About   Help   FAQ
Cdc45
Gene Detail
 Symbol
Name
ID
Cdc45
cell division cycle 45
MGI:1338073
Synonyms Cdc45l
Feature Type protein coding gene
Genetic Map
Chromosome 16
11.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:18780447-18811987 bp, - strand
From VEGA annotation of GRCm38

  31541 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2616  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cell division control protein 45
Gene Tree: Cdc45

Human
homologs
Human Homolog CDC45, cell division cycle 45
NCBI Gene ID 8318
neXtProt AC  NX_O75419
Human Synonyms  CDC45L, CDC45L2, PORC-PI-1
Human Chr (Location)  22q11.21; chr22:19479479-19520612 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(9) Targeted(7)
Genomic Mutations involving Cdc45 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant embryos do not develop after implantation, resulting in embryonic lethality between E4.5-E5.5. Heterozygous animals appear normal and fertile.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Cdc45 interacts with 38 markers (Mir23a, Mir23b, Mir138-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cell cycle, cell division, ...
Component centrosome, nucleus
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (187)    Tissues (94)    Images (44)
Theiler Stages: 12, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 133
RT-PCR 47
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(13) cDNA(12) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026176 (Evidence)
Ensembl Gene ModelENSMUSG00000000028 (Evidence)
Entrez Gene12544 (Evidence)
DFCITC1577345, TC1636791
NIA Mouse Gene IndexU036865
Consensus CDS ProjectCCDS28027.1, CCDS49788.1
International Mouse Knockout Project StatusCdc45
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026176 VEGA Gene Model | MGI Sequence Detail 31541 C57BL/6J ±  kb
transcript OTTMUST00000064673 VEGA | MGI Sequence Detail 2143 Not Applicable 
polypeptide OTTMUSP00000032150 VEGA | MGI Sequence Detail 566 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(12) UniProt(5)
Polymorphisms SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003874 CDC45 family
Protein Ontology PR:000005215 CDC45-related protein
References (Earliest) J:49568 McKie JM, et al., Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. Genome Res. 1998 Aug;8(8):834-41
(Latest) J:191130 Maynard TM, et al., 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory