Smo
Gene Detail

Symbol

Name
ID

Smo
smoothened homolog (Drosophila)
MGI:108075

Synonyms

E130215L21Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 6
12.36 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr6:29735694-29761365 bp, + strand From VEGA annotation of GRCm38   25672 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4115  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor smoothened homolog
Gene Tree: Smo

Human
homologs

Human Homolog		SMO, smoothened, frizzled class receptor
NCBI Gene ID		6608
neXtProt AC		NX_Q99835
Human Synonyms		FZD11, Gx, SMOH
Human Chr (Location)		7q32.3; chr7:129188872-129213545 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(12) : Chemically induced (ENU)(1) Targeted(9) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 

Both an ENU-induced mutation and a null mutation are midgestation lethal. Observed defects include failure of neural tube closure and heart and gut defects. Conditional knockouts in chondrocytes and dental epithelium result in short long bones and dentalepithelium derivative defects, respectively.

 
Human Diseases Modeled in Mice Using Smo (1)    Mutations Annotated to Human Diseases (3)   

Interactions

Smo interacts with 205 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (113 annotations)

Process	anterior/posterior pattern specification, astrocyte activation, ...
Component	axonal growth cone, caveola, ...
Function	drug binding, G-protein coupled receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (72 records)

Data Summary: Results (172)    Tissues (117)    Images (29)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	128
Northern blot	6
RT-PCR	38

cDNA source data(116)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(127) Genomic(1) cDNA(119) Primer pair(5) Other(2)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000013446 (Evidence)
Ensembl Gene Model	ENSMUSG00000001761 (Evidence)
Entrez Gene	319757 (Evidence)
UniGene	29279
DFCI	TC1587732, TC1576926
DoTS	DT.101736449, DT.101394450, DT.55267335, DT.94249037, DT.87072474
NIA Mouse Gene Index	U089023, U006619
Consensus CDS Project	CCDS19965.1
International Mouse Knockout Project Status	Smo

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013446	VEGA Gene Model | MGI Sequence Detail	25672	C57BL/6J
transcript	OTTMUST00000032499	VEGA | MGI Sequence Detail	3779	Not Applicable
polypeptide	OTTMUSP00000014435	VEGA | MGI Sequence Detail	793	Not Applicable

All sequences(46) RefSeq(4) UniProt(5)

Polymorphisms

SNPs within 2kb(76 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR020067	Frizzled domain
InterPro	IPR000539	Frizzled protein
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR026544	Smoothened
Protein Ontology	PR:000015288	smoothened

References

(Earliest) J:36573 Stone DM, et al., The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog [see comments]. Nature. 1996 Nov 14;384(6605):129-34
(Latest) J:217676 Schwartz AG, et al., Enthesis fibrocartilage cells originate from a population of Hedgehog-responsive cells modulated by the loading environment. Development. 2015 Jan 1;142(1):196-206
All references(242)

Other
accession IDs

MGD-MRK-37112, MGI:1276113, MGI:2442674