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Adgre1 Gene Detail
Summary
  • Symbol
    Adgre1
  • Name
    adhesion G protein-coupled receptor E1
  • Synonyms
    DD7A5-7, EGF-TM7, Emr1, F4/80, Ly71, TM7LN3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106912
    NCBI Gene: 13733
  • Gene Overview
    MyGene.info: ADGRE1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:57358686-57483529 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.80 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106912
protein coding gene Chr17:57358651-57483529 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023963
protein coding gene Chr17:59147629-59269106 (+)
A/J MGP_AJ_G0023921
protein coding gene Chr17:57494076-57611781 (+)
AKR/J MGP_AKRJ_G0023890
protein coding gene Chr17:58219052-58342360 (+)
BALB/cJ MGP_BALBcJ_G0023922
protein coding gene Chr17:57337279-57447764 (+)
C3H/HeJ MGP_C3HHeJ_G0023686
protein coding gene Chr17:58940332-59068461 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024368
protein coding gene Chr17:61442445-61567913 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021814
protein coding gene Chr17:53956828-54082874 (+)
CAST/EiJ MGP_CASTEiJ_G0023168
protein coding gene Chr17:59257968-59387157 (+)
CBA/J MGP_CBAJ_G0023662
protein coding gene Chr17:63847821-63985795 (+)
DBA/2J MGP_DBA2J_G0023790
protein coding gene Chr17:56181935-56294532 (+)
FVB/NJ MGP_FVBNJ_G0023756
protein coding gene Chr17:55760230-55882940 (+)
LP/J MGP_LPJ_G0023872
protein coding gene Chr17:59822175-59924870 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023784
protein coding gene Chr17:63254735-63374094 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024412
protein coding gene Chr17:58584447-58719767 (+)
PWK/PhJ MGP_PWKPhJ_G0022914
protein coding gene Chr17:55556467-55657494 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022725
protein coding gene Chr17:55363700-55491053 (+)
WSB/EiJ MGP_WSBEiJ_G0023234
protein coding gene Chr17:59226770-59328337 (+)



Homology
more
  • Human Ortholog
    ADGRE1, adhesion G protein-coupled receptor E1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADGRE1, adhesion G protein-coupled receptor E1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EMR1, TM7LN3
  • Links
    NCBI Gene ID: 2015
    neXtProt AC: NX_Q14246
    UniProt: Q14246

  • Chr Location
    19p13.3-p13.2; chr19:6887549-6940453 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 5 alleles in 5 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice fail to develop peripheral tolerance after inoculation with antigen because of a lack of efferent regulatory T cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004730 Ensembl Gene Model | MGI Sequence Detail 124844 C57BL/6J ±  kb
transcript ENSMUST00000004850 Ensembl | MGI Sequence Detail 3124 Not Applicable  
polypeptide ENSMUSP00000004850 Ensembl | MGI Sequence Detail 931 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 47
    cDNA 44
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-32093, MGD-MRK-35122, MGD-MRK-35373, MGI:105054, MGI:106663
References
more
  • Summaries
    All 190
    Developmental Gene Expression 131
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:18061 Chen HL, et al., Gestation-related expression of the interferon-gamma receptor gene in mouse uterine and embryonic hematopoietic cells. J Leukoc Biol. 1994 May;55(5):617-25
  • Latest
    J:264675 Fransen MF, et al., A Restricted Role for FcgammaR in the Regulation of Adaptive Immunity. J Immunol. 2018 Apr 15;200(8):2615-2626

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory