Inpp5d
Gene Detail

Symbol Name ID

Inpp5d inositol polyphosphate-5-phosphatase D MGI:107357

Synonyms

SHIP, SHIP1, SHIP-1, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP

Feature Type

protein coding gene

Genetic Map

Chromosome 1

44.44 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr1:87620312-87720507 bp, + strand From VEGA annotation of GRCm38   100196 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4046  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Inpp5d

Human homologs

Human Homolog		INPP5D, inositol polyphosphate-5-phosphatase, 145kDa
NCBI Gene ID		3635
neXtProt AC		NX_Q92835
Human Synonyms		hp51CN, SHIP, SHIP1, SHIP-1, SIP-145
Human Chr (Location)		2q37.1

Alleles and phenotypes

All alleles(62) : Targeted(7) Gene trapped(53) Chemically induced(2)
 

Homozygous null mice fail to reject fully mismatched allogeneic marrow grafts, do not develop graft versus host disease, and show enhanced survival after such transplants. Homozygous splice site mutants exhibit wasting, granulocytic lung infiltration and defective cytolysis by NK cells and CTLs.

 
Human Diseases Modeled Using Mouse Inpp5d (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	apoptotic process, dephosphorylation, ...
Component	actin filament, cortical cytoskeleton, ...
Function	hydrolase activity, inositol-4,5-bisphosphate 5-phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (123)    Tissues (103)    Images (20)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	116
RT-PCR	4
RNase protection	3

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(55) Genomic(2) cDNA(51) Primer pair(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000035865 (Evidence)
Ensembl Gene Model	ENSMUSG00000026288 (Evidence)
Entrez Gene	16331 (Evidence)
UniGene	15105
DFCI	TC1575786, TC1594794, TC1715337, TC1758107
DoTS	DT.101297366, DT.101362827, DT.101362828, DT.110913688, DT.526932, DT.94197896, DT.94197900, DT.97406813
NIA Mouse Gene Index	U000562
EC	3.1.3.86
Consensus CDS Project	CCDS35655.1, CCDS48310.1, CCDS48311.1
International Mouse Knockout Project Status	Inpp5d

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035865	VEGA Gene Model | MGI Sequence Detail	100196	C57BL/6J
transcript	OTTMUST00000091932	VEGA | MGI Sequence Detail	4937	Not Applicable
polypeptide	OTTMUSP00000050698	VEGA | MGI Sequence Detail	1191	Not Applicable

All sequences(87) RefSeq(6) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(497 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005135	Endonuclease/exonuclease/phosphatase
InterPro	IPR000300	Inositol polyphosphate-related phosphatase
InterPro	IPR000980	SH2 domain
Protein Ontology	PR:000003302	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1

References

(Earliest) J:35425 Chacko GW, et al., Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. J Immunol. 1996 Sep 15;157(6):2234-8
(Latest) J:192824 Leung WH, et al., Aberrant antibody affinity selection in SHIP-deficient B cells. Eur J Immunol. 2013 Feb;43(2):371-81
All references(163)

Other accession IDs

MGD-MRK-35823, MGI:2138207