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Tpgs1 Gene Detail
Summary
  • Symbol
    Tpgs1
  • Name
    tubulin polyglutamylase complex subunit 1
  • Synonyms
    Gm16517, Gtrgeo22
  • Feature Type
    protein coding gene
  • IDs
    MGI:106618
    NCBI Gene: 110012
Location & Maps
more
  • Sequence Map
    Chr10:79669410-79676126 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6717 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TPGS1, tubulin polyglutamylase complex subunit 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TPGS1, tubulin polyglutamylase complex subunit 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C19orf20, GTRGEO22, PGs1
  • Links
    NCBI Gene ID: 91978
    neXtProt AC: NX_Q6ZTW0

  • Chr Location
    19p13.3; chr19:507497-519654 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    204
  • Chemically induced (other)
    1
  • Gene trapped
    201
  • Targeted
    2
  • Genomic Mutations
    1 involving Tpgs1
  • Incidental Mutations
    APF
Male mice homozygous for a gene trapped allele are sterile due to abnormal development of the spermatid flagellum. Adult males display a striking deficit in intermale aggression and reduced body fat, not due to an altered resting metabolic rate or hypophagia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 110012 NCBI Gene Model | MGI Sequence Detail 6717 C57BL/6J ±  kb
transcript NM_148934 RefSeq | MGI Sequence Detail 1101 Not Specified  
polypeptide Q99MS8 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    10 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000031177 tubulin polyglutamylase complex subunit 1
  • InterPro Domains
    IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
Molecular
Reagents
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  • All nucleic 38
    cDNA 37
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35075
References
more
  • Summaries
    All 30
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:79292 Campbell PK, et al., Mutation of a novel gene results in abnormal development of spermatid flagella, loss of intermale aggression and reduced body fat in mice. Genetics. 2002 Sep;162(1):307-20
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory