About   Help   FAQ
Tpst2 Gene Detail
Summary
  • Symbol
    Tpst2
  • Name
    protein-tyrosine sulfotransferase 2
  • Synonyms
    D5Ucla3, grm, grt, Tango13b
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309516
    NCBI Gene: 22022
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:112276691-112315361 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 54.65 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309516
protein coding gene Chr5:112276682-112315361 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029902
protein coding gene Chr5:114849948-114892110 (+)
A/J MGP_AJ_G0029868
protein coding gene Chr5:110379332-110418824 (+)
AKR/J MGP_AKRJ_G0029806
protein coding gene Chr5:113885957-113924599 (+)
BALB/cJ MGP_BALBcJ_G0029879
protein coding gene Chr5:111738303-111779171 (+)
C3H/HeJ MGP_C3HHeJ_G0029599
protein coding gene Chr5:114327548-114368533 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030332
protein coding gene Chr5:119337489-119383204 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027561
protein coding gene Chr5:105203072-105241427 (+)
CAST/EiJ MGP_CASTEiJ_G0029007
protein coding gene Chr5:113226951-113270078 (+)
CBA/J MGP_CBAJ_G0029566
protein coding gene Chr5:123814622-123859189 (+)
DBA/2J MGP_DBA2J_G0029716
protein coding gene Chr5:110445546-110485588 (+)
FVB/NJ MGP_FVBNJ_G0029673
protein coding gene Chr5:109168151-109209713 (+)
LP/J MGP_LPJ_G0029804
protein coding gene Chr5:115417757-115459286 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029704
protein coding gene Chr5:128393631-128436679 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030373
protein coding gene Chr5:113320302-113359235 (+)
PWK/PhJ MGP_PWKPhJ_G0028721
protein coding gene Chr5:109054324-109094212 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028559
protein coding gene Chr5:110806341-110844720 (+)
WSB/EiJ MGP_WSBEiJ_G0029083
protein coding gene Chr5:113833234-113875944 (+)



Homology
more
  • Human Ortholog
    TPST2, tyrosylprotein sulfotransferase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TPST2, tyrosylprotein sulfotransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TANGO13B, TPST-2
  • Links
    NCBI Gene ID: 8459
    neXtProt AC: NX_O60704
    UniProt: O60704

  • Chr Location
    22q12.1; chr22:26524082-26590125 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2666
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TPST2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Spontaneous mutants show a delayed rise and a prolonged deficit of pituitary growth hormone resulting in delayed pubertal growth, hypothyroidism, and an enlarged adenohypophysis with aberrant chromophobic cells. Homozygous null mice show a modest but transient pubertal growth lag and male sterility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029344 Ensembl Gene Model | MGI Sequence Detail 38671 C57BL/6J ±  kb
transcript ENSMUST00000031287 Ensembl | MGI Sequence Detail 1835 Not Applicable  
polypeptide ENSMUSP00000031287 Ensembl | MGI Sequence Detail 390 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 78
    Genomic 1
    cDNA 76
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16734, MGD-MRK-7379, MGI:2140887, MGI:93474, MGI:99932
References
more
  • Summaries
    All 64
    Gene Ontology 5
    Phenotypes 30
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:233605 Sawada K, et al., Regional hypoplasia of somatosensory cortex in growth-retarded mice (grt/grt). Congenit Anom (Kyoto). 2016 Jul;56(4):180-3

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/16/2019
MGI 6.13
The Jackson Laboratory