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Abr Gene Detail
Summary
  • Symbol
    Abr
  • Name
    active BCR-related gene
  • Synonyms
    6330400K15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107771
    NCBI Gene: 109934
Location & Maps
more
  • Sequence Map
    Chr11:76416734-76622314 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      205581 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.92 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ABR, active BCR-related
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ABR, active BCR-related
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MDB
  • Links
    NCBI Gene ID: 29
    neXtProt AC: NX_Q12979

  • Chr Location
    17p13.3; chr17:1003518-1187322 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotypes from multigenic genotypes
    23 phenotype references
  • All Mutations and Alleles
    44
  • Chemically induced (other)
    1
  • Gene trapped
    39
  • Targeted
    4
  • Genomic Mutations
    2 involving Abr
  • Incidental Mutations
Homozygous null mutants are apparently normal, but double knockouts with Bcr show increased postnatal mortality, ataxia, hyperactivity, circling, lack of vestibular otoconia, ectopic cerebellar granule cells, and foliation defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006233 VEGA Gene Model | MGI Sequence Detail 205581 C57BL/6J ±  kb
transcript OTTMUST00000014072 VEGA | MGI Sequence Detail 5236 Not Applicable  
polypeptide OTTMUSP00000006539 VEGA | MGI Sequence Detail 871 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1227 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 257
    cDNA 256
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36348, MGI:2144432
References
more
  • Summaries
    All 45
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 23
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:213862 Um K, et al., Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23;29(6):701-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory