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crsp Gene Detail
Summary
  • Symbol
    crsp
  • Name
    cryptorchidism with white spotting, deletion region
  • Feature Type
    heritable phenotypic marker
  • IDs
    MGI:1313307
    NCBI Gene: 12948
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 5, Syntenic
  • Mapping Data
    2 experiments
Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a deletion caused by random insertion of a tyrosinase expressing transgene exhibit partial postnatal lethality, variable white spotting, cryptorchism, arrest of spermatogenesis, azoospermia, and male infertility.
Expression
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  • cDNA Data
Sequences &
Gene Models
less
Polymorphisms
less
  • PCR
Molecular
Reagents
less
  • All nucleic 2
    cDNA 1
    Primer pair 1
References
more
  • Summaries
    All 13
    Diseases 1
    Phenotypes 9
  • Earliest
    J:134392 Zhao S, et al., Tyrosinase-related protein 2 promoter targets transgene expression to ocular and neural crest-derived tissues. Dev Biol. 1999 Dec 1;216(1):154-63
  • Latest
    J:194006 Huang Z, et al., Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice. Biol Reprod. 2012;87(6):143

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory