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Ep400 Gene Detail
Summary
  • Symbol
    Ep400
  • Name
    E1A binding protein p400
  • Synonyms
    1700020J09Rik, mDomino, mKIAA1498, p400
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276124
    NCBI Gene: 75560
  • Gene Overview
    MyGene.info: EP400
Location & Maps
more
  • Sequence Map
    Chr5:110664373-110770717 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106345 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 53.69 cM, cytoband F
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EP400, E1A binding protein p400
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EP400, E1A binding protein p400
    Orthology source: HomoloGene
  • Synonyms
    CAGH32, P400, TNRC12
  • Links
    NCBI Gene ID: 57634
    neXtProt AC: NX_Q96L91

  • Chr Location
    12q24.33; chr12:131949920-132080466 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    1
  • Gene trapped
    23
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Ep400
  • Incidental Mutations
Mice homozygous for a knock-out allele die at E11.5 and display severe defects in yolk sac erythropoiesis, anemia, and a slight deformity of the neural tube.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017135 VEGA Gene Model | MGI Sequence Detail 106345 C57BL/6J ±  kb
transcript OTTMUST00000041482 VEGA | MGI Sequence Detail 10608 Not Applicable  
polypeptide OTTMUSP00000018627 VEGA | MGI Sequence Detail 3035 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    312 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 212
    cDNA 212

    Microarray probesets 11
Other
Accession IDs
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MGI:1922810, MGI:2141071
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:156082 Lill NL, et al., Binding and modulation of p53 by p300/CBP coactivators. Nature. 1997 Jun 19;387(6635):823-7
  • Latest
    J:207921 Chen PB, et al., Hdac6 regulates Tip60-p400 function in stem cells. Elife. 2013;2:e01557

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory