 12544
  • Gene Overview
    MyGene.info: CDC45
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18780447-18811987 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.63 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    99 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338073
protein coding gene Chr16:18780447-18811992 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022618
protein coding gene Chr16:16036413-16073971 (-)
A/J MGP_AJ_G0022579
protein coding gene Chr16:15236198-15269031 (-)
AKR/J MGP_AKRJ_G0022556
protein coding gene Chr16:15852473-15886712 (-)
BALB/cJ MGP_BALBcJ_G0022584
protein coding gene Chr16:15388344-15420256 (-)
C3H/HeJ MGP_C3HHeJ_G0022351
protein coding gene Chr16:16004201-16038663 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023033
protein coding gene Chr16:16354705-16393494 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020553
protein coding gene Chr16:15272396-15303205 (-)
CAST/EiJ MGP_CASTEiJ_G0021878
protein coding gene Chr16:15906311-15936730 (-)
CBA/J MGP_CBAJ_G0022320
protein coding gene Chr16:17032057-17062926 (-)
DBA/2J MGP_DBA2J_G0022452
protein coding gene Chr16:15148400-15180451 (-)
FVB/NJ MGP_FVBNJ_G0022427
protein coding gene Chr16:15212292-15244864 (-)
LP/J MGP_LPJ_G0022519
protein coding gene Chr16:15789287-15821729 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022449
protein coding gene Chr16:16667277-16702475 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023044
protein coding gene Chr16:15770909-15805556 (-)
PWK/PhJ MGP_PWKPhJ_G0021620
protein coding gene Chr16:15444531-15475521 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021447
protein coding gene Chr16:15691936-15764440 (-)
WSB/EiJ MGP_WSBEiJ_G0021924
protein coding gene Chr16:15797835-15830466 (-)



Homology
more
  • Human Ortholog
    CDC45, cell division cycle 45
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDC45, cell division cycle 45
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDC45L, CDC45L2, MGORS7, PORC-PI-1
  • Links
    NCBI Gene ID: 8318
    neXtProt AC: NX_O75419
    UniProt: O75419

  • Chr Location
    22q11.21; chr22:19479278-19520612 (+)  GRCh38.p7

Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant embryos do not develop after implantation, resulting in embryonic lethality between E4.5-E5.5. Heterozygous animals appear normal and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000000028 Ensembl Gene Model | MGI Sequence Detail 31541 C57BL/6J ±  kb
transcript ENSMUST00000000028 Ensembl | MGI Sequence Detail 2143 Not Applicable  
polypeptide ENSMUSP00000000028 Ensembl | MGI Sequence Detail 566 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    Genomic 13
    cDNA 13
    Primer pair 6

    Microarray probesets 3
References
more
  • Summaries
    All 74
    Developmental Gene Expression 15
    Diseases 3
    Gene Ontology 4
    Phenotypes 41
  • Earliest
    J:49568 McKie JM, et al., Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. Genome Res. 1998 Aug;8(8):834-41
  • Latest
    J:263198 Moutin E, et al., Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome. Cereb Cortex. 2017 Jul 1;27(7):3618-3629

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/13/2018
MGI 6.13
The Jackson Laboratory