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G0s2 Gene Detail
Summary
  • Symbol
    G0s2
  • Name
    G0/G1 switch gene 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316737
    NCBI Gene: 14373
Location & Maps
more
  • Sequence Map
    Chr1:193272161-193273217 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1057 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 97.69 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    G0S2, G0/G1 switch 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    G0S2, G0/G1 switch 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 50486
    neXtProt AC: NX_P27469

  • Chr Location
    1q32.2; chr1:209675325-209676390 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit enhanced adipose lipolysis, altered hepatic energy balance and improved high fat diet induced liver steatosis and glucose homeostasis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050857 VEGA Gene Model | MGI Sequence Detail 1057 C57BL/6J ±  kb
transcript OTTMUST00000128865 VEGA | MGI Sequence Detail 871 Not Applicable  
polypeptide OTTMUSP00000069298 VEGA | MGI Sequence Detail 103 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    54 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031459 G0/G1 switch protein 2
  • InterPro Domains
    IPR016821 G0/G1 switch protein 2
Molecular
Reagents
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  • All nucleic 85
    cDNA 85

    Microarray probesets 3
Other
Accession IDs
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MGI:2138179, MGI:2138512
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:51222 Bachner D, et al., Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2). Dev Dyn. 1998 Dec;213(4):398-411
  • Latest
    J:219653 El-Assaad W, et al., Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice. Diabetologia. 2015 Jan;58(1):149-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory