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Gucy2d
Gene Detail
Symbol

Name
ID
Gucy2d
guanylate cyclase 2d
MGI:106030
Synonyms
guanylyl cyclase D
Feature Type
protein coding gene
Genetic Map
Chromosome 7
53.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:98443421-98477478 bp, + strand
From Ensembl annotation of GRCm38

  34058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:71540  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Gucy2d

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozugous for a null allele lack olfactory response to uroguanylin and guanylin.
 
Interactions
Gucy2d interacts with 39 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process cGMP biosynthetic process
Component integral component of membrane
Function guanylate cyclase activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(4)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000074003 (Evidence)
Entrez Gene 14918 (Evidence)
UniGene 389928
DFCI TC1595125
DoTS DT.101303558
NIA Mouse Gene Index U113905
EC 4.6.1.2
International Mouse Phenotyping Consortium Status Gucy2d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074003 Ensembl Gene Model | MGI Sequence Detail 34058 C57BL/6J ±  kb
transcript ENSMUST00000098274 Ensembl | MGI Sequence Detail 3537 Not Applicable 
polypeptide ENSMUSP00000095875 Ensembl | MGI Sequence Detail 1116 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(5) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(440 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
References
(Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:184979 Olshevskaya EV, et al., Retinal Guanylyl Cyclase Isozyme 1 Is the Preferential In Vivo Target for Constitutively Active GCAP1 Mutants Causing Congenital Degeneration of Photoreceptors. J Neurosci. 2012 May 23;32(21):7208-17
All references(25)
Other
accession IDs
MGD-MRK-33714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory