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G6pdx
Gene Detail
Symbol

Name
ID
G6pdx
glucose-6-phosphate dehydrogenase X-linked
MGI:105979
Synonyms
G28A, G6pd, Gpdx
Feature Type
protein coding gene
Genetic Map
Chromosome X
38.00 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(41)
Sequence Map
ChrX:74409483-74429194 bp, - strand
From VEGA annotation of GRCm38

  19712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37906  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: G6PD
Protein SuperFamily: glucose-6-phosphate dehydrogenase
Gene Tree: G6pdx

Human
homologs
G6PD, glucose-6-phosphate dehydrogenase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2539
neXtProt AC: NX_P11413

Human Synonyms: G6PD1

Human Chr (Location): Xq28; chrX:154531390-154547586 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human G6PD

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Gene trapped(2) Radiation induced(1) Targeted(3)
 
Null mutants show placental defects and arrest developmentally; hemizygous males dying by day 10.5 and heterozygous females by day 11.5 with the normal X selectively inactive. Hypomorphic mutants show increased mutagenesis and oxidative stress in spleen.
 
Interactions
G6pdx interacts with 143 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Expression
Literature Summary: (7 records)
Data Summary: Results (123)    Tissues (109)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 6
RT-PCR 23
cDNA source data(112)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase g6pd ; ZFIN g6pd    NEW 
Molecular
reagents
All nucleic(129) Genomic(8) cDNA(117) Primer pair(1) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017699 (Evidence)
Ensembl Gene Model ENSMUSG00000031400 (Evidence)
Entrez Gene 14381 (Evidence)
UniGene 27210
DoTS DT.101122317, DT.94357873
NIA Mouse Gene Index U039474
EC 1.1.1.49
Consensus CDS Project CCDS30232.1
International Mouse Phenotyping Consortium Status G6pdx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017699 VEGA Gene Model | MGI Sequence Detail 19712 C57BL/6J ±  kb
transcript OTTMUST00000042897 VEGA | MGI Sequence Detail 2652 Not Applicable 
polypeptide OTTMUSP00000019282 VEGA | MGI Sequence Detail 515 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(4) : SNPs within 2kb(67 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001282 Glucose-6-phosphate dehydrogenase
InterPro IPR019796 Glucose-6-phosphate dehydrogenase, active site
InterPro IPR022675 Glucose-6-phosphate dehydrogenase, C-terminal
InterPro IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000007749 glucose-6-phosphate 1-dehydrogenase
References
(Earliest) J:5105 Ruddle FH, et al., Allelically-determined isozyme polymorphisms in laboratory populations of mice. Ann N Y Acad Sci. 1968 Jun 14;151(1):531-9
(Latest) J:192095 Rawat DK, et al., Glucose-6-phosphate dehydrogenase and NADPH redox regulates cardiac myocyte L-type calcium channel activity and myocardial contractile function. PLoS One. 2012;7(10):e45365
All references(110)
Other
accession IDs
MGD-MRK-10225, MGD-MRK-33659, MGD-MRK-9915

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory