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Ung Gene Detail
Summary
  • Symbol
    Ung
  • Name
    uracil DNA glycosylase
  • Synonyms
    UNG1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109352
    NCBI Gene: 22256
  • Gene Overview
    MyGene.info: UNG
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:114130386-114139323 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8938 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 55.97 cM, cytoband F
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    UNG, uracil DNA glycosylase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UNG, uracil DNA glycosylase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DGU, HIGM4, HIGM5, UDG, UNG1, UNG15, UNG2
  • Links
    NCBI Gene ID: 7374
    neXtProt AC: NX_P13051
    UniProt: P13051

  • Chr Location
    12q24.11; chr12:109097594-109110993 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 6585
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UNG
  • Gene Tree
    Ung
Human Diseases
more
  • Diseases
    1 with human UNG associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants incorporate an elevated level of uracil into DNA of dividing cells. In hypermutation at immunoglobulin genes, mutations at C/G pairs are shifted toward transitions, and class-switch recombination is reduced. Homozygous null mutants display increased ischemic brain injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000013709 VEGA Gene Model | MGI Sequence Detail 8938 C57BL/6J ±  kb
    transcript OTTMUST00000032859 VEGA | MGI Sequence Detail 1985 Not Applicable  
    polypeptide OTTMUSP00000014673 VEGA | MGI Sequence Detail 306 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      140 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 4
      cDNA 13
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38397
    References
    more
    • Summaries
      All 101
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 60
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:260744 Methot SP, et al., A licensing step links AID to transcription elongation for mutagenesis in B cells. Nat Commun. 2018 Mar 28;9(1):1248

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory