glucose-6-phosphate dehydrogenase X-linked
Null mutants show placental defects and arrest developmentally; hemizygous males dying by day 10.5 and heterozygous females by day 11.5 with the normal X selectively inactive. Hypomorphic mutants show increased mutagenesis and oxidative stress in spleen.
|Process||angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure, carbohydrate metabolic process, ...|
|Component||cytoplasm, cytoplasmic side of plasma membrane, ...|
|Function||carbohydrate binding, glucose-6-phosphate dehydrogenase activity, ...|
|InterPro||IPR019796||Glucose-6-phosphate dehydrogenase, active site|
|InterPro||IPR022675||Glucose-6-phosphate dehydrogenase, C-terminal|
|InterPro||IPR022674||Glucose-6-phosphate dehydrogenase, NAD-binding|
|Protein Ontology||PR:000007749||glucose-6-phosphate 1-dehydrogenase|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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