About   Help   FAQ
Inpp5d Gene Detail
Summary
  • Symbol
    Inpp5d
  • Name
    inositol polyphosphate-5-phosphatase D
  • Synonyms
    SHIP, SHIP1, SHIP-1, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:107357
    NCBI Gene: 16331
  • Gene Overview
    MyGene.info: INPP5D
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:87620312-87720507 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.44 cM, cytoband C5
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    587 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107357
protein coding gene Chr1:87620312-87720510 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016268
protein coding gene Chr1:88989928-89095540 (+)
A/J MGP_AJ_G0016249
protein coding gene Chr1:85651449-85755146 (+)
AKR/J MGP_AKRJ_G0016210
protein coding gene Chr1:88177855-88294420 (+)
BALB/cJ MGP_BALBcJ_G0016206
protein coding gene Chr1:85773211-85874387 (+)
C3H/HeJ MGP_C3HHeJ_G0016034
protein coding gene Chr1:88440251-88547198 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016663
protein coding gene Chr1:92287740-92394361 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014384
protein coding gene Chr1:80101586-80204782 (+)
CAST/EiJ MGP_CASTEiJ_G0015619
protein coding gene Chr1:87655514-87762683 (+)
CBA/J MGP_CBAJ_G0016010
protein coding gene Chr1:95234712-95350750 (+)
DBA/2J MGP_DBA2J_G0016113
protein coding gene Chr1:84949716-85050812 (+)
FVB/NJ MGP_FVBNJ_G0016112
protein coding gene Chr1:84010752-84114624 (+)
LP/J MGP_LPJ_G0016184
protein coding gene Chr1:90034436-90137181 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016138
protein coding gene Chr1:98510750-98620305 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016705
protein coding gene Chr1:88295217-88407241 (+)
PWK/PhJ MGP_PWKPhJ_G0015406
protein coding gene Chr1:84246646-84360769 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015186
protein coding gene Chr1:87199046-87300107 (+)
WSB/EiJ MGP_WSBEiJ_G0015683
protein coding gene Chr1:87962599-88074365 (+)



Homology
more
  • Human Ortholog
    INPP5D, inositol polyphosphate-5-phosphatase D
  • Vertebrate Orthologs
    9
  • Human Ortholog
    INPP5D, inositol polyphosphate-5-phosphatase D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hp51CN, p150Ship, SHIP, SHIP1, SHIP-1, SIP-145
  • Links
    NCBI Gene ID: 3635
    neXtProt AC: NX_Q92835
    UniProt: Q92835

  • Chr Location
    2q37.1; chr2:233059967-233207903 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Inpp5d mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    99 phenotypes from 11 alleles in 15 genetic backgrounds
    22 phenotypes from multigenic genotypes
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice fail to reject fully mismatched allogeneic marrow grafts, do not develop graft versus host disease, and show enhanced survival after such transplants. Homozygous splice site mutants exhibit wasting, granulocytic lung infiltration anddefective cytolysis by NK cells and CTLs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026288 Ensembl Gene Model | MGI Sequence Detail 100196 C57BL/6J ±  kb
    transcript ENSMUST00000169754 Ensembl | MGI Sequence Detail 4937 Not Applicable  
    polypeptide ENSMUSP00000127941 Ensembl | MGI Sequence Detail 1191 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 2
      cDNA 53
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-35823, MGI:2138207
    References
    more
    • Summaries
      All 199
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 15
      Phenotypes 115
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:265321 Tsantikos E, et al., Granulocyte-CSF links destructive inflammation and comorbidities in obstructive lung disease. J Clin Invest. 2018 Jun 1;128(6):2406-2418

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory