Gucy2d
Gene Detail

Symbol Name ID

Gucy2d guanylate cyclase 2d MGI:106030

Synonyms

guanylyl cyclase D

Feature Type

protein coding gene

Genetic Map

Chromosome 7

53.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:98443422-98477478 bp, + strand From NCBI annotation of GRCm38   34057 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:71540  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Gucy2d

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozugous for a null allele lack olfactory response to uroguanylin and guanylin.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	cGMP biosynthetic process
Component	integral to membrane
Function	guanylate cyclase activity, lyase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Images (1)
Theiler Stages: 20

Assay Type	Results
RT-PCR	2

cDNA source data(4)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000074003 (Evidence)
Entrez Gene	14918 (Evidence)
UniGene	389928
DFCI	TC1595125
DoTS	DT.101303558
NIA Mouse Gene Index	U113905
EC	4.6.1.2
International Mouse Knockout Project Status	Gucy2d

Sequences

Length	Strain/Species
genomic	14918	NCBI Gene Model | MGI Sequence Detail	34057	C57BL/6J
transcript	NM_001130693	RefSeq | MGI Sequence Detail	3540	Not Specified
polypeptide	NP_001124165	RefSeq | MGI Sequence Detail	1117	Not Specified

All sequences(18) RefSeq(3) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(281 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro	IPR018297	Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain

References

(Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:184979 Olshevskaya EV, et al., Retinal Guanylyl Cyclase Isozyme 1 Is the Preferential In Vivo Target for Constitutively Active GCAP1 Mutants Causing Congenital Degeneration of Photoreceptors. J Neurosci. 2012 May 23;32(21):7208-17
All references(29)

Other accession IDs

MGD-MRK-33714