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Cacng2 Gene Detail
Summary
  • Symbol
    Cacng2
  • Name
    calcium channel, voltage-dependent, gamma subunit 2
  • Synonyms
    B230105C07Rik, B930041E13Rik, stargazin, TARP gamma 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316660
    NCBI Gene: 12300
  • Gene Overview
    MyGene.info: CACNG2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:77991919-78119474 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 36.92 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    660 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316660
protein coding gene Chr15:77991748-78120028 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022035
protein coding gene Chr15:78145985-78279198 (-)
A/J MGP_AJ_G0021995
protein coding gene Chr15:75423381-75552771 (-)
AKR/J MGP_AKRJ_G0021972
protein coding gene Chr15:77502982-77629637 (-)
BALB/cJ MGP_BALBcJ_G0022003
protein coding gene Chr15:75436852-75567531 (-)
C3H/HeJ MGP_C3HHeJ_G0021774
protein coding gene Chr15:77580787-77707198 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022445
protein coding gene Chr15:81220710-81354876 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019974
protein coding gene Chr15:71991906-72118782 (-)
CAST/EiJ MGP_CASTEiJ_G0021294
protein coding gene Chr15:78180250-78315459 (-)
CBA/J MGP_CBAJ_G0021739
protein coding gene Chr15:83721054-83866027 (-)
DBA/2J MGP_DBA2J_G0021867
protein coding gene Chr15:74920374-75048605 (-)
FVB/NJ MGP_FVBNJ_G0021846
protein coding gene Chr15:73910637-74040632 (-)
LP/J MGP_LPJ_G0021936
protein coding gene Chr15:78325286-78452272 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021866
protein coding gene Chr15:88919454-89055381 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022459
protein coding gene Chr15:77603579-77734710 (-)
PWK/PhJ MGP_PWKPhJ_G0021036
protein coding gene Chr15:74901027-75032183 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020872
protein coding gene Chr15:77352249-77497186 (-)
WSB/EiJ MGP_WSBEiJ_G0021347
protein coding gene Chr15:77916972-78054285 (-)



Homology
more
  • Human Ortholog
    CACNG2, calcium voltage-gated channel auxiliary subunit gamma 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CACNG2, calcium voltage-gated channel auxiliary subunit gamma 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MRD10
  • Links
    NCBI Gene ID: 10369
    neXtProt AC: NX_Q9Y698
    UniProt: Q9Y698

  • Chr Location
    22q12.3; chr22:36560869-36702645 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human CACNG2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 6 alleles in 8 genetic backgrounds
    14 phenotypes from multigenic genotypes
    3 images
    88 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for mutant alleles show growth retardation, movement anomalies including ataxic gait, tremor and head tossing, and neocortical spike-wave seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12300 NCBI Gene Model | MGI Sequence Detail 127556 C57BL/6J ±  kb
    transcript NM_007583 RefSeq | MGI Sequence Detail 2887 Not Specified  
    polypeptide O88602 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 4
      cDNA 22
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-14624, MGD-MRK-15425, MGI:1925228, MGI:2146187, MGI:98432
    References
    more
    • Summaries
      All 150
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 19
      Phenotypes 88
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:263718 Meyer J, et al., Asynchronous suppression of visual cortex during absence seizures in stargazer mice. Nat Commun. 2018 May 16;9(1):1938

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory