About   Help   FAQ
Abr Gene Detail
Summary
  • Symbol
    Abr
  • Name
    active BCR-related gene
  • Synonyms
    6330400K15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107771
    NCBI Gene: 109934
  • Alliance
    genome feature page
  • Transcription Start Sites
    41 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:76307560-76468515 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4127 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107771
 protein coding gene Chr11:76307560-76514384 (-)
129S1/SvImJ ENSMUSG00200046042
 protein coding gene Chr11:73438339-73636610 (-)
A/J ENSMUSG00195037409
 protein coding gene Chr11:73316808-73515086 (-)
AKR/J ENSMUSG00220046534
 protein coding gene Chr11:73532018-73730302 (-)
BALB/cJ ENSMUSG00180035013
 protein coding gene Chr11:73505256-73703533 (-)
C3H/HeJ ENSMUSG00175033032
 protein coding gene Chr11:73475141-73673409 (-)
C57BL/6NJ ENSMUSG00215039841
 protein coding gene Chr11:73084064-73290913 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016761
 protein coding gene Chr11:71362668-71557745 (-)
CAST/EiJ ENSTCUG00005043311
 protein coding gene Chr11:72996257-73192619 (-)
CBA/J ENSMUSG00210042152
 protein coding gene Chr11:73293588-73491854 (-)
DBA/2J ENSMUSG00185030708
 protein coding gene Chr11:73563587-73761846 (-)
FVB/NJ ENSMUSG00205018869
 protein coding gene Chr11:73400213-73598485 (-)
JF1/MsJ ENSUMUG00000022997
 protein coding gene Chr11:73936072-74132489 (-)
LP/J ENSMUSG00230047402
 protein coding gene Chr11:74594176-74792437 (-)
NOD/ShiLtJ ENSMUSG00190046322
 protein coding gene Chr11:73611465-73809037 (-)
NZO/HlLtJ ENSMUSG00225038534
 protein coding gene Chr11:76753949-76952708 (-)
PWK/PhJ ENSLUMG00010019628
 protein coding gene Chr11:73461614-73658322 (-)
SPRET/EiJ ENSMSPG00010039525
 protein coding gene Chr11:73851307-74047749 (-)
WSB/EiJ ENSIUOG00005031977
 protein coding gene Chr11:73455789-73654614 (-)



Homology
more
  • Human Ortholog
    ABR, ABR activator of RhoGEF and GTPase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABR, ABR activator of RhoGEF and GTPase
  • Synonyms
    MDB
  • Links
    NCBI Gene ID: 29
    UniProt: Q12979

  • Chr Location
    17p13.3; chr17:1003519-1229738 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotypes from multigenic genotypes
    24 phenotype references
Homozygous null mutants are apparently normal, but double knockouts with Bcr show increased postnatal mortality, ataxia, hyperactivity, circling, lack of vestibular otoconia, ectopic cerebellar granule cells, and foliation defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    949
  • Tissues
    89
  • cDNA Data
    257
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 109934 NCBI Gene Model | MGI Sequence Detail 160956 C57BL/6J ±  kb
transcript NM_001436202 RefSeq | MGI Sequence Detail 6265 C57BL/6  
polypeptide Q5SSL4 UniProt | EBI | MGI Sequence Detail 859 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 259
    cDNA 257
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36348, MGI:2144432
References
more
  • Summaries
    All 62
    Developmental Gene Expression 7
    Gene Ontology 13
    Phenotypes 24
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory