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Ung
Gene Detail
Symbol

Name
ID
Ung
uracil DNA glycosylase
MGI:109352
Synonyms
UNG1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
55.97 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:114130386-114139323 bp, + strand
From VEGA annotation of GRCm38

  8938 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6585  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ung

Human
homologs
Human Homolog UNG, uracil-DNA glycosylase
NCBI Gene ID 7374
neXtProt AC  NX_P13051
Human Synonyms  DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2
Human Chr (Location)  12q23-q24.1; chr12:109097594-109110993 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human UNG
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants incorporate an elevated level of uracil into DNA of dividing cells. In hypermutation at immunoglobulin genes, mutations at C/G pairs are shifted toward transitions, and class-switch recombination is reduced. Homozygous null mutants display increased ischemic brain injury.
 
Interactions
Ung interacts with 118 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process base-excision repair, cellular response to DNA damage stimulus, ...
Component mitochondrion, nucleus
Function hydrolase activity, hydrolase activity, acting on glycosyl bonds, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (217)    Tissues (34)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 193
Northern blot 24
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(4) cDNA(12)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000013709 (Evidence)
Ensembl Gene ModelENSMUSG00000029591 (Evidence)
Entrez Gene22256 (Evidence)
DFCITC1591987, TC1589458, TC1587676, TC1578798, TC1630321
DoTSDT.101372391, DT.91332551, DT.60118327, DT.91341124
NIA Mouse Gene IndexU006024
EC3.2.2.3, 3.2.2.27
Consensus CDS ProjectCCDS19560.1, CCDS39221.1
International Mouse Knockout Project StatusUng
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013709 VEGA Gene Model | MGI Sequence Detail 8938 C57BL/6J ±  kb
transcript OTTMUST00000032859 VEGA | MGI Sequence Detail 1985 Not Applicable 
polypeptide OTTMUSP00000014673 VEGA | MGI Sequence Detail 306 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(6) UniProt(7)
Polymorphisms
SNPs within 2kb(140 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002043 Uracil-DNA glycosylase
InterPro IPR018085 Uracil-DNA glycosylase, active site
InterPro IPR005122 Uracil-DNA glycosylase-like
Protein Ontology PR:000017104 uracil-DNA glycosylase
References
(Earliest) J:38558 Nilsen H, et al., Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG gene. Nucleic Acids Res. 1997 Feb 15;25(4):750-5
(Latest) J:212093 Stavnezer J, et al., Differential expression of APE1 and APE2 in germinal centers promotes error-prone repair and A:T mutations during somatic hypermutation. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9217-22
All references(85)
Other
accession IDs
MGD-MRK-38397

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory