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Gstt2
Gene Detail
Symbol

Name
ID
Gstt2
glutathione S-transferase, theta 2
MGI:106188
Synonyms
mGSTT2, Yrs
Feature Type
protein coding gene
Genetic Map
Chromosome 10
38.58 cM, cytoband B5-C1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:75831845-75834881 bp, - strand
From Ensembl annotation of GRCm38

  3037 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37358  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Gstt2

Human
homologs
Human Homolog GSTT2, glutathione S-transferase theta 2 (gene/pseudogene)
NCBI Gene ID 2953
neXtProt AC  NX_P0CG29, NX_P0CG30
Human Chr (Location)  22q11.23; chr22:23980123-23983915 (+)  GRCh38
Human Homolog GSTT2B, glutathione S-transferase theta 2B (gene/pseudogene)
NCBI Gene ID 653689
neXtProt AC  NX_P0CG30
Human Synonyms  GSTT2P
Human Chr (Location)  22q11.23; chr22:23957414-23961228 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(18) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene display a normal phenotype.
 
Interactions
Gstt2 interacts with 3 markers (Mir298, Mir1933, Mir3070b)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process glutathione metabolic process
Component cytoplasm, cytosol, ...
Function glutathione transferase activity, transferase activity
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (140)    Tissues (139)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 46
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(11) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000033318 (Evidence)
Entrez Gene14872 (Evidence)
DFCITC1578882, TC1680528, TC1589018
DoTSDT.534158, DT.534160
NIA Mouse Gene IndexU031933
EC2.5.1.18
Consensus CDS ProjectCCDS48601.1
International Mouse Knockout Project StatusGstt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033318 Ensembl Gene Model | MGI Sequence Detail 3037 C57BL/6J ±  kb
transcript ENSMUST00000038257 Ensembl | MGI Sequence Detail 1370 Not Applicable 
polypeptide ENSMUSP00000046324 Ensembl | MGI Sequence Detail 244 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004046 Glutathione S-transferase, C-terminal
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR004045 Glutathione S-transferase, N-terminal
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008306 glutathione S-transferase theta-2
References
(Earliest) J:32421 Whittington AT, et al., Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1. Genomics. 1996 Apr 1;33(1):105-11
(Latest) J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
All references(42)
Other
accession IDs
MGD-MRK-33879, MGI:2143556

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory