Ung
Gene Detail

Symbol Name ID

Ung uracil DNA glycosylase MGI:109352

Synonyms

UNG1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

55.97 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:114130386-114139323 bp, + strand From VEGA annotation of GRCm38   8938 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:6585  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ung

Human homologs

Human Homolog		UNG, uracil-DNA glycosylase
NCBI Gene ID		7374
neXtProt AC		NX_P13051
Human Synonyms		DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2
Human Chr (Location)		12q23-q24.1; chr12:109535399-109548798 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human UNG

Alleles and phenotypes

All alleles(15) : Targeted(3) Gene trapped(12)
 

Homozygous null mutants incorporate an elevated level of uracil into DNA of dividing cells. In hypermutation at immunoglobulin genes, mutations at C/G pairs are shifted toward transitions, and class-switch recombination is reduced. Homozygous null mutants display increased ischemic brain injury.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	base-excision repair, DNA repair, ...
Component	mitochondrion, nucleus
Function	hydrolase activity, hydrolase activity, acting on glycosyl bonds, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (217)    Tissues (34)    Images (24)
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
RNA in situ	193
Northern blot	24

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(4) cDNA(12)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000013709 (Evidence)
Ensembl Gene Model	ENSMUSG00000029591 (Evidence)
Entrez Gene	22256 (Evidence)
DFCI	TC1578798, TC1587676, TC1589458, TC1591987, TC1630321
DoTS	DT.101372391, DT.60118327, DT.91332551, DT.91341124
NIA Mouse Gene Index	U006024
EC	3.2.2.3, 3.2.2.27
Consensus CDS Project	CCDS19560.1, CCDS39221.1
International Mouse Knockout Project Status	Ung

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013709	VEGA Gene Model | MGI Sequence Detail	8938	C57BL/6J
transcript	OTTMUST00000032859	VEGA | MGI Sequence Detail	1985	Not Applicable
polypeptide	OTTMUSP00000014673	VEGA | MGI Sequence Detail	306	Not Applicable

All sequences(56) RefSeq(4) UniProt(4)

Polymorphisms

SNPs(92 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002043	Uracil-DNA glycosylase
InterPro	IPR018085	Uracil-DNA glycosylase, active site
InterPro	IPR005122	Uracil-DNA glycosylase-like
Protein Ontology	PR:000017104	uracil-DNA glycosylase

References

(Earliest) J:38558 Nilsen H, et al., Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene. Nucleic Acids Res. 1997 Feb 15;25(4):750-5
(Latest) J:188285 Li S, et al., Analysis of Ig gene hypermutation in Ung(-/-)Polh(-/-) mice suggests that UNG and A:T mutagenesis pathway target different U:G lesions. Mol Immunol. 2013 Mar;53(3):214-7
All references(75)

Other accession IDs

MGD-MRK-38397