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Gucy2d Gene Detail
Summary
  • Symbol
    Gucy2d
  • Name
    guanylate cyclase 2d
  • Synonyms
    guanylyl cyclase D
  • Feature Type
    protein coding gene
  • IDs
    MGI:106030
    NCBI Gene: 14918
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:98440416-98477479 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 53.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    470 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106030
protein coding gene Chr7:98440416-98477479 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032539
protein coding gene Chr7:101168432-101207884 (+)
A/J MGP_AJ_G0032513
protein coding gene Chr7:98673787-98711348 (+)
AKR/J MGP_AKRJ_G0032449
protein coding gene Chr7:101019502-101056229 (+)
BALB/cJ MGP_BALBcJ_G0032524
protein coding gene Chr7:98361742-98399269 (+)
C3H/HeJ MGP_C3HHeJ_G0032239
protein coding gene Chr7:101370697-101411898 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033022
protein coding gene Chr7:105089806-105126825 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030017
protein coding gene Chr7:101109909-101147454 (+)
CAST/EiJ MGP_CASTEiJ_G0031566
protein coding gene Chr7:92890224-92929660 (+)
CBA/J MGP_CBAJ_G0032206
protein coding gene Chr7:108674213-108718262 (+)
DBA/2J MGP_DBA2J_G0032358
protein coding gene Chr7:97005935-97045767 (+)
FVB/NJ MGP_FVBNJ_G0032314
protein coding gene Chr7:96806387-96844114 (+)
LP/J MGP_LPJ_G0032447
protein coding gene Chr7:102499567-102538096 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032347
protein coding gene Chr7:110196574-110233740 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033044
protein coding gene Chr7:100286506-100323676 (+)
PWK/PhJ MGP_PWKPhJ_G0031284
protein coding gene Chr7:90086548-90126678 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031127
protein coding gene Chr7:87564298-87602600 (+)
WSB/EiJ MGP_WSBEiJ_G0031683
protein coding gene Chr7:100945521-100983407 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozugous for a null allele lack olfactory response to uroguanylin and guanylin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14918 NCBI Gene Model | MGI Sequence Detail 37064 C57BL/6J ±  kb
    transcript NM_001130693 RefSeq | MGI Sequence Detail 3633 C57BL/6  
    polypeptide NP_001124165 RefSeq | MGI Sequence Detail 1117 C57BL/6  
    For the selected sequence
    Protein
    Information
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    • UniProt
      4 Sequences
    • EC
    • InterPro Domains
      IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
      IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site
      IPR029787 Nucleotide cyclase
      IPR028082 Periplasmic binding protein-like I
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001828 Receptor, ligand binding region
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 5
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-33714
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:237633 Dizhoor AM, et al., The R838S Mutation in Retinal Guanylyl Cyclase 1 (RetGC1) Alters Calcium Sensitivity of cGMP Synthesis in the Retina and Causes Blindness in Transgenic Mice. J Biol Chem. 2016 Nov 18;291(47):24504-24516

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory