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Adgre1 Gene Detail
Summary
  • Symbol
    Adgre1
  • Name
    adhesion G protein-coupled receptor E1
  • Synonyms
    DD7A5-7, EGF-TM7, Emr1, F4/80, Ly71, TM7LN3
  • Feature Type
    protein coding gene
  • IDs
    MGI:106912
    NCBI Gene: 13733
  • Gene Overview
    MyGene.info: ADGRE1
Location & Maps
more
  • Sequence Map
    Chr17:57358686-57483529 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      124844 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.80 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ADGRE1, adhesion G protein-coupled receptor E1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADGRE1, adhesion G protein-coupled receptor E1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EMR1, TM7LN3
  • Links
    NCBI Gene ID: 2015
    neXtProt AC: NX_Q14246

  • Chr Location
    19p13.3; chr19:6887549-6940453 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (ENU)
    3
  • Targeted
    3
  • Incidental Mutations
Homozygous null mice fail to develop peripheral tolerance after inoculation with antigen because of a lack of efferent regulatory T cell development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004730 Ensembl Gene Model | MGI Sequence Detail 124844 C57BL/6J ±  kb
transcript ENSMUST00000086763 Ensembl | MGI Sequence Detail 3245 Not Applicable  
polypeptide ENSMUSP00000083971 Ensembl | MGI Sequence Detail 931 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    138 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000001813 adhesion G protein-coupled receptor E1
  • InterPro Domains
    IPR026823 Complement Clr-like EGF domain
    IPR018097 EGF-like calcium-binding, conserved site
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR000152 EGF-type aspartate/asparagine hydroxylation site
    IPR001740 GPCR family 2, EMR1-like receptor
    IPR017981 GPCR, family 2-like
    IPR000832 GPCR, family 2, secretin-like
    IPR017983 GPCR, family 2, secretin-like, conserved site
    IPR000203 GPS motif
    IPR009030 Growth factor receptor cysteine-rich domain
Molecular
Reagents
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  • All nucleic 45
    cDNA 43
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-32093, MGD-MRK-35122, MGD-MRK-35373, MGI:105054, MGI:106663
References
more
  • Summaries
    All 144
    Developmental Gene Expression 98
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:23161 Timsit S, et al., Oligodendrocytes originate in a restricted zone of the embryonic ventral neural tube defined by DM-20 mRNA expression. J Neurosci. 1995 Feb;15(2):1012-24
  • Latest
    J:232562 Dayton TL, et al., Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma. Genes Dev. 2016 May 1;30(9):1020-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory