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Nnt
Gene Detail
Symbol

Name
ID
Nnt
nicotinamide nucleotide transhydrogenase
MGI:109279
Synonyms
4930423F13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 13
67.21 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr13:119335448-119408997 bp, - strand
From VEGA annotation of GRCm38

  73550 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HCOP human homology predictions: NNT
Protein SuperFamily: NAD(P) transhydrogenase (B-specific)
Gene Tree: Nnt
Human
homologs
NNT, nicotinamide nucleotide transhydrogenase
Orthology source: HGNC

IDs:
NCBI Gene ID: 23530
neXtProt AC: NX_Q13423

Human Synonyms: GCCD4

Human Chr (Location): 5p12; chr5:43602689-43705566 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NNT

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Chemically induced (ENU)(2) Gene trapped(21) Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene cause impaired glucose tolerance and loss of both glucose-dependent insulin secretion and ATP production in isolated pancreatic islets. Also, beta cells from ENU-induced mutants show enhanced glucose utilization and production of reactive oxygen species in response to glucose.
 
Interactions
Nnt interacts with 175 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cell redox homeostasis, oxidation-reduction process, ...
Component integral component of membrane, membrane, ...
Function NADP binding, NAD(P)+ transhydrogenase (AB-specific) activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (185)    Tissues (102)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 183
RT-PCR 2
cDNA source data(128)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nnt    NEW 
Molecular
reagents
All nucleic(137) Genomic(2) cDNA(134) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021068 (Evidence)
Ensembl Gene Model ENSMUSG00000025453 (Evidence)
Entrez Gene 18115 (Evidence)
UniGene 132584
DFCI TC1695537, TC1595837, TC1590682, TC1572124, TC1716456
DoTS DT.488948, DT.101738494, DT.101273875, DT.97356629, DT.94358245, DT.91404712, DT.97356660
NIA Mouse Gene Index U035220
EC 1.6.1.2
International Mouse Phenotyping Consortium Status Nnt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021068 VEGA Gene Model | MGI Sequence Detail 73550 C57BL/6J ±  kb
transcript OTTMUST00000049835 VEGA | MGI Sequence Detail 3464 Not Applicable 
polypeptide OTTMUSP00000023153 VEGA | MGI Sequence Detail 835 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(651 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007698 Alanine dehydrogenase/PNT, NAD(H)-binding domain
InterPro IPR008142 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-1
InterPro IPR008143 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2
InterPro IPR007886 Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR026255 NAD(P) transhydrogenase, alpha subunit
InterPro IPR024605 NAD(P) transhydrogenase, alpha subunit, C-terminal
InterPro IPR012136 NADP transhydrogenase, beta subunit
Protein Ontology PR:000011298 NAD(P) transhydrogenase, mitochondrial
References
(Earliest) J:32221 Arkblad EL, et al., The cDNA sequence of proton-pumping nicotinamide nucleotide transhydrogenase from man and mouse. Biochim Biophys Acta. 1996 Mar 28;1273(3):203-5
(Latest) J:205166 Ronchi JA, et al., A spontaneous mutation in the nicotinamide nucleotide transhydrogenase gene of C57BL/6J mice results in mitochondrial redox abnormalities. Free Radic Biol Med. 2013 Oct;63:446-56
All references(55)
Other
accession IDs
MGD-MRK-38324, MGI:1925375, MGI:2145209, MGI:2145477

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory