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Cacng2 Gene Detail
Summary
  • Symbol
    Cacng2
  • Name
    calcium channel, voltage-dependent, gamma subunit 2
  • Synonyms
    B230105C07Rik, B930041E13Rik, stargazin, TARP gamma 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316660
    NCBI Gene: 12300
  • Gene Overview
    MyGene.info: CACNG2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr15:77991748-78120028 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      128281 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.92 cM
  • Mapping Data
    13 experiments
Homology
more
  • Human Ortholog
    CACNG2, calcium voltage-gated channel auxiliary subunit gamma 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CACNG2, calcium voltage-gated channel auxiliary subunit gamma 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRD10
  • Links
    NCBI Gene ID: 10369
    neXtProt AC: NX_Q9Y698
    UniProt: Q9Y698

  • Chr Location
    22q12.3; chr22:36560869-36702645 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CACNG2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 6 alleles in 8 genetic backgrounds
    14 phenotypes from multigenic genotypes
    3 images
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for mutant alleles show growth retardation, movement anomalies including ataxic gait, tremor and head tossing, and neocortical spike-wave seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016425 VEGA Gene Model | MGI Sequence Detail 128281 C57BL/6J ±  kb
    transcript OTTMUST00000039555 VEGA | MGI Sequence Detail 5510 Not Applicable  
    polypeptide OTTMUSP00000017670 VEGA | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      661 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 4
      cDNA 22
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-14624, MGD-MRK-15425, MGI:1925228, MGI:2146187, MGI:98432
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 15
      Phenotypes 86
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:256112 Lu HW, et al., Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters. Neuron. 2017 Sep 27;96(1):73-80.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory