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Hspa8 Gene Detail
Summary
  • Symbol
    Hspa8
  • Name
    heat shock protein 8
  • Synonyms
    2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73
  • Feature Type
    protein coding gene
  • IDs
    MGI:105384
    NCBI Gene: 15481
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr9:40712572-40716498 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 21.55 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    444 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105384
 protein coding gene Chr9:40712280-40721383 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034670
 protein coding gene Chr9:39039892-39040733 (+)
A/J MGP_AJ_G0034650
 protein coding gene Chr9:38039827-38041214 (+)
AKR/J MGP_AKRJ_G0034576
 protein coding gene Chr9:38753721-38763868 (+)
BALB/cJ MGP_BALBcJ_G0034641
 protein coding gene Chr9:37782395-37783236 (+)
C3H/HeJ MGP_C3HHeJ_G0034352
 protein coding gene Chr9:39276683-39277537 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035164
 protein coding gene Chr9:40278176-40287719 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024370
 protein coding gene Chr2:133599670-133602972 (+)
CAST/EiJ MGP_CASTEiJ_G0033675
 protein coding gene Chr9:38998853-39005106 (+)
CBA/J MGP_CBAJ_G0034325
 protein coding gene Chr9:41677645-41683382 (+)
DBA/2J MGP_DBA2J_G0034484
 protein coding gene Chr9:37974538-37975672 (+)
FVB/NJ MGP_FVBNJ_G0034424
 protein coding gene Chr9:37196852-37201187 (+)
LP/J MGP_LPJ_G0034565
 protein coding gene Chr9:39320049-39321267 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034468
 protein coding gene Chr9:43720519-43721360 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035183
 protein coding gene Chr9:38673281-38685978 (+)
PWK/PhJ MGP_PWKPhJ_G0033380
 protein coding gene Chr9:37781602-37782832 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033216
 protein coding gene Chr9:38906364-38910141 (+)
WSB/EiJ MGP_WSBEiJ_G0033788
 protein coding gene Chr9:38701356-38706018 (+)



Homology
more
  • Human Ortholog
    HSPA8, heat shock protein family A (Hsp70) member 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPA8, heat shock protein family A (Hsp70) member 8
  • Synonyms
    HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71
  • Links
    NCBI Gene ID: 3312
    UniProt: P11142

  • Chr Location
    11q24.1; chr11:123057489-123063230 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HSPA8 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    250
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    933
  • Tissues
    122
  • cDNA Data
    101
  • Literature Summary
    31
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15481 NCBI Gene Model | MGI Sequence Detail 3927 C57BL/6J ±  kb
transcript NM_031165 RefSeq | MGI Sequence Detail 2119 ZRU/MplStud  
polypeptide P63017 UniProt | EBI | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    19 Sequences
  • Protein Ontology
    PR:000008812 heat shock cognate 71 kDa protein
    (term hierarchy)
  • PDB
    3CQX
  • EC
    3.6.4.10
  • InterPro Domains
    IPR043129 ATPase, nucleotide binding domain
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
    IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
  • GlyGen
    P63017 6 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 117
    Genomic 8
    cDNA 103
    Primer pair 6

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-33053, MGI:1916447
References
more
  • Summaries
    All 129
    Developmental Gene Expression 31
    Gene Ontology 34
    Phenotypes 7
  • Earliest
    J:17982 Giebel LB, et al., Developmental regulation of a constitutively expressed mouse mRNA encoding a 72-kDa heat shock-like protein. Dev Biol. 1988 Jan;125(1):200-7
  • Latest
    J:367712 Yang G, et al., HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation. Cell Rep. 2025 Mar 25;44(3):115339
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory