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Gucy2d
Gene Detail
Symbol

Name
ID
Gucy2d
guanylate cyclase 2d
MGI:106030
Synonyms
guanylyl cyclase D
Feature Type
protein coding gene
Genetic Map
Chromosome 7
53.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:98443422-98477478 bp, + strand
From NCBI annotation of GRCm38

  34057 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:71540  Vertebrate Homology Class
1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Gucy2d

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozugous for a null allele lack olfactory response to uroguanylin and guanylin.
 
Interactions
Gucy2d interacts with 39 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cGMP biosynthetic process
Component integral component of membrane, membrane
Function guanylate cyclase activity, lyase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (2)    Tissues (2)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 2
cDNA source data(4)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(5) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000074003 (Evidence)
Entrez Gene14918 (Evidence)
UniGene389928
DFCITC1595125
DoTSDT.101303558
NIA Mouse Gene IndexU113905
EC4.6.1.2
International Mouse Knockout Project StatusGucy2d
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14918 NCBI Gene Model | MGI Sequence Detail 34057 C57BL/6J ±  kb
transcript NM_001130693 RefSeq | MGI Sequence Detail 3633 C57BL/6 
polypeptide NP_001124165 RefSeq | MGI Sequence Detail 1117 C57BL/6 

For the selected sequences
All sequences(18) RefSeq(3) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(440 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
References
(Earliest) J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
(Latest) J:184979 Olshevskaya EV, et al., Retinal Guanylyl Cyclase Isozyme 1 Is the Preferential In Vivo Target for Constitutively Active GCAP1 Mutants Causing Congenital Degeneration of Photoreceptors. J Neurosci. 2012 May 23;32(21):7208-17
All references(29)
Other
accession IDs
MGD-MRK-33714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory