Abr
Gene Detail

Symbol Name ID

Abr active BCR-related gene MGI:107771

Synonyms

6330400K15Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:76416734-76622314 bp, - strand From VEGA annotation of GRCm38   205581 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11081  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: chaperone HSP70
Gene Tree: Abr

Human homologs

Human Homolog		ABR, active BCR-related
NCBI Gene ID		29
neXtProt AC		NX_Q12979
Human Synonyms		MDB
Human Chr (Location)		17p13.3; chr17:906758-1090616 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(42) : Targeted(3) Gene trapped(39)
 

Homozygous null mutants are apparently normal, but double knockouts with Bcr show increased postnatal mortality, ataxia, hyperactivity, circling, lack of vestibular otoconia, ectopic cerebellar granule cells, and foliation defects.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	actin cytoskeleton organization, brain development, ...
Component	cytosol, intracellular, ...
Function	GTPase activator activity, guanyl-nucleotide exchange factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (313)    Tissues (55)    Images (34)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	313

cDNA source data(253)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(254) cDNA(253) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006233 (Evidence)
Ensembl Gene Model	ENSMUSG00000017631 (Evidence)
Entrez Gene	109934 (Evidence)
UniGene	258939
DFCI	TC1572207, TC1632144, TC1642802
DoTS	DT.101126862, DT.101230164, DT.101405314, DT.101738783, DT.102557145, DT.110540393, DT.490732, DT.94361004, DT.97408523
NIA Mouse Gene Index	U033100
Consensus CDS Project	CCDS25066.1, CCDS25067.1, CCDS36231.1
International Mouse Knockout Project Status	Abr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006233	VEGA Gene Model | MGI Sequence Detail	205581	C57BL/6J
transcript	OTTMUST00000014072	VEGA | MGI Sequence Detail	5236	Not Applicable
polypeptide	OTTMUSP00000006539	VEGA | MGI Sequence Detail	871	Not Applicable

All sequences(92) RefSeq(6) UniProt(6)

Polymorphisms

SNPs(550 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR000219	Dbl homology (DH) domain
InterPro	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR000198	Rho GTPase-activating protein domain
InterPro	IPR008936	Rho GTPase activation protein
Protein Ontology	PR:000003589	active breakpoint cluster region-related protein

References

(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:195022 Yu M, et al., Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. PLoS One. 2012;7(11):e49756
All references(45)

Other accession IDs

MGD-MRK-36348, MGI:2144432