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Inpp5d Gene Detail
Summary
  • Symbol
    Inpp5d
  • Name
    inositol polyphosphate-5-phosphatase D
  • Synonyms
    SHIP, SHIP1, SHIP-1, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP
  • Feature Type
    protein coding gene
  • IDs
    MGI:107357
    NCBI Gene: 16331
  • Gene Overview
    MyGene.info: INPP5D
Location & Maps
more
  • Sequence Map
    Chr1:87620312-87720507 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      100196 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 44.44 cM, cytoband C5
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    INPP5D, inositol polyphosphate-5-phosphatase D
  • Vertebrate Orthologs
    9
  • Human Ortholog
    INPP5D, inositol polyphosphate-5-phosphatase D
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hp51CN, p150Ship, SHIP, SHIP1, SHIP-1, SIP-145
  • Links
    NCBI Gene ID: 3635
    neXtProt AC: NX_Q92835

  • Chr Location
    2q37.1; chr2:233059967-233207903 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Inpp5d mouse models

Human Disease Mouse Models
       Paget Disease of Bone 2, Early-Onset; PDB2   OMIM: 602080 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    98 phenotypes from 10 alleles in 14 genetic backgrounds
    22 phenotypes from multigenic genotypes
    106 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    66
  • Chemically induced (ENU)
    4
  • Chemically induced (other)
    1
  • Gene trapped
    53
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Inpp5d
  • Incidental Mutations
Homozygous null mice fail to reject fully mismatched allogeneic marrow grafts, do not develop graft versus host disease, and show enhanced survival after such transplants. Homozygous splice site mutants exhibit wasting, granulocytic lung infiltration anddefective cytolysis by NK cells and CTLs.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035865 VEGA Gene Model | MGI Sequence Detail 100196 C57BL/6J ±  kb
transcript OTTMUST00000091932 VEGA | MGI Sequence Detail 4937 Not Applicable  
polypeptide OTTMUSP00000050698 VEGA | MGI Sequence Detail 1191 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    587 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000003302 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
  • EC
  • InterPro Domains
    IPR005135 Endonuclease/exonuclease/phosphatase
    IPR000300 Inositol polyphosphate-related phosphatase
    IPR000980 SH2 domain
Molecular
Reagents
less
  • All nucleic 56
    Genomic 2
    cDNA 52
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35823, MGI:2138207
References
more
  • Summaries
    All 169
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 13
    Phenotypes 106
  • Earliest
    J:35425 Chacko GW, et al., Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. J Immunol. 1996 Sep 15;157(6):2234-8
  • Latest
    J:224475 Mager LF, et al., IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms. J Clin Invest. 2015 Jul 1;125(7):2579-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory