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Epyc Gene Detail
Summary
  • Symbol
    Epyc
  • Name
    epiphycan
  • Synonyms
    Dspg3, epiphycan, PG-Lb, SLRR3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:107942
    NCBI Gene: 13516
Location & Maps
more
  • Sequence Map
    Chr10:97644068-97682454 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      38387 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 50.35 cM, cytoband C2-C3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    EPYC, epiphycan
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EPYC, epiphycan
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DSPG3, Pg-Lb, PGLB, SLRR3B
  • Links
    NCBI Gene ID: 1833
    neXtProt AC: NX_Q99645

  • Chr Location
    12q21; chr12:90963679-91007906 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Targeted
    5
  • Genomic Mutations
    1 involving Epyc
  • Incidental Mutations
Mice homozygous for a knock-out exhibit short femurs and borderline osteoarthritis at 9 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024039 VEGA Gene Model | MGI Sequence Detail 38387 C57BL/6J ±  kb
transcript OTTMUST00000058776 VEGA | MGI Sequence Detail 2539 Not Applicable  
polypeptide OTTMUSP00000028520 VEGA | MGI Sequence Detail 322 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    246 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    Genomic 4
    cDNA 37

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36522
References
more
  • Summaries
    All 35
    Developmental Gene Expression 8
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:35562 Kurita K, et al., Occurrence of PG-Lb, a leucine-rich small chondroitin/dermatan sulphate proteoglycan in mammalian epiphyseal cartilage: molecular cloning and sequence analysis of the mouse cDNA. Biochem J. 1996 Sep 15;318(Pt 3):909-14
  • Latest
    J:199664 Huang H, et al., Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem. 2013 Jun 14;288(24):17589-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory