Ubr1
Gene Detail

Symbol Name ID

Ubr1 ubiquitin protein ligase E3 component n-recognin 1 MGI:1277977

Synonyms

E3 alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 2

60.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr2:120860269-120970715 bp, - strand From VEGA annotation of GRCm38   110447 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7582  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ubr1

Human homologs

Human Homolog		UBR1, ubiquitin protein ligase E3 component n-recognin 1
NCBI Gene ID		197131
neXtProt AC		NX_Q8IWV7
Human Synonyms		JBS
Human Chr (Location)		15q13; chr15:43235095-43398286 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human UBR1

Alleles and phenotypes

All alleles(14) : Targeted(3) Gene trapped(11)
 

Homozygous null mutants have 20% lower body weight and reduced muscle and adipose tissue. Skeletal muscle lacks a mechanism for targeting proteins for rapid catabolism. Aberrant regulation of fatty acid synthase upon starvation is also observed.

 
Human Diseases Modeled Using Mouse Ubr1 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	cellular response to leucine, negative regulation of TOR signaling cascade, ...
Component	cytoplasm, proteasome complex, ...
Function	leucine binding, ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (104)    Tissues (102)   
Theiler Stages: 17, 19, 22, 28

Assay Type	Results
RNA in situ	100
Northern blot	4

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(2) cDNA(25) Primer pair(1) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000015780 (Evidence)
Ensembl Gene Model	ENSMUSG00000027272 (Evidence)
Entrez Gene	22222 (Evidence)
DFCI	TC1581298, TC1604268, TC1616683, TC1630439
NIA Mouse Gene Index	U023252
EC	6.3.2.-
Consensus CDS Project	CCDS16628.1
International Mouse Knockout Project Status	Ubr1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015780	VEGA Gene Model | MGI Sequence Detail	110447	C57BL/6J
transcript	OTTMUST00000037499	VEGA | MGI Sequence Detail	7768	Not Applicable
polypeptide	OTTMUSP00000016806	VEGA | MGI Sequence Detail	1757	Not Applicable

All sequences(43) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(530 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003769	Adaptor protein ClpS, core
InterPro	IPR014719	Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
InterPro	IPR003126	Zinc finger, N-recognin
InterPro	IPR013993	Zinc finger, N-recognin, metazoa
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
Protein Ontology	PR:000017012	E3 ubiquitin-protein ligase UBR1

References

(Earliest) J:48738 Kwon YT, et al., The mouse and human genes encoding the recognition component of the N-end rule pathway. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7898-903
(Latest) J:187008 Piatkov KI, et al., The N-end rule pathway counteracts cell death by destroying proapoptotic protein fragments. Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):E1839-47
All references(44)

Other accession IDs

MGI:2138991