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Cry1
Gene Detail
Symbol

Name
ID
Cry1
cryptochrome 1 (photolyase-like)
MGI:1270841
Synonyms
Phll1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
41.63 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:85131702-85185054 bp, - strand
From Ensembl annotation of GRCm38

  53353 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CRY1
Protein SuperFamily: deoxyribodipyrimidine photo-lyase
Gene Tree: Cry1

Human
homologs
CRY1, cryptochrome circadian clock 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1407
neXtProt AC: NX_Q16526

Human Synonyms: PHLL1

Human Chr (Location): 12q23-q24.1; chr12:106991364-107093857 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit a one-hour shorter circadian period under constant darkness and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure.
 
Phenotype Images(1)
Interactions
Cry1 interacts with 159 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (66 annotations)
Process circadian regulation of gene expression, circadian rhythm, ...
Component cytoplasm, mitochondrion, ...
Function core promoter binding, core promoter sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (8)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 8
cDNA source data(64)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cry1 ; ZFIN cry1aa, cry1ab    NEW 
Molecular
reagents
All nucleic(69) Genomic(2) cDNA(65) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000020038 (Evidence)
Entrez Gene 12952 (Evidence)
UniGene 26237
DFCI TC1577572
DoTS DT.492493, DT.97372117
NIA Mouse Gene Index U141125
PDB 4CT0, 4K0R
Consensus CDS Project CCDS24089.1
International Mouse Phenotyping Consortium Status Cry1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020038 Ensembl Gene Model | MGI Sequence Detail 53353 C57BL/6J ±  kb
transcript ENSMUST00000020227 Ensembl | MGI Sequence Detail 3014 Not Applicable 
polypeptide ENSMUSP00000020227 Ensembl | MGI Sequence Detail 606 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(260 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005101 Cryptochrome/photolyase FAD-binding domain
InterPro IPR006050 DNA photolyase, N-terminal
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Protein Ontology PR:000005905 cryptochrome-1
References
(Earliest) J:36023 van der Spek PJ, et al., Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors. Genomics. 1996 Oct 15;37(2):177-82
(Latest) J:219981 Gaddameedhi S, et al., The circadian clock controls sunburn apoptosis and erythema in mouse skin. J Invest Dermatol. 2015 Apr;135(4):1119-27
All references(168)
Other
accession IDs
MGD-MRK-37072, MGI:108036, MGI:2143739, MGI:2143771

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory