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Hspa8 Gene Detail
Summary
  • Symbol
    Hspa8
  • Name
    heat shock protein 8
  • Synonyms
    2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73
  • Feature Type
    protein coding gene
  • IDs
    MGI:105384
    NCBI Gene: 15481
  • Gene Overview
    MyGene.info: HSPA8
Location & Maps
more
  • Sequence Map
    Chr9:40800984-40805200 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4217 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 21.55 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HSPA8, heat shock protein family A (Hsp70) member 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSPA8, heat shock protein family A (Hsp70) member 8
    Orthology source: HomoloGene
  • Synonyms
    HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP1, LAP-1, NIP71
  • Links
    NCBI Gene ID: 3312
    neXtProt AC: NX_P11142

  • Chr Location
    11q24.1; chr11:123057492-123062366 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030238 VEGA Gene Model | MGI Sequence Detail 4217 C57BL/6J ±  kb
transcript OTTMUST00000074856 VEGA | MGI Sequence Detail 2394 Not Applicable  
polypeptide OTTMUSP00000039133 VEGA | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    56 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    20 Sequences
  • Protein Ontology
    PR:000008812 heat shock cognate 71 kDa protein
  • PDB
  • InterPro Domains
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain
    IPR029047 Heat shock protein 70kD, peptide-binding domain
Molecular
Reagents
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  • All nucleic 110
    Genomic 7
    cDNA 101
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-33053, MGI:1916447
References
more
  • Summaries
    All 79
    Developmental Gene Expression 18
    Gene Ontology 18
    Phenotypes 5
  • Earliest
    J:17982 Giebel LB, et al., Developmental regulation of a constitutively expressed mouse mRNA encoding a 72-kDa heat shock-like protein. Dev Biol. 1988 Jan;125(1):200-7
  • Latest
    J:233627 Salinas E, et al., Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. J Virol. 2016 Feb;90(3):1397-413

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory