Gstt2
Gene Detail

Symbol Name ID

Gstt2 glutathione S-transferase, theta 2 MGI:106188

Synonyms

mGSTT2, Yrs

Feature Type

protein coding gene

Genetic Map

Chromosome 10

38.58 cM, cytoband B5-C1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:75831845-75834881 bp, - strand From NCBI annotation of GRCm38   3037 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37358  Vertebrate Homology Class
2 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 dog

Gene Tree: Gstt2

Human homologs

Human Homolog		GSTT2, glutathione S-transferase theta 2
NCBI Gene ID		2953
neXtProt AC		NX_P0CG29, NX_P0CG30
Human Synonyms		GSTT2B
Human Chr (Location)		22q11.23; chr22:24322314-24326106 (+)  GRCh37.p10
Human Homolog		GSTT2B, glutathione S-transferase theta 2B (gene/pseudogene)
NCBI Gene ID		653689
neXtProt AC		NX_P0CG30
Human Synonyms		GSTT2P
Human Chr (Location)		22q11.23; chr22:24299601-24303368 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(22) : Targeted(4) Gene trapped(18)
 

Mice homozygous for a disruption in this gene display a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	glutathione metabolic process
Component	cytoplasm, cytosol, ...
Function	glutathione transferase activity, transferase activity

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (140)    Tissues (139)    Images (1)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	94
RT-PCR	46

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(1) cDNA(11) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000033318 (Evidence)
Entrez Gene	14872 (Evidence)
DFCI	TC1578882, TC1589018, TC1680528
DoTS	DT.534158, DT.534160
NIA Mouse Gene Index	U031933
EC	2.5.1.18
Consensus CDS Project	CCDS48601.1
International Mouse Knockout Project Status	Gstt2

Sequences

Length	Strain/Species
genomic	14872	NCBI Gene Model | MGI Sequence Detail	3037	C57BL/6J
transcript	NM_010361	RefSeq | MGI Sequence Detail	1370	C57BL/6
polypeptide	Q61133	UniProt | EBI | MGI Sequence Detail	244	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(41 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017933	Glutathione S-transferase/chloride channel, C-terminal
InterPro	IPR004046	Glutathione S-transferase, C-terminal
InterPro	IPR010987	Glutathione S-transferase, C-terminal-like
InterPro	IPR004045	Glutathione S-transferase, N-terminal
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000008306	glutathione S-transferase theta-2

Graphical View of Protein Domain Structure

References

(Earliest) J:32421 Whittington AT, et al., Characterization of a cDNA and gene encoding the mouse theta class glutathione transferase mGSTT2 and its localization to chromosome 10B5-C1. Genomics. 1996 Apr 1;33(1):105-11
(Latest) J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
All references(42)

Other accession IDs

MGD-MRK-33879, MGI:2143556