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Prep
Gene Detail
Symbol

Name
ID
Prep
prolyl endopeptidase
MGI:1270863
Synonyms
D10Wsu136e, Pop, prolyl oligopeptidase
Feature Type
protein coding gene
Genetic Map
Chromosome 10
23.27 cM, cytoband B2-B3
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:45067206-45158997 bp, + strand
From Ensembl annotation of GRCm38

  91792 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: prolyl oligopeptidase
Gene Tree: Prep

Human
homologs
Human Homolog   PREP, prolyl endopeptidase
NCBI Gene ID 5550
neXtProt AC  NX_P48147
Human Synonyms  PE, PEP
Human Chr (Location)  6q22; chr6:105277567-105403124 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap allele exhibit sex-dependent resistance to diet-induced obesity and adiposity. Mice heterozygous for a gene trap allele exhibit maternal inheritance influenced increase in body weight, organ weight, and adiposity.
 
Interactions
Prep interacts with 85 markers (Mir24-1, Mir24-2, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process protein metabolic process, proteolysis
Component cytoplasm, cytosol, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (60)    Tissues (11)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 54
RT-PCR 6
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000019849 (Evidence)
Entrez Gene19072 (Evidence)
DFCITC1574524, TC1630642, TC1624129, TC1758381, TC1688665, TC1647786
EC3.4.21.26
Consensus CDS ProjectCCDS23826.1
International Mouse Knockout Project StatusPrep
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019849 Ensembl Gene Model | MGI Sequence Detail 91792 C57BL/6J ±  kb
transcript ENSMUST00000099858 Ensembl | MGI Sequence Detail 2729 Not Applicable 
polypeptide ENSMUSP00000097444 Ensembl | MGI Sequence Detail 710 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(534 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023302 Peptidase S9A, oligopeptidase, N-terminal
InterPro IPR002470 Peptidase S9A, prolyl oligopeptidase
InterPro IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
InterPro IPR002471 Peptidase S9, serine active site
Protein Ontology PR:000013200 prolyl endopeptidase
References
(Earliest) J:46890 Ishino T, et al., cDNA cloning of mouse prolyl endopeptidase and its involvement in DNA synthesis by Swiss 3T3 cells. J Biochem. 1998 Mar;123(3):540-5
(Latest) J:213477 D'Agostino G, et al., Prolyl endopeptidase-deficient mice have reduced synaptic spine density in the CA1 region of the hippocampus, impaired LTP, and spatial learning and memory. Cereb Cortex. 2013 Aug;23(8):2007-14
All references(45)
Other
accession IDs
MGD-MRK-35736, MGI:107271, MGI:2143520, MGI:2143608

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory