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Tia1
Gene Detail
 Symbol
Name
ID
Tia1
cytotoxic granule-associated RNA binding protein 1
MGI:107914
Synonyms 2310050N03Rik, mTIA-1
Feature Type protein coding gene
Genetic Map
Chromosome 6
37.69 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:86404219-86433403 bp, + strand
From VEGA annotation of GRCm38

  29185 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20692  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Tia1

Human
homologs
Human Homolog TIA1, TIA1 cytotoxic granule-associated RNA binding protein
NCBI Gene ID 7072
neXtProt AC  NX_P31483
Human Synonyms  TIA-1, WDM
Human Chr (Location)  2p13; chr2:70209444-70248744 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TIA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(39) : Gene trapped(34) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit reduced postnatal survival and functional abnormalities in the immune system with no gross abnormalities in any of the major organs.
 
Interactions
Tia1 interacts with 413 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process apoptotic process, negative regulation of cytokine biosynthetic process, ...
Component cytoplasm, cytoplasmic stress granule, ...
Function AU-rich element binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (66)    Tissues (31)    Images (31)
Theiler Stages: 21, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 62
RT-PCR 4
cDNA source data(165)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(176) Genomic(3) cDNA(171) Primer pair(2)
Microarray probesets(9)
Other database
links
VEGA Gene ModelOTTMUSG00000022840 (Evidence)
Ensembl Gene ModelENSMUSG00000071337 (Evidence)
Entrez Gene21841 (Evidence)
UniGene333219
DFCITC1574881, TC1582714, TC1590651, TC1603043, TC1615261, TC1639333
DoTSDT.110488904, DT.40186634, DT.533612, DT.91403693, DT.94342735, DT.97366316, DT.97391821, DT.99868181
NIA Mouse Gene IndexU007118
PDB2DGO, 2RNE
Consensus CDS ProjectCCDS20312.1, CCDS51833.1, CCDS51834.1
International Mouse Knockout Project StatusTia1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022840 VEGA Gene Model | MGI Sequence Detail 29185 C57BL/6J ±  kb
transcript OTTMUST00000054884 VEGA | MGI Sequence Detail 4475 Not Applicable 
polypeptide OTTMUSP00000026222 VEGA | MGI Sequence Detail 386 Not Applicable 

For the selected sequences
All sequences(137) RefSeq(19) UniProt(9)
Polymorphisms SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR000504 RNA recognition motif domain
References (Earliest) J:36106 Beck AR, et al., Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR. Nucleic Acids Res. 1996 Oct 1;24(19):3829-35
(Latest) J:199302 Veenvliet JV, et al., Specification of dopaminergic subsets involves interplay of En1 and Pitx3. Development. 2013 Aug;140(16):3373-84
All references(57)
Other
accession IDs
MGD-MRK-36494, MGI:1889799, MGI:1914358

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory