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Ep400
Gene Detail
Symbol

Name
ID
Ep400
E1A binding protein p400
MGI:1276124
Synonyms
1700020J09Rik, mDomino, mKIAA1498, p400
Feature Type
protein coding gene
Genetic Map
Chromosome 5
53.69 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:110664373-110770717 bp, - strand
From VEGA annotation of GRCm38

  106345 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EP400
Gene Tree: Ep400

Human
homologs
EP400, E1A binding protein p400
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 57634
neXtProt AC: NX_Q96L91

Human Synonyms: CAGH32, P400, TNRC12

Human Chr (Location): 12q24.33; chr12:131949920-132080466 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(23) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele die at E11.5 and display severe defects in yolk sac erythropoiesis, anemia, and a slight deformity of the neural tube.
 
Phenotype Images(1)
Interactions
Ep400 interacts with 273 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process chromatin modification, histone H2A acetylation, ...
Component NuA4 histone acetyltransferase complex, nuclear speck, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(212)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC779577    NEW 
Molecular
reagents
All nucleic(212) cDNA(212)
Microarray probesets(11)
Other database
links
VEGA Gene Model OTTMUSG00000017135 (Evidence)
Ensembl Gene Model ENSMUSG00000029505 (Evidence)
Entrez Gene 75560 (Evidence)
UniGene 270487
DFCI TC1572649, TC1584429, TC1591395, TC1591868, TC1594897, TC1617393, TC1675546, TC1683116, TC1702606
DoTS DT.101387999, DT.101388000, DT.103569434, DT.110676780, DT.40140571, DT.40140683, DT.91589544, DT.94124925, DT.97408492
NIA Mouse Gene Index U088501
EC 3.6.4.-
Consensus CDS Project CCDS19529.1, CCDS51612.1
International Mouse Phenotyping Consortium Status Ep400
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017135 VEGA Gene Model | MGI Sequence Detail 106345 C57BL/6J ±  kb
transcript OTTMUST00000041482 VEGA | MGI Sequence Detail 10608 Not Applicable 
polypeptide OTTMUSP00000018627 VEGA | MGI Sequence Detail 3035 Not Applicable 

For the selected sequences
All sequences(132) RefSeq(36) UniProt(6)
Polymorphisms
SNPs within 2kb(316 from dbSNP Build 137)    SNPs within 2kb including multiple locations(322)
Protein-related
information
ResourceIDDescription
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014012 Helicase/SANT-associated domain
InterPro IPR014001 Helicase superfamily 1/2, ATP-binding domain
InterPro IPR017877 Myb-like domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001005 SANT/Myb domain
InterPro IPR000330 SNF2-related, N-terminal domain
Protein Ontology PR:000007103 E1A-binding protein p400
References
(Earliest) J:156082 Lill NL, et al., Binding and modulation of p53 by p300/CBP coactivators. Nature. 1997 Jun 19;387(6635):823-7
(Latest) J:207921 Chen PB, et al., Hdac6 regulates Tip60-p400 function in stem cells. Elife. 2013;2:e01557
All references(43)
Other
accession IDs
MGI:1922810, MGI:2141071

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory