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Ung
Gene Detail
Symbol

Name
ID
Ung
uracil DNA glycosylase
MGI:109352
Synonyms
UNG1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
55.97 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:114130386-114139323 bp, + strand
From VEGA annotation of GRCm38

  8938 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6585  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UNG
Gene Tree: Ung

Human
homologs
UNG, uracil DNA glycosylase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7374
neXtProt AC: NX_P13051

Human Synonyms: DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2

Human Chr (Location): 12q23-q24.1; chr12:109097594-109110993 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human UNG

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants incorporate an elevated level of uracil into DNA of dividing cells. In hypermutation at immunoglobulin genes, mutations at C/G pairs are shifted toward transitions, and class-switch recombination is reduced. Homozygous null mutants display increased ischemic brain injury.
 
Interactions
Ung interacts with 118 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process base-excision repair, cellular response to DNA damage stimulus, ...
Component mitochondrion, nucleus
Function hydrolase activity, hydrolase activity, acting on glycosyl bonds, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (217)    Tissues (34)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 193
Northern blot 24
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ung ; ZFIN unga    NEW 
Molecular
reagents
All nucleic(16) Genomic(4) cDNA(12)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000013709 (Evidence)
Ensembl Gene Model ENSMUSG00000029591 (Evidence)
Entrez Gene 22256 (Evidence)
DFCI TC1578798, TC1587676, TC1589458, TC1591987, TC1630321
DoTS DT.101372391, DT.60118327, DT.91332551, DT.91341124
NIA Mouse Gene Index U006024
EC 3.2.2.3, 3.2.2.27
Consensus CDS Project CCDS19560.1, CCDS39221.1
International Mouse Phenotyping Consortium Status Ung
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013709 VEGA Gene Model | MGI Sequence Detail 8938 C57BL/6J ±  kb
transcript OTTMUST00000032859 VEGA | MGI Sequence Detail 1985 Not Applicable 
polypeptide OTTMUSP00000014673 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(140 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002043 Uracil-DNA glycosylase
InterPro IPR018085 Uracil-DNA glycosylase, active site
InterPro IPR005122 Uracil-DNA glycosylase-like
Protein Ontology PR:000017104 uracil-DNA glycosylase
References
(Earliest) J:38558 Nilsen H, et al., Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene. Nucleic Acids Res. 1997 Feb 15;25(4):750-5
(Latest) J:218675 Maul RW, et al., Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells. J Exp Med. 2014 Oct 20;211(11):2297-306
All references(86)
Other
accession IDs
MGD-MRK-38397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory