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Hspa8 Gene Detail
Summary
  • Symbol
    Hspa8
  • Name
    heat shock protein 8
  • Synonyms
    2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73
  • Feature Type
    protein coding gene
  • IDs
    MGI:105384
    NCBI Gene: 15481
  • Gene Overview
    MyGene.info: HSPA8
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:40801276-40805202 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 21.55 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105384
 protein coding gene Chr9:40800984-40810087 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034670
 protein coding gene Chr9:39039892-39040733 (+)
A/J MGP_AJ_G0034650
 protein coding gene Chr9:38039827-38041214 (+)
AKR/J MGP_AKRJ_G0034576
 protein coding gene Chr9:38753721-38763868 (+)
BALB/cJ MGP_BALBcJ_G0034641
 protein coding gene Chr9:37782395-37783236 (+)
C3H/HeJ MGP_C3HHeJ_G0034352
 protein coding gene Chr9:39276683-39277537 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035164
 protein coding gene Chr9:40278176-40287719 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024370
 protein coding gene Chr2:133599670-133602972 (+)
CAST/EiJ MGP_CASTEiJ_G0033675
 protein coding gene Chr9:38998853-39005106 (+)
CBA/J MGP_CBAJ_G0034325
 protein coding gene Chr9:41677645-41683382 (+)
DBA/2J MGP_DBA2J_G0034484
 protein coding gene Chr9:37974538-37975672 (+)
FVB/NJ MGP_FVBNJ_G0034424
 protein coding gene Chr9:37196852-37201187 (+)
LP/J MGP_LPJ_G0034565
 protein coding gene Chr9:39320049-39321267 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034468
 protein coding gene Chr9:43720519-43721360 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035183
 protein coding gene Chr9:38673281-38685978 (+)
PWK/PhJ MGP_PWKPhJ_G0033380
 protein coding gene Chr9:37781602-37782832 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033216
 protein coding gene Chr9:38906364-38910141 (+)
WSB/EiJ MGP_WSBEiJ_G0033788
 protein coding gene Chr9:38701356-38706018 (+)



Homology
more
  • Human Ortholog
    HSPA8, heat shock protein family A (Hsp70) member 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSPA8, heat shock protein family A (Hsp70) member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP1, LAP-1, NIP71
  • Links
    NCBI Gene ID: 3312
    neXtProt AC: NX_P11142
    UniProt: P11142

  • Chr Location
    11q24.1; chr11:123057492-123062366 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    164
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    88
  • cDNA Data
    101
  • Literature Summary
    22
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15481 NCBI Gene Model | MGI Sequence Detail 3927 C57BL/6J ±  kb
transcript NM_031165 RefSeq | MGI Sequence Detail 2119 C57BL/6  
polypeptide P63017 UniProt | EBI | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    19 Sequences
  • Protein Ontology
    PR:000008812 heat shock cognate 71 kDa protein
    (term hierarchy)
  • PDB
    3CQX
  • InterPro Domains
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
    IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 114
    Genomic 7
    cDNA 103
    Primer pair 4

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-33053, MGI:1916447
References
more
  • Summaries
    All 101
    Developmental Gene Expression 22
    Gene Ontology 25
    Phenotypes 5
  • Earliest
    J:17982 Giebel LB, et al., Developmental regulation of a constitutively expressed mouse mRNA encoding a 72-kDa heat shock-like protein. Dev Biol. 1988 Jan;125(1):200-7
  • Latest
    J:263412 Yagi H, et al., Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70. PLoS One. 2017;12(2):e0172257
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/24/2020
MGI 6.15 		The Jackson Laboratory