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Vamp7 Gene Detail
Summary
  • Symbol
    Vamp7
  • Name
    vesicle-associated membrane protein 7
  • Synonyms
    Sybl1, VAMP-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096399
    NCBI Gene: 20955
  • Gene Overview
    MyGene.info: VAMP7
  • Alliance
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available
  • This gene is annotated to Unlocalized Scaffold from chromosome X, MMCHRX_RANDOM_CTG2 (GL456233.1, NT_165789.2) of Assembly GRCm38.p5. UCSC coordinates are chrX_GL456233_random:10737-39191 bp, - strand.
  • Genetic Map
    Chromosome X, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • Strain Annotations
    1
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096399
protein coding gene Chr2:174046001-174046740 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    VAMP7, vesicle associated membrane protein 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VAMP7, vesicle associated membrane protein 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SYBL1, TIVAMP, TI-VAMP, VAMP-7
  • Links
    NCBI Gene ID: 6845
    neXtProt AC: NX_P51809
    UniProt: P51809

  • Chr Location
    XYq28 and Yq12

  • HomoloGene
    Vertebrate Homology Class 4121
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: VAMP7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display an increased anxiety related response, increased circulating glycerol level, decreased body temperature, and decreased brain weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    • UniGene
    Representative SequencesLengthStrain/SpeciesFlank
    genomic GL456233 GenBank | EMBL | DDBJ | MGI Sequence Detail 336933 C57BL/6J ±  kb
    transcript NM_011515 RefSeq | MGI Sequence Detail 2595 C57BL/6  
    polypeptide P70280 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 1
      cDNA 63
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 8
      Gene Ontology 26
      Phenotypes 7
    • Earliest
      J:43563 D'Esposito M, et al., Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. Hum Mol Genet. 1997 Oct;6(11):1917-23
    • Latest
      J:249354 Aoyagi K, et al., VAMP7 Regulates Autophagy to Maintain Mitochondrial Homeostasis and to Control Insulin Secretion in Pancreatic beta-Cells. Diabetes. 2016 Jun;65(6):1648-59

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory