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Tia1 Gene Detail
Summary
  • Symbol
    Tia1
  • Name
    cytotoxic granule-associated RNA binding protein 1
  • Synonyms
    2310050N03Rik, mTIA-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107914
    NCBI Gene: 21841
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:86404219-86433405 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29187 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 37.69 cM, cytoband D2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    TIA1, TIA1 cytotoxic granule associated RNA binding protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TIA1, TIA1 cytotoxic granule associated RNA binding protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TIA-1, WDM
  • Links
    NCBI Gene ID: 7072
    neXtProt AC: NX_P31483
    UniProt: P31483

  • Chr Location
    2p13.3; chr2:70209444-70248793 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 20692
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TIA1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit reduced postnatal survival and functional abnormalities in the immune system with no gross abnormalities in any of the major organs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022840 VEGA Gene Model | MGI Sequence Detail 29187 C57BL/6J ±  kb
    transcript OTTMUST00000054884 VEGA | MGI Sequence Detail 4477 Not Applicable  
    polypeptide OTTMUSP00000026222 VEGA | MGI Sequence Detail 386 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      197 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 177
      Genomic 3
      cDNA 172
      Primer pair 2

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-36494, MGI:1889799, MGI:1914358
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 8
      Gene Ontology 12
      Phenotypes 13
    • Earliest
      J:36106 Beck AR, et al., Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR. Nucleic Acids Res. 1996 Oct 1;24(19):3829-35
    • Latest
      J:252244 Diaz-Munoz MD, et al., Tia1 dependent regulation of mRNA subcellular location and translation controls p53 expression in B cells. Nat Commun. 2017 Sep 13;8(1):530

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory