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Vamp7
Gene Detail
Symbol

Name
ID
Vamp7
vesicle-associated membrane protein 7
MGI:1096399
Synonyms
Sybl1, VAMP-7
Feature Type
protein coding gene
Genetic Map
Chromosome X
Syntenic

Mapping data(3)
Vertebrate
homology
HomoloGene:4121  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Human
homologs
Human Homolog VAMP7, vesicle-associated membrane protein 7
NCBI Gene ID 6845
neXtProt AC  NX_P51809
Human Synonyms  SYBL1, TIVAMP, TI-VAMP, VAMP-7
Human Chr (Location)  XYq28 and Yq12
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
 
Mice homozygous for a null mutation display an increased anxiety related response, increased circulating glycerol level, decreased body temperature, and decreased brain weight.
 
Interactions
Vamp7 interacts with 25 markers (Mir15a, Mir30c-1, Mir30c-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process calcium ion-dependent exocytosis, endocytosis, ...
Component apical part of cell, cell, ...
Function SNAP receptor activity, SNARE binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (19)    Tissues (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
Western blot 7
cDNA source data(62)
External Resources: Allen Institute   GEO  
Molecular
reagents
All nucleic(64) Genomic(1) cDNA(62) Primer pair(1)
Microarray probesets(4)
Other database
links
Entrez Gene20955 (Evidence)
UniGene1517
DFCITC1575730
DoTSDT.487072, DT.101260790
NIA Mouse Gene IndexU041303
PDB4B93, 4AFI, 2VX8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
transcript NM_011515 RefSeq | MGI Sequence Detail 2595 C57BL/6 
polypeptide P70280 UniProt | EBI | MGI Sequence Detail 220 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(6) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(0 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010908 Longin domain
InterPro IPR011012 Longin-like domain
InterPro IPR001388 Synaptobrevin
Protein Ontology PR:000017253 vesicle-associated membrane protein 7
Graphical View of Protein Domain Structure
References
(Earliest) J:43563 D'Esposito M, et al., Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. Hum Mol Genet. 1997 Oct;6(11):1917-23
(Latest) J:206800 Pirooz SD, et al., UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2716-21
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory