Hspa8 MGI Mouse Gene Detail - MGI:105384

Symbol

Hspa8
Name

heat shock protein 8
Synonyms

2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73

Feature Type

protein coding gene
IDs

MGI:105384
NCBI Gene: 15481
Gene Overview

MyGene.info: HSPA8
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:40801276-40805202 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 21.55 cM
Mapping Data

4 experiments

SNPs within 2kb

55 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105384	protein coding gene	Chr9:40800984-40810087 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034670	protein coding gene	Chr9:39039892-39040733 (+)
A/J	MGP_AJ_G0034650	protein coding gene	Chr9:38039827-38041214 (+)
AKR/J	MGP_AKRJ_G0034576	protein coding gene	Chr9:38753721-38763868 (+)
BALB/cJ	MGP_BALBcJ_G0034641	protein coding gene	Chr9:37782395-37783236 (+)
C3H/HeJ	MGP_C3HHeJ_G0034352	protein coding gene	Chr9:39276683-39277537 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035164	protein coding gene	Chr9:40278176-40287719 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024370	protein coding gene	Chr2:133599670-133602972 (+)
CAST/EiJ	MGP_CASTEiJ_G0033675	protein coding gene	Chr9:38998853-39005106 (+)
CBA/J	MGP_CBAJ_G0034325	protein coding gene	Chr9:41677645-41683382 (+)
DBA/2J	MGP_DBA2J_G0034484	protein coding gene	Chr9:37974538-37975672 (+)
FVB/NJ	MGP_FVBNJ_G0034424	protein coding gene	Chr9:37196852-37201187 (+)
LP/J	MGP_LPJ_G0034565	protein coding gene	Chr9:39320049-39321267 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034468	protein coding gene	Chr9:43720519-43721360 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035183	protein coding gene	Chr9:38673281-38685978 (+)
PWK/PhJ	MGP_PWKPhJ_G0033380	protein coding gene	Chr9:37781602-37782832 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033216	protein coding gene	Chr9:38906364-38910141 (+)
WSB/EiJ	MGP_WSBEiJ_G0033788	protein coding gene	Chr9:38701356-38706018 (+)

Human Ortholog

HSPA8, heat shock protein family A (Hsp70) member 8

Vertebrate Orthologs

10

Human Ortholog

HSPA8, heat shock protein family A (Hsp70) member 8
Orthology source: HomoloGene, HGNC
Synonyms

HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP1, LAP-1, NIP71
Links

HGNC:5241

NCBI Gene ID: 3312

neXtProt AC: NX_P11142

UniProt: P11142
Chr Location

11q24.1; chr11:123057492-123062366 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 68524
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: HSPA8
Protein SuperFamily

chaperone HSP70
Gene Tree

Hspa8

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

7
Gene trapped

5
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

14 strains or lines available

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All GO Annotations

163
GO References

25

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

756
Tissues

90
cDNA Data

101
Literature Summary

22

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hspa8

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Hspa8 interacts with 49 markers (Mir15a, Mir15b, Mir16-1, ...) View All

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All Sequences

332
RefSeq

4
UniProt

19
CCDS

CCDS23083.1, CCDS90540.1

Ensembl

ENSMUSG00000015656 (Evidence)
NCBI Gene

15481

			Length	Strain/Species	Flank
genomic	15481	NCBI Gene Model \| MGI Sequence Detail	3927	C57BL/6J	± kb
transcript	NM_031165	RefSeq \| MGI Sequence Detail	2119	C57BL/6
polypeptide	P63017	UniProt \| EBI \| MGI Sequence Detail	646	Not Applicable

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UniProt

19 Sequences
Protein Ontology

PR:000008812 heat shock cognate 71 kDa protein

(term hierarchy)
PDB

3CQX
InterPro Domains

IPR043129 ATPase, nucleotide binding domain

IPR018181 Heat shock protein 70, conserved site

IPR013126 Heat shock protein 70 family

IPR029048 Heat shock protein 70kD, C-terminal domain superfamily

IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily

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All nucleic 114

Genomic 7

cDNA 103

Primer pair 4

Microarray probesets 7

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MGD-MRK-33053, MGI:1916447

Summaries

All 101

Developmental Gene Expression 22

Gene Ontology 25

Phenotypes 5
Earliest

J:17982 Giebel LB, et al., Developmental regulation of a constitutively expressed mouse mRNA encoding a 72-kDa heat shock-like protein. Dev Biol. 1988 Jan;125(1):200-7
Latest

J:263412 Yagi H, et al., Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70. PLoS One. 2017;12(2):e0172257

TSS for Hspa8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84481	Chr9:40801266-40801284 (+)	-1 bp
Tssr84482	Chr9:40801905-40801913 (+)	633 bp
Tssr84483	Chr9:40802366-40802369 (+)	1,092 bp
Tssr84484	Chr9:40802625-40802656 (+)	1,365 bp
Tssr84485	Chr9:40804224-40804235 (+)	2,954 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 01/12/2021 MGI 6.16