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Gstt2
Gene Detail
Symbol

Name
ID
Gstt2
glutathione S-transferase, theta 2
MGI:106188
Synonyms
mGSTT2, Yrs
Feature Type
protein coding gene
Genetic Map
Chromosome 10
38.58 cM, cytoband B5-C1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:75831845-75834881 bp, - strand
From Ensembl annotation of GRCm38

  3037 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37358  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

HCOP human homology predictions: GSTT2, GSTT2B
Gene Tree: Gstt2

Human
homologs
GSTT2, glutathione S-transferase theta 2 (gene/pseudogene)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2953
neXtProt AC: NX_P0CG29

Human Chr (Location): 22q11.23; chr22:23980028-23983915 (+)  GRCh38.p2

  1 More Homolog(s):
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(18) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene display a normal phenotype.
 
Interactions
Gstt2 interacts with 3 markers (Mir298, Mir1933, Mir3070b)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process glutathione metabolic process, oxidation-reduction process
Component cytoplasm, cytosol, ...
Function glutathione peroxidase activity, glutathione transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (140)    Tissues (139)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 46
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000033318 (Evidence)
Entrez Gene 14872 (Evidence)
DFCI TC1578882, TC1589018, TC1680528
DoTS DT.534158, DT.534160
NIA Mouse Gene Index U031933
EC 2.5.1.18
Consensus CDS Project CCDS48601.1
International Mouse Phenotyping Consortium Status Gstt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033318 Ensembl Gene Model | MGI Sequence Detail 3037 C57BL/6J ±  kb
transcript ENSMUST00000038257 Ensembl | MGI Sequence Detail 1370 Not Applicable 
polypeptide ENSMUSP00000046324 Ensembl | MGI Sequence Detail 244 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(8) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004046 Glutathione S-transferase, C-terminal
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR004045 Glutathione S-transferase, N-terminal
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008306 glutathione S-transferase theta-2
References
(Earliest) J:32421 Whittington AT, et al., Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1. Genomics. 1996 Apr 1;33(1):105-11
(Latest) J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
All references(41)
Other
accession IDs
MGD-MRK-33879, MGI:2143556

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory