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Hdac2
Gene Detail
Symbol

Name
ID
Hdac2
histone deacetylase 2
MGI:1097691
Synonyms
D10Wsu179e, Yy1bp
Feature Type
protein coding gene
Genetic Map
Chromosome 10
19.44 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:36974544-37001889 bp, + strand
From VEGA annotation of GRCm38

  27346 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68187  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: histone deacetylase class I, eukaryotic type
Gene Tree: Hdac2

Human
homologs
Human Homolog HDAC2, histone deacetylase 2
NCBI Gene ID 3066
neXtProt AC  NX_Q92769
Human Synonyms  HD2, RPD3, YAF1
Human Chr (Location)  6q21; chr6:113936156-113971195 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(8) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit embryonic and postnatal lethality accompanied with a transient decrease in body size and increase in heart size and cardiomyocyte proliferation that is overcome by 2 months of age in surviving mice.
 
Interactions
Hdac2 interacts with 256 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (106 annotations)
Process ATP-dependent chromatin remodeling, cardiac muscle cell development, ...
Component chromatin, cytoplasm, ...
Function chromatin binding, chromatin DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (250)    Tissues (139)    Images (74)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 90
RNA in situ 105
Western blot 9
RT-PCR 46
cDNA source data(62)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(73) Genomic(4) cDNA(64) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020840 (Evidence)
Ensembl Gene ModelENSMUSG00000019777 (Evidence)
Entrez Gene15182 (Evidence)
UniGene19806
DFCITC1579905, TC1585639
DoTSDT.40147583, DT.533126
NIA Mouse Gene IndexU011402
EC3.5.1.98
Consensus CDS ProjectCCDS23783.1
International Mouse Knockout Project StatusHdac2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020840 VEGA Gene Model | MGI Sequence Detail 27346 C57BL/6J ±  kb
transcript OTTMUST00000049270 VEGA | MGI Sequence Detail 2005 Not Applicable 
polypeptide OTTMUSP00000022803 VEGA | MGI Sequence Detail 488 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(147 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003084 Histone deacetylase
InterPro IPR023801 Histone deacetylase domain
InterPro IPR000286 Histone deacetylase superfamily
Protein Ontology PR:000008481 histone deacetylase 2
References
(Earliest) J:36570 Yang WM, et al., Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12845-50
(Latest) J:212173 Jamaladdin S, et al., Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9840-5
All references(141)
Other
accession IDs
MGD-MRK-36452, MGI:107875

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory