Smo
Gene Detail

Symbol Name ID

Smo smoothened homolog (Drosophila) MGI:108075

Synonyms

E130215L21Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6

12.36 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr6:29735694-29761365 bp, + strand From VEGA annotation of GRCm38   25672 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor smoothened homolog
Gene Tree: Smo

Human homologs

Human Homolog		SMO, smoothened, frizzled family receptor
NCBI Gene ID		6608
neXtProt AC		NX_Q99835
Human Synonyms		FZD11, Gx, SMOH
Human Chr (Location)		7q32.3; chr7:128828713-128853386 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(6) Chemically induced(1)
 

Both an ENU-induced mutation and a null mutation are midgestation lethal. Observed defects include failure of neural tube closure and heart and gut defects. Conditional knockouts in chondrocytes and dental epithelium result in short long bones and dentalepithelium derivative defects, respectively.

 

Gene Ontology (GO) classifications

All GO classifications: (122 annotations)

Process	adenohypophysis development, axon extension involved in axon guidance, ...
Component	axonal growth cone, caveola, ...
Function	drug binding, G-protein coupled receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (59 records)
Data Summary: Results (113)    Tissues (61)    Images (20)
Theiler Stages: 2, 3, 10, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	71
Northern blot	4
RT-PCR	38

cDNA source data(114)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(124) Genomic(1) cDNA(117) Primer pair(4) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000013446 (Evidence)
Ensembl Gene Model	ENSMUSG00000001761 (Evidence)
Entrez Gene	319757 (Evidence)
UniGene	29279
DFCI	TC1576926, TC1587732
DoTS	DT.101394450, DT.101736449, DT.55267335, DT.87072474, DT.94249037
NIA Mouse Gene Index	U006619, U089023
Consensus CDS Project	CCDS19965.1
International Mouse Knockout Project Status	Smo

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013446	VEGA Gene Model | MGI Sequence Detail	25672	C57BL/6J
transcript	OTTMUST00000032499	VEGA | MGI Sequence Detail	3779	Not Applicable
polypeptide	OTTMUSP00000014435	VEGA | MGI Sequence Detail	793	Not Applicable

All sequences(44) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(32 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020067	Frizzled domain
InterPro	IPR000539	Frizzled protein
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR026544	Smoothened
Protein Ontology	PR:000015288	smoothened

References

(Earliest) J:36573 Stone DM, et al., The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog [see comments]. Nature. 1996 Nov 14;384(6605):129-34
(Latest) J:193395 Mukhopadhyay S, et al., The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling. Cell. 2013 Jan 17;152(1-2):210-23
All references(206)

Other accession IDs

MGD-MRK-37112, MGI:1276113, MGI:2442674