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Hspa8 Gene Detail
Summary
  • Symbol
    Hspa8
  • Name
    heat shock protein family A (Hsp70) member 8
  • Synonyms
    2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73
  • Feature Type
    protein coding gene
  • IDs
    MGI:105384
    NCBI Gene: 15481
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr9:40712572-40716498 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 21.55 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    227 from dbSNP Build 142
  • Strain Annotations
    16
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105384
 protein coding gene Chr9:40712280-40721383 (+)
129S1/SvImJ ENSMUSG00200039894
 protein coding gene Chr9:37791973-37796214 (+)
A/J ENSMUSG00195048033
 protein coding gene Chr9:37548864-37553108 (+)
AKR/J ENSMUSG00220042922
 protein coding gene Chr9:37630694-37634934 (+)
BALB/cJ ENSMUSG00180043308
 protein coding gene Chr9:37672118-37676361 (+)
C3H/HeJ ENSMUSG00175043859
 protein coding gene Chr9:37672677-37676920 (+)
C57BL/6NJ ENSMUSG00215018742
 protein coding gene Chr9:37629714-37633931 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024370
 protein coding gene Chr2:133599670-133602972 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210041967
 protein coding gene Chr9:37719790-37724030 (+)
DBA/2J ENSMUSG00185036616
 protein coding gene Chr9:37768550-37772789 (+)
FVB/NJ ENSMUSG00205035737
 protein coding gene Chr9:38035181-38039418 (+)
JF1/MsJ ENSUMUG00000041480
 protein coding gene Chr9:37820402-37824618 (+)
LP/J ENSMUSG00230032816
 protein coding gene Chr9:38080562-38087606 (+)
NOD/ShiLtJ ENSMUSG00190027208
 protein coding gene Chr9:37851789-37856030 (+)
NZO/HlLtJ ENSMUSG00225021395
 protein coding gene Chr9:38049048-38056092 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010033770
 protein coding gene Chr9:38503902-38508097 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HSPA8, heat shock protein family A (Hsp70) member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPA8, heat shock protein family A (Hsp70) member 8
  • Synonyms
    HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
  • Links
    NCBI Gene ID: 3312
    UniProt: P11142

  • Chr Location
    11q24.1; chr11:123057485-123063230 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HSPA8 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    243
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    122
  • cDNA Data
    101
  • Literature Summary
    31
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15481 NCBI Gene Model | MGI Sequence Detail 3927 C57BL/6J ±  kb
transcript NM_031165 RefSeq | MGI Sequence Detail 2119 C57BL/6  
polypeptide P63017 UniProt | EBI | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    20 Sequences
  • Protein Ontology
    PR:000008812 heat shock cognate 71 kDa protein
    (term hierarchy)
  • PDB
    3CQX
  • EC
    3.6.4.10
  • InterPro Domains
    IPR043129 ATPase, nucleotide binding domain
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
    IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
  • GlyGen
    P63017 7 sites, 5 N-linked glycans (5 sites), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 117
    Genomic 8
    cDNA 103
    Primer pair 6
    Antibodies 6

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-33053, MGI:1916447
References
more
  • Summaries
    All 186
    Developmental Gene Expression 31
    Gene Ontology 35
    Phenotypes 8
  • Earliest
    J:17982 Giebel LB, et al., Developmental regulation of a constitutively expressed mouse mRNA encoding a 72-kDa heat shock-like protein. Dev Biol. 1988 Jan;125(1):200-7
  • Latest
    J:390085 Zhuang Y, et al., Chaperone-mediated autophagy manipulates PGC1alpha stability and governs energy metabolism under thermal stress. Nat Commun. 2025 May 14;16(1):4455
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory