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G6pdx Gene Detail
Summary
  • Symbol
    G6pdx
  • Name
    glucose-6-phosphate dehydrogenase X-linked
  • Synonyms
    G28A, G6pd, Gpdx
  • Feature Type
    protein coding gene
  • IDs
    MGI:105979
    NCBI Gene: 14381
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74409486-74429161 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 38.00 cM, cytoband A2-A3
  • Mapping Data
    41 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105979
protein coding gene ChrX:74409483-74429194 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035848
protein coding gene ChrX:70217650-70237564 (-)
A/J MGP_AJ_G0035829
protein coding gene ChrX:70397504-70422007 (-)
AKR/J MGP_AKRJ_G0035754
protein coding gene ChrX:72295860-72316746 (-)
BALB/cJ MGP_BALBcJ_G0035814
protein coding gene ChrX:69422708-69442746 (-)
C3H/HeJ MGP_C3HHeJ_G0035519
protein coding gene ChrX:70689186-70710204 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036344
protein coding gene ChrX:72385876-72422237 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033188
protein coding gene ChrX:69464430-69483561 (-)
CAST/EiJ MGP_CASTEiJ_G0034810
protein coding gene ChrX:56069245-56089835 (-)
CBA/J MGP_CBAJ_G0035494
protein coding gene ChrX:74381858-74408639 (-)
DBA/2J MGP_DBA2J_G0035651
protein coding gene ChrX:69860363-69880142 (-)
FVB/NJ MGP_FVBNJ_G0035595
protein coding gene ChrX:69202552-69224083 (-)
LP/J MGP_LPJ_G0035736
protein coding gene ChrX:70987701-71009894 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035633
protein coding gene ChrX:76934133-76955105 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036366
protein coding gene ChrX:70031138-70051679 (-)
PWK/PhJ MGP_PWKPhJ_G0034509
protein coding gene ChrX:54029713-54048552 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034343
protein coding gene ChrX:56942200-56964208 (-)
WSB/EiJ MGP_WSBEiJ_G0034951
protein coding gene ChrX:69315761-69335628 (-)



Homology
more
  • Human Ortholog
    G6PD, glucose-6-phosphate dehydrogenase
  • Vertebrate Orthologs
    8
  • Human Ortholog
    G6PD, glucose-6-phosphate dehydrogenase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    G6PD1
  • Links
    NCBI Gene ID: 2539
    neXtProt AC: NX_P11413
    UniProt: P11413

  • Chr Location
    Xq28; chrX:154531390-154547586 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with G6pdx mouse models; 2 with human G6PD associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Null mutants show placental defects and arrest developmentally; hemizygous males dying by day 10.5 and heterozygous females by day 11.5 with the normal X selectively inactive. Hypomorphic mutants show increased mutagenesis and oxidative stress in spleen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14381 NCBI Gene Model | MGI Sequence Detail 19676 C57BL/6J ±  kb
    transcript NM_008062 RefSeq | MGI Sequence Detail 2354 C57BL/6  
    polypeptide Q00612 UniProt | EBI | MGI Sequence Detail 515 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 130
      Genomic 8
      cDNA 118
      Primer pair 1
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10225, MGD-MRK-33659, MGD-MRK-9915
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 9
      Diseases 3
      Gene Ontology 25
      Phenotypes 35
    • Earliest
      J:5105 Ruddle FH, et al., Allelically-determined isozyme polymorphisms in laboratory populations of mice. Ann N Y Acad Sci. 1968 Jun 14;151(1):531-9
    • Latest
      J:263847 Spencer NY, et al., Linagliptin unmasks specific antioxidant pathways protective against albuminuria and kidney hypertrophy in a mouse model of diabetes. PLoS One. 2018;13(7):e0200249

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory