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Enah Gene Detail
Summary
  • Symbol
    Enah
  • Name
    enabled homolog (Drosophila)
  • Synonyms
    Mena, Ndpp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108360
    NCBI Gene: 13800
  • Gene Overview
    MyGene.info: ENAH
Location & Maps
more
  • Sequence Map
    Chr1:181896384-182019990 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      123607 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 84.93 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ENAH, enabled homolog (Drosophila)
  • Vertebrate Orthologs
    3
  • Human Ortholog
    ENAH, enabled homolog (Drosophila)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ENA, MENA, NDPP1
  • Links
    NCBI Gene ID: 55740
    neXtProt AC: NX_Q8N8S7

  • Chr Location
    1q42.12; chr1:225486832-225661676 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    21 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    330
  • Chemically induced (other)
    2
  • Gene trapped
    324
  • Targeted
    4
  • Genomic Mutations
    2 involving Enah
  • Incidental Mutations
Mice homozygous for a targeted mutation show defects in major axonal projection pathways in brain, including malformation of the hippocampal commissure and pontocerebellar fibers and frequent agenesis of the corpus callosum due to a failure of axons to project across the midline during development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050713 VEGA Gene Model | MGI Sequence Detail 123607 C57BL/6J ±  kb
transcript OTTMUST00000128549 VEGA | MGI Sequence Detail 2889 Not Applicable  
polypeptide OTTMUSP00000069139 VEGA | MGI Sequence Detail 804 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    785 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 28
    cDNA 21
    Primer pair 5
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-12800, MGD-MRK-37400, MGI:2138266, MGI:2138537, MGI:97291
References
more
  • Summaries
    All 64
    Developmental Gene Expression 18
    Gene Ontology 10
    Phenotypes 18
  • Earliest
    J:3109 Sazuka T, et al., Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein. Biochim Biophys Acta. 1992 Oct 20;1132(3):240-8
  • Latest
    J:226997 Bebee TW, et al., The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Elife. 2015;4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory