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Hfm
Gene Detail
Symbol

Name
ID
Hfm
hemifacial microsomia-associated locus
MGI:105953
Feature Type
heritable phenotypic marker
Genetic Map
Chromosome 10
cytoband B1-3

Mapping data(1)
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Transgenic(1)
 
Mice heterozygous for an autosomal dominant insertional mutation that disrupts this locus exhibit hemifacial microsomia, including microtia, low set ear and abnormal bite, probably due to hypoplasia of the second branchial arch. Homozygotes die during the prenatal period.
 
Human Diseases Modeled Using Mouse Hfm (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process ear development, embryonic cranial skeleton morphogenesis, ...
Other database
links
Entrez Gene107693
References
(Earliest) J:77548 Kimura M, et al., Restoration of myelin formation by a single type of myelin basic protein in transgenic shiverer mice. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5661-5
(Latest) J:21097 Naora H, et al., Transgenic mouse model of hemifacial microsomia: cloning and characterization of insertional mutation region on chromosome 10. Genomics. 1994 Oct;23(3):515-9
All references(4)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-33632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory