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Ep400 Gene Detail
Summary
  • Symbol
    Ep400
  • Name
    E1A binding protein p400
  • Synonyms
    1700020J09Rik, mDomino, mKIAA1498, p400
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276124
    NCBI Gene: 75560
  • Gene Overview
    MyGene.info: EP400
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:110664373-110770717 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.69 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    312 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276124
protein coding gene Chr5:110664373-110770886 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029891
protein coding gene Chr5:113139031-113249074 (-)
A/J MGP_AJ_G0029857
protein coding gene Chr5:108754139-108861425 (-)
AKR/J MGP_AKRJ_G0029795
protein coding gene Chr5:112203176-112310623 (-)
BALB/cJ MGP_BALBcJ_G0029868
protein coding gene Chr5:110123265-110232559 (-)
C3H/HeJ MGP_C3HHeJ_G0029588
protein coding gene Chr5:112637459-112749125 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030321
protein coding gene Chr5:117587040-117700302 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027550
protein coding gene Chr5:103589740-103696181 (-)
CAST/EiJ MGP_CASTEiJ_G0028996
protein coding gene Chr5:111516282-111622554 (-)
CBA/J MGP_CBAJ_G0029555
protein coding gene Chr5:122013488-122122687 (-)
DBA/2J MGP_DBA2J_G0029705
protein coding gene Chr5:108829932-108937152 (-)
FVB/NJ MGP_FVBNJ_G0029662
protein coding gene Chr5:107497267-107609301 (-)
LP/J MGP_LPJ_G0029793
protein coding gene Chr5:113694772-113803881 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029693
protein coding gene Chr5:126657143-126772067 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030362
protein coding gene Chr5:111645793-111760275 (-)
PWK/PhJ MGP_PWKPhJ_G0028710
protein coding gene Chr5:107409593-107517706 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028548
protein coding gene Chr5:109118404-109226162 (-)
WSB/EiJ MGP_WSBEiJ_G0029072
protein coding gene Chr5:112122197-112234462 (-)



Homology
more
  • Human Ortholog
    EP400, E1A binding protein p400
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EP400, E1A binding protein p400
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAGH32, P400, TNRC12
  • Links
    NCBI Gene ID: 57634
    neXtProt AC: NX_Q96L91
    UniProt: Q96L91

  • Chr Location
    12q24.33; chr12:131949920-132080466 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die at E11.5 and display severe defects in yolk sac erythropoiesis, anemia, and a slight deformity of the neural tube.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029505 Ensembl Gene Model | MGI Sequence Detail 106345 C57BL/6J ±  kb
transcript ENSMUST00000041558 Ensembl | MGI Sequence Detail 10608 Not Applicable  
polypeptide ENSMUSP00000049038 Ensembl | MGI Sequence Detail 3035 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 213
    cDNA 213

    Microarray probesets 11
Other
Accession IDs
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MGI:1922810, MGI:2141071
References
more
  • Summaries
    All 46
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:207921 Chen PB, et al., Hdac6 regulates Tip60-p400 function in stem cells. Elife. 2013;2:e01557

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory