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Tia1
Gene Detail
Symbol

Name
ID
Tia1
cytotoxic granule-associated RNA binding protein 1
MGI:107914
Synonyms
2310050N03Rik, mTIA-1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
37.69 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:86404219-86433403 bp, + strand
From VEGA annotation of GRCm38

  29185 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20692  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TIA1
Gene Tree: Tia1

Human
homologs
TIA1, TIA1 cytotoxic granule-associated RNA binding protein
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7072
neXtProt AC: NX_P31483

Human Synonyms: TIA-1, WDM

Human Chr (Location): 2p13; chr2:70209444-70248707 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TIA1

Mutations,
alleles, and
phenotypes
All mutations/alleles(40) : Gene trapped(34) Spontaneous(1) Targeted(5)
Genomic Mutations involving Tia1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit reduced postnatal survival and functional abnormalities in the immune system with no gross abnormalities in any of the major organs.
 
Interactions
Tia1 interacts with 412 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process apoptotic process, negative regulation of cytokine biosynthetic process, ...
Component cytoplasm, cytoplasmic stress granule, ...
Function AU-rich element binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (193)    Tissues (130)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 188
Northern blot 1
RT-PCR 4
cDNA source data(166)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tia1 ; ZFIN tia1    NEW 
Molecular
reagents
All nucleic(177) Genomic(3) cDNA(172) Primer pair(2)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000022840 (Evidence)
Ensembl Gene Model ENSMUSG00000071337 (Evidence)
Entrez Gene 21841 (Evidence)
UniGene 333219
DFCI TC1574881, TC1582714, TC1590651, TC1603043, TC1615261, TC1639333
DoTS DT.110488904, DT.40186634, DT.533612, DT.91403693, DT.94342735, DT.97366316, DT.97391821, DT.99868181
NIA Mouse Gene Index U007118
PDB 2DGO, 2RNE
Consensus CDS Project CCDS20312.1, CCDS51833.1, CCDS51834.1
International Mouse Phenotyping Consortium Status Tia1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022840 VEGA Gene Model | MGI Sequence Detail 29185 C57BL/6J ±  kb
transcript OTTMUST00000054884 VEGA | MGI Sequence Detail 4475 Not Applicable 
polypeptide OTTMUSP00000026222 VEGA | MGI Sequence Detail 386 Not Applicable 

For the selected sequences
All sequences(137) RefSeq(19) UniProt(8)
Polymorphisms
SNPs within 2kb(199 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012677 Nucleotide-binding alpha-beta plait domain
InterPro IPR000504 RNA recognition motif domain
References
(Earliest) J:36106 Beck AR, et al., Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR. Nucleic Acids Res. 1996 Oct 1;24(19):3829-35
(Latest) J:207743 Sanchez-Jimenez C, et al., T-cell intracellular antigen (TIA)-proteins deficiency in murine embryonic fibroblasts alters cell cycle progression and induces autophagy. PLoS One. 2013;8(9):e75127
All references(58)
Other
accession IDs
MGD-MRK-36494, MGI:1889799, MGI:1914358

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory