About   Help   FAQ
Smo
Gene Detail
 Symbol
Name
ID
Smo
smoothened homolog (Drosophila)
MGI:108075
Synonyms E130215L21Rik
Feature Type protein coding gene
Genetic Map
Chromosome 6
12.36 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr6:29735694-29761365 bp, + strand
From VEGA annotation of GRCm38

  25672 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor smoothened homolog
Gene Tree: Smo

Human
homologs
Human Homolog SMO, smoothened, frizzled class receptor
NCBI Gene ID 6608
neXtProt AC  NX_Q99835
Human Synonyms  FZD11, Gx, SMOH
Human Chr (Location)  7q32.3; chr7:129188872-129213545 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Both an ENU-induced mutation and a null mutation are midgestation lethal. Observed defects include failure of neural tube closure and heart and gut defects. Conditional knockouts in chondrocytes and dental epithelium result in short long bones and dentalepithelium derivative defects, respectively.
 
Interactions
Smo interacts with 205 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (131 annotations)
Process adenohypophysis development, anterior/posterior pattern specification, ...
Component axonal growth cone, caveola, ...
Function drug binding, G-protein coupled receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (172)    Tissues (117)    Images (29)
Theiler Stages: 2, 3, 10, 18, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
RNA in situ 128
Northern blot 6
RT-PCR 38
cDNA source data(116)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(127) Genomic(1) cDNA(119) Primer pair(5) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000013446 (Evidence)
Ensembl Gene ModelENSMUSG00000001761 (Evidence)
Entrez Gene319757 (Evidence)
UniGene29279
DFCITC1576926, TC1587732
DoTSDT.101394450, DT.101736449, DT.55267335, DT.87072474, DT.94249037
NIA Mouse Gene IndexU006619, U089023
Consensus CDS ProjectCCDS19965.1
International Mouse Knockout Project StatusSmo
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013446 VEGA Gene Model | MGI Sequence Detail 25672 C57BL/6J ±  kb
transcript OTTMUST00000032499 VEGA | MGI Sequence Detail 3779 Not Applicable 
polypeptide OTTMUSP00000014435 VEGA | MGI Sequence Detail 793 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(5)
Polymorphisms SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
InterPro IPR026544 Smoothened
Protein Ontology PR:000015288 smoothened
References (Earliest) J:36573 Stone DM, et al., The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog [see comments]. Nature. 1996 Nov 14;384(6605):129-34
(Latest) J:205383 Salti A, et al., Expression of early developmental markers predicts the efficiency of embryonic stem cell differentiation into midbrain dopaminergic neurons. Stem Cells Dev. 2013 Feb 1;22(3):397-411
All references(234)
Other
accession IDs
MGD-MRK-37112, MGI:1276113, MGI:2442674

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory