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Cry1
Gene Detail
 Symbol
Name
ID
Cry1
cryptochrome 1 (photolyase-like)
MGI:1270841
Synonyms Phll1
Feature Type protein coding gene
Genetic Map
Chromosome 10
41.63 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:85131702-85185054 bp, - strand
From Ensembl annotation of GRCm38

  53353 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7042  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: deoxyribodipyrimidine photo-lyase
Gene Tree: Cry1

Human
homologs
Human Homolog CRY1, cryptochrome circadian clock 1
NCBI Gene ID 1407
neXtProt AC  NX_Q16526
Human Synonyms  PHLL1
Human Chr (Location)  12q23-q24.1; chr12:106991364-107093857 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit a one-hour shorter circadian period under constant darkness and reduced expression of another circadian gene in the suprachiasmatic nucleus in response to acute light exposure.
 
Phenotype Images(1)
Interactions
Cry1 interacts with 159 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process circadian regulation of gene expression, circadian rhythm, ...
Component cytoplasm, mitochondrion, ...
Function core promoter binding, core promoter sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (8)    Tissues (6)   
Theiler Stages: 1, 2, 3, 5
Assay TypeResults
RT-PCR 8
cDNA source data(64)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(69) Genomic(2) cDNA(65) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000020038 (Evidence)
Entrez Gene12952 (Evidence)
UniGene26237
DFCITC1577572
DoTSDT.492493, DT.97372117
NIA Mouse Gene IndexU141125
PDB4K0R
Consensus CDS ProjectCCDS24089.1
International Mouse Knockout Project StatusCry1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020038 Ensembl Gene Model | MGI Sequence Detail 53353 C57BL/6J ±  kb
transcript ENSMUST00000020227 Ensembl | MGI Sequence Detail 3014 Not Applicable 
polypeptide ENSMUSP00000020227 Ensembl | MGI Sequence Detail 606 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(260 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005101 DNA photolyase, FAD-binding/Cryptochrome, C-terminal
InterPro IPR006050 DNA photolyase, N-terminal
InterPro IPR014729 Rossmann-like alpha/beta/alpha sandwich fold
Protein Ontology PR:000005905 cryptochrome-1
References (Earliest) J:36023 van der Spek PJ, et al., Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors. Genomics. 1996 Oct 15;37(2):177-82
(Latest) J:210023 Duong HA, et al., Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat Struct Mol Biol. 2014 Feb;21(2):126-32
All references(161)
Other
accession IDs
MGD-MRK-37072, MGI:108036, MGI:2143739, MGI:2143771

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory