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Cdc45
Gene Detail
Symbol

Name
ID
Cdc45
cell division cycle 45
MGI:1338073
Synonyms
Cdc45l
Feature Type
protein coding gene
Genetic Map
Chromosome 16
11.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:18780447-18811987 bp, - strand
From VEGA annotation of GRCm38

  31541 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2616  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDC45
Protein SuperFamily: cell division control protein 45
Gene Tree: Cdc45

Human
homologs
CDC45, cell division cycle 45
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8318
neXtProt AC: NX_O75419

Human Synonyms: CDC45L, CDC45L2, PORC-PI-1

Human Chr (Location): 22q11.21; chr22:19479385-19520612 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(9) Targeted(9)
Genomic Mutations involving Cdc45 (5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant embryos do not develop after implantation, resulting in embryonic lethality between E4.5-E5.5. Heterozygous animals appear normal and fertile.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Cdc45 interacts with 38 markers (Mir23a, Mir23b, Mir138-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cell cycle, DNA duplex unwinding, ...
Component centrosome, DNA replication preinitiation complex, ...
Function 3'-5' DNA helicase activity, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (188)    Tissues (97)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 133
RT-PCR 47
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cdc45 ; ZFIN cdc45    NEW 
Molecular
reagents
All nucleic(31) Genomic(13) cDNA(12) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000026176 (Evidence)
Ensembl Gene Model ENSMUSG00000000028 (Evidence)
Entrez Gene 12544 (Evidence)
DFCI TC1636791, TC1577345
NIA Mouse Gene Index U036865
Consensus CDS Project CCDS28027.1, CCDS49788.1
International Mouse Phenotyping Consortium Status Cdc45
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026176 VEGA Gene Model | MGI Sequence Detail 31541 C57BL/6J ±  kb
transcript OTTMUST00000064673 VEGA | MGI Sequence Detail 2143 Not Applicable 
polypeptide OTTMUSP00000032150 VEGA | MGI Sequence Detail 566 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(12) UniProt(5)
Polymorphisms
SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003874 CDC45 family
Protein Ontology PR:000005215 CDC45-related protein
References
(Earliest) J:49568 McKie JM, et al., Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene. Genome Res. 1998 Aug;8(8):834-41
(Latest) J:213451 Karpinski BA, et al., Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome. Dis Model Mech. 2014 Feb;7(2):245-57
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory