Hfm
Gene Detail

Symbol Name ID

Hfm hemifacial microsomia-associated locus MGI:105953

Feature Type

heritable phenotypic marker

Genetic Map

Chromosome 10
cytoband B1-3

Mapping data(1)

Alleles and phenotypes

All alleles(1) : Transgenic(1)
 

Mice heterozygous for an autosomal dominant insertional mutation that disrupts this locus exhibit hemifacial microsomia, including microtia, low set ear and abnormal bite, probably due to hypoplasia of the second branchial arch. Homozygotes die during the prenatal period.

 
Human Diseases Modeled Using Mouse Hfm (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (3 annotations)

Process

ear development, embryonic cranial skeleton morphogenesis, ...

Other database links

Entrez Gene

107693

References

(Earliest) J:77548 Kimura M, et al., Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5661-5
(Latest) J:21097 Naora H, et al., Transgenic mouse model of hemifacial microsomia: cloning and characterization of insertional mutation region on chromosome 10. Genomics. 1994 Oct;23(3):515-9
All references(4)

Other accession IDs

MGD-MRK-33632