Nnt
Gene Detail

Symbol Name ID

Nnt nicotinamide nucleotide transhydrogenase MGI:109279

Synonyms

4930423F13Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 13

67.21 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr13:119335448-119408997 bp, - strand From VEGA annotation of GRCm38   73550 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

Protein SuperFamily: NAD(P) transhydrogenase (B-specific)
Gene Tree: Nnt

Alleles and phenotypes

All alleles(26) : Targeted(2) Gene trapped(21) Spontaneous(1) Chemically induced(2)
 

Mutations in this gene cause impaired glucose tolerance and loss of both glucose-dependent insulin secretion and ATP production in isolated pancreatic islets. Also, beta cells from ENU-induced mutants show enhanced glucose utilization and production of reactive oxygen species in response to glucose.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	oxidation-reduction process, proton transport
Component	integral to membrane, membrane, ...
Function	NAD(P)+ transhydrogenase (AB-specific) activity, oxidoreductase activity

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (185)    Tissues (102)    Images (31)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	183
RT-PCR	2

cDNA source data(127)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(136) Genomic(2) cDNA(133) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021068 (Evidence)
Ensembl Gene Model	ENSMUSG00000025453 (Evidence)
Entrez Gene	18115 (Evidence)
UniGene	195803
DFCI	TC1572124, TC1590682, TC1595837, TC1695537, TC1716456
DoTS	DT.101273875, DT.101738494, DT.488948, DT.91404712, DT.94358245, DT.97356629, DT.97356660
NIA Mouse Gene Index	U035220
EC	1.6.1.2
International Mouse Knockout Project Status	Nnt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021068	VEGA Gene Model | MGI Sequence Detail	73550	C57BL/6J
transcript	OTTMUST00000049835	VEGA | MGI Sequence Detail	3464	Not Applicable
polypeptide	OTTMUSP00000023153	VEGA | MGI Sequence Detail	835	Not Applicable

All sequences(67) RefSeq(3) UniProt(9)

Polymorphisms

SNPs(335 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007698	Alanine dehydrogenase/PNT, NAD(H)-binding domain
InterPro	IPR008142	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-1
InterPro	IPR008143	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2
InterPro	IPR007886	Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal
InterPro	IPR016040	NAD(P)-binding domain
InterPro	IPR026255	NAD(P) transhydrogenase, alpha subunit
InterPro	IPR024605	NAD(P) transhydrogenase, alpha subunit, C-terminal
InterPro	IPR012136	NADP transhydrogenase, beta subunit
Protein Ontology	PR:000011298	NAD(P) transhydrogenase, mitochondrial

References

(Earliest) J:32221 Arkblad EL, et al., The cDNA sequence of proton-pumping nicotinamide nucleotide transhydrogenase from man and mouse. Biochim Biophys Acta. 1996 Mar 28;1273(3):203-5
(Latest) J:187454 Ripoll VM, et al., Nicotinamide nucleotide transhydrogenase (NNT) acts as a novel modulator of macrophage inflammatory responses. FASEB J. 2012 Aug;26(8):3550-62
All references(54)

Other accession IDs

MGD-MRK-38324, MGI:1925375, MGI:2145209, MGI:2145477