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Vamp7 Gene Detail
Summary
  • Symbol
    Vamp7
  • Name
    vesicle-associated membrane protein 7
  • Synonyms
    Sybl1, VAMP-7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096399
    NCBI Gene: 20955
  • Gene Overview
    MyGene.info: VAMP7
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome X, Syntenic
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    VAMP7, vesicle associated membrane protein 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    VAMP7, vesicle associated membrane protein 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SYBL1, TIVAMP, TI-VAMP, VAMP-7
  • Links
    NCBI Gene ID: 6845
    neXtProt AC: NX_P51809

  • Chr Location
    XYq28 and Yq12

  • HomoloGene
    Vertebrate Homology Class 4121
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: VAMP7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
Mice homozygous for a null mutation display an increased anxiety related response, increased circulating glycerol level, decreased body temperature, and decreased brain weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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  • All Sequences
  • RefSeq
  • UniProt
  • UniGene
Representative SequencesLengthStrain/SpeciesFlank
transcript NM_011515 RefSeq | MGI Sequence Detail 2595 C57BL/6  
polypeptide P70280 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
For the selected sequence
Polymorphisms
less
  • PCR
Protein
Information
less
Molecular
Reagents
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  • All nucleic 64
    Genomic 1
    cDNA 62
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 54
    Developmental Gene Expression 8
    Gene Ontology 23
    Phenotypes 5
  • Earliest
    J:43563 D'Esposito M, et al., Differential expression pattern of XqPAR-linked genes SYBL1 and IL9R correlates with the structure and evolution of the region. Hum Mol Genet. 1997 Oct;6(11):1917-23
  • Latest
    J:234824 Chiaruttini G, et al., The SNARE VAMP7 Regulates Exocytic Trafficking of Interleukin-12 in Dendritic Cells. Cell Rep. 2016 Mar 22;14(11):2624-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory