Cav3
Gene Detail

Symbol Name ID

Cav3 caveolin 3 MGI:107570

Synonyms

Cav-3, M-caveolin

Feature Type

protein coding gene

Genetic Map

Chromosome 6

52.26 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:112459505-112472872 bp, + strand From NCBI annotation of GRCm38   13368 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7255  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: caveolin-1
Gene Tree: Cav3

Human homologs

Human Homolog		CAV3, caveolin 3
NCBI Gene ID		859
neXtProt AC		NX_P56539
Human Synonyms		LGMD1C, LQT9, VIP21, VIP-21
Human Chr (Location)		3p25; chr3:8775486-8788451 (+)  GRCh37.p10
Disease Associations		(6) Diseases Associated with Human CAV3

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous targeted mutant animals display mild myopathic changes in muscle.

 
Human Diseases Modeled Using Mouse Cav3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (109 annotations)

Process	actin filament organization, cardiac muscle cell development, ...
Component	caveola, cell surface, ...
Function	alpha-tubulin binding, calcium channel regulator activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (82)    Tissues (14)    Images (23)
Theiler Stages: 10, 18, 20, 21, 22, 23, 24, 25

Assay Type	Results
Immunohistochemistry	3
RNA in situ	69
Northern blot	4
Western blot	3
RT-PCR	3

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(1) cDNA(14) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000062694 (Evidence)
Entrez Gene	12391 (Evidence)
UniGene	3924
DFCI	TC1582762
DoTS	DT.529981, DT.55136615
NIA Mouse Gene Index	U007257
Consensus CDS Project	CCDS20406.1
International Mouse Knockout Project Status	Cav3

Sequences

Length	Strain/Species
genomic	12391	NCBI Gene Model | MGI Sequence Detail	13368	C57BL/6J
transcript	NM_007617	RefSeq | MGI Sequence Detail	1172	C57BL/6
polypeptide	P51637	UniProt | EBI | MGI Sequence Detail	151	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(104 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001612	Caveolin
InterPro	IPR018361	Caveolin, conserved site
Protein Ontology	PR:000005065	caveolin-3

Graphical View of Protein Domain Structure

References

(Earliest) J:20873 Tang ZL, et al., The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C. Gene. 1994 Sep 30;147(2):299-300
(Latest) J:195952 Wang Y, et al., Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):934-42
All references(89)

Other accession IDs

MGD-MRK-36142, MGI:2141400