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Inpp5d
Gene Detail
Symbol

Name
ID
Inpp5d
inositol polyphosphate-5-phosphatase D
MGI:107357
Synonyms
SHIP, SHIP1, SHIP-1, Src homology 2 domain-containing inositol-5-phosphatase, s-SHIP
Feature Type
protein coding gene
Genetic Map
Chromosome 1
44.44 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr1:87620312-87720507 bp, + strand
From VEGA annotation of GRCm38

  100196 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4046  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Inpp5d

Human
homologs
Human Homolog INPP5D, inositol polyphosphate-5-phosphatase, 145kDa
NCBI Gene ID 3635
neXtProt AC  NX_Q92835
Human Synonyms  hp51CN, p150Ship, SHIP, SHIP1, SHIP-1, SIP-145
Human Chr (Location)  2q37.1; chr2:233060326-233207903 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(63) : Chemically induced (ENU)(3) Gene trapped(53) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice fail to reject fully mismatched allogeneic marrow grafts, do not develop graft versus host disease, and show enhanced survival after such transplants. Homozygous splice site mutants exhibit wasting, granulocytic lung infiltration and defective cytolysis by NK cells and CTLs.
 
Human Diseases Modeled Using Mouse Inpp5d (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Inpp5d interacts with 238 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process apoptotic process, dephosphorylation, ...
Component actin filament, cortical cytoskeleton, ...
Function hydrolase activity, inositol-4,5-bisphosphate 5-phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (123)    Tissues (103)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 116
RT-PCR 4
RNase protection 3
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) Genomic(2) cDNA(52) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000035865 (Evidence)
Ensembl Gene ModelENSMUSG00000026288 (Evidence)
Entrez Gene16331 (Evidence)
UniGene15105
DFCITC1575786, TC1594794, TC1715337, TC1758107
DoTSDT.101297366, DT.101362827, DT.101362828, DT.110913688, DT.526932, DT.94197896, DT.94197900, DT.97406813
NIA Mouse Gene IndexU000562
EC3.1.3.86
Consensus CDS ProjectCCDS35655.1, CCDS48310.1, CCDS48311.1
International Mouse Knockout Project StatusInpp5d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035865 VEGA Gene Model | MGI Sequence Detail 100196 C57BL/6J ±  kb
transcript OTTMUST00000091932 VEGA | MGI Sequence Detail 4937 Not Applicable 
polypeptide OTTMUSP00000050698 VEGA | MGI Sequence Detail 1191 Not Applicable 

For the selected sequences
All sequences(100) RefSeq(19) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(595 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
InterPro IPR000300 Inositol polyphosphate-related phosphatase
InterPro IPR000980 SH2 domain
Protein Ontology PR:000003302 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
References
(Earliest) J:35425 Chacko GW, et al., Negative signaling in B lymphocytes induces tyrosine phosphorylation of the 145-kDa inositol polyphosphate 5-phosphatase, SHIP. J Immunol. 1996 Sep 15;157(6):2234-8
(Latest) J:205106 Liu C, et al., N-wasp is essential for the negative regulation of B cell receptor signaling. PLoS Biol. 2013 Nov;11(11):e1001704
All references(169)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-35823, MGI:2138207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory