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Ep400
Gene Detail
Symbol

Name
ID
Ep400
E1A binding protein p400
MGI:1276124
Synonyms
1700020J09Rik, mDomino, mKIAA1498, p400
Feature Type
protein coding gene
Genetic Map
Chromosome 5
53.69 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:110664373-110770717 bp, - strand
From VEGA annotation of GRCm38

  106345 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38779  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ep400

Human
homologs
Human Homolog EP400, E1A binding protein p400
NCBI Gene ID 57634
neXtProt AC  NX_Q96L91
Human Synonyms  CAGH32, P400, TNRC12
Human Chr (Location)  12q24.33; chr12:131949920-132080466 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(23) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele die at E11.5 and display severe defects in yolk sac erythropoiesis, anemia, and a slight deformity of the neural tube.
 
Phenotype Images(1)
Interactions
Ep400 interacts with 274 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process chromatin modification, histone H2A acetylation, ...
Component NuA4 histone acetyltransferase complex, nuclear speck, ...
Function ATP binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(212)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(212) cDNA(212)
Microarray probesets(11)
Other database
links
VEGA Gene ModelOTTMUSG00000017135 (Evidence)
Ensembl Gene ModelENSMUSG00000029505 (Evidence)
Entrez Gene75560 (Evidence)
UniGene270487
DFCITC1591868, TC1591395, TC1584429, TC1572649, TC1594897, TC1617393, TC1702606, TC1683116, TC1675546
DoTSDT.110676780, DT.101388000, DT.103569434, DT.101387999, DT.94124925, DT.40140683, DT.91589544, DT.40140571, DT.97408492
NIA Mouse Gene IndexU088501
EC3.6.4.-
Consensus CDS ProjectCCDS19529.1, CCDS51612.1
International Mouse Knockout Project StatusEp400
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017135 VEGA Gene Model | MGI Sequence Detail 106345 C57BL/6J ±  kb
transcript OTTMUST00000041482 VEGA | MGI Sequence Detail 10608 Not Applicable 
polypeptide OTTMUSP00000018627 VEGA | MGI Sequence Detail 3035 Not Applicable 

For the selected sequences
All sequences(131) RefSeq(30) UniProt(11)
Polymorphisms
SNPs within 2kb(316 from dbSNP Build 137)    SNPs within 2kb including multiple locations(322)
Protein-related
information
ResourceIDDescription
InterPro IPR013999 HAS subgroup
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014012 Helicase/SANT-associated, DNA binding
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR017877 Myb-like domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001005 SANT/Myb domain
InterPro IPR000330 SNF2-related
Protein Ontology PR:000007103 E1A-binding protein p400
References
(Earliest) J:156082 Lill NL, et al., Binding and modulation of p53 by p300/CBP coactivators. Nature. 1997 Jun 19;387(6635):823-7
(Latest) J:207921 Chen PB, et al., Hdac6 regulates Tip60-p400 function in stem cells. Elife. 2013;2:e01557
All references(44)
Other
accession IDs
MGI:1922810, MGI:2141071

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory