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Abr
Gene Detail
Symbol

Name
ID
Abr
active BCR-related gene
MGI:107771
Synonyms
6330400K15Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:76416734-76622314 bp, - strand
From VEGA annotation of GRCm38

  205581 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11081  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: chaperone HSP70
Gene Tree: Abr

Human
homologs
Human Homolog ABR, active BCR-related
NCBI Gene ID 29
neXtProt AC  NX_Q12979
Human Synonyms  MDB
Human Chr (Location)  17p13.3; chr17:1003518-1229630 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(42) : Gene trapped(39) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are apparently normal, but double knockouts with Bcr show increased postnatal mortality, ataxia, hyperactivity, circling, lack of vestibular otoconia, ectopic cerebellar granule cells, and foliation defects.
 
Interactions
Abr interacts with 312 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process actin cytoskeleton organization, brain development, ...
Component cytosol, intracellular, ...
Function GTPase activator activity, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (341)    Tissues (83)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 341
cDNA source data(256)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(257) cDNA(256) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006233 (Evidence)
Ensembl Gene ModelENSMUSG00000017631 (Evidence)
Entrez Gene109934 (Evidence)
UniGene258939
DFCITC1666007, TC1572207, TC1642802, TC1632144, TC1610387
DoTSDT.101126862, DT.101230164, DT.101405314, DT.110540393, DT.490732, DT.102557145, DT.101738783, DT.97408523, DT.94361004
NIA Mouse Gene IndexU033100
Consensus CDS ProjectCCDS25066.1, CCDS25067.1, CCDS36231.1, CCDS70246.1
International Mouse Knockout Project StatusAbr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006233 VEGA Gene Model | MGI Sequence Detail 205581 C57BL/6J ±  kb
transcript OTTMUST00000014072 VEGA | MGI Sequence Detail 5236 Not Applicable 
polypeptide OTTMUSP00000006539 VEGA | MGI Sequence Detail 871 Not Applicable 

For the selected sequences
All sequences(112) RefSeq(12) UniProt(13)
Polymorphisms
SNPs within 2kb(1240 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000003589 active breakpoint cluster region-related protein
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:213862 Um K, et al., Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23;29(6):701-15
All references(50)
Other
accession IDs
MGD-MRK-36348, MGI:2144432

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory