Cacng2
Gene Detail

Symbol Name ID

Cacng2 calcium channel, voltage-dependent, gamma subunit 2 MGI:1316660

Synonyms

B230105C07Rik, B930041E13Rik, stargazin, TARP gamma 2

Feature Type

protein coding gene

Genetic Map

Chromosome 15

36.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr15:77991748-78120028 bp, - strand From VEGA annotation of GRCm38   128281 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4432  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cacng2

Human homologs

Human Homolog		CACNG2, calcium channel, voltage-dependent, gamma subunit 2
NCBI Gene ID		10369
neXtProt AC		NX_Q9Y698
Human Synonyms		MRD10
Human Chr (Location)		22q13.1; chr22:36956916-37098690 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CACNG2

Alleles and phenotypes

All alleles(27) : Targeted(5) Gene trapped(19) Spontaneous(3)
 

Homozygotes for mutant alleles show growth retardation, movement anomalies including ataxic gait, tremor and head tossing, and neocortical spike-wave seizures.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, integral to membrane, ...
Function	calcium channel activity, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (34)    Tissues (24)    Images (3)
Theiler Stages: 17, 20, 22, 23, 25, 28

Assay Type	Results
RNA in situ	24
RT-PCR	10

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(4) cDNA(20) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000016425 (Evidence)
Ensembl Gene Model	ENSMUSG00000019146 (Evidence)
Entrez Gene	12300 (Evidence)
NIA Mouse Gene Index	U036376, U197635
Consensus CDS Project	CCDS27608.1
International Mouse Knockout Project Status	Cacng2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016425	VEGA Gene Model | MGI Sequence Detail	128281	C57BL/6J
transcript	OTTMUST00000039555	VEGA | MGI Sequence Detail	5510	Not Applicable
polypeptide	OTTMUSP00000017670	VEGA | MGI Sequence Detail	323	Not Applicable

All sequences(29) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(2) : SNPs(504 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004031	PMP-22/EMP/MP20/Claudin
InterPro	IPR005422	Voltage-dependent calcium channel, gamma-2 subunit
InterPro	IPR008368	Voltage-dependent calcium channel, gamma subunit
Protein Ontology	PR:000004951	voltage-dependent calcium channel gamma-2 subunit

References

(Earliest) J:11008 Noebels JL, et al., Stargazer: a new neurological mutant on chromosome 15 in the mouse with prolonged cortical seizures [published erratum appears in Epilepsy Res 1992 Mar;11(1):72]. Epilepsy Res. 1990 Nov;7(2):129-35
(Latest) J:192431 Barad Z, et al., Selective loss of AMPA receptors at corticothalamic synapses in the epileptic stargazer mouse. Neuroscience. 2012 Aug 16;217:19-31
All references(110)

Other accession IDs

MGD-MRK-14624, MGD-MRK-15425, MGI:1925228, MGI:2146187, MGI:98432