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Gstt2 Gene Detail
Summary
  • Symbol
    Gstt2
  • Name
    glutathione S-transferase, theta 2
  • Synonyms
    mGSTT2, Yrs
  • Feature Type
    protein coding gene
  • IDs
    MGI:106188
    NCBI Gene: 14872
Location & Maps
more
  • Sequence Map
    Chr10:75831845-75834881 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3037 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 38.58 cM, cytoband B5-C1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GSTT2, glutathione S-transferase theta 2 (gene/pseudogene)
  • Vertebrate Orthologs
    7
  • Human Ortholog
    GSTT2, glutathione S-transferase theta 2 (gene/pseudogene)
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2953
    neXtProt AC: NX_P0CG29

  • Chr Location
    22q11.23; chr22:23980028-23983915 (+)  GRCh38.p2

  • Human Ortholog
    GSTT2B, glutathione S-transferase theta 2B (gene/pseudogene)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GSTT2P
  • Links
    NCBI Gene ID: 653689
    neXtProt AC: NX_P0CG30

  • Chr Location
    22q11.23; chr22:23957414-23961234 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    18
  • Targeted
    4
  • Genomic Mutations
    1 involving Gstt2
  • Incidental Mutations
Mice homozygous for a disruption in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033318 Ensembl Gene Model | MGI Sequence Detail 3037 C57BL/6J ±  kb
transcript ENSMUST00000038257 Ensembl | MGI Sequence Detail 1370 Not Applicable  
polypeptide ENSMUSP00000046324 Ensembl | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • EC
  • InterPro Domains
    IPR004046 Glutathione S-transferase, C-terminal
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR004045 Glutathione S-transferase, N-terminal
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 11
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-33879, MGI:2143556
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:32421 Whittington AT, et al., Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1. Genomics. 1996 Apr 1;33(1):105-11
  • Latest
    J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory