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Hspa8 Gene Detail
Summary
  • Symbol
    Hspa8
  • Name
    heat shock protein 8
  • Synonyms
    2410008N15Rik, Hsc70, Hsc71, Hsc73, Hsp73
  • Feature Type
    protein coding gene
  • IDs
    MGI:105384
    NCBI Gene: 15481
  • Gene Overview
    MyGene.info: HSPA8
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr9:40800984-40805200 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      4217 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 21.55 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HSPA8, heat shock protein family A (Hsp70) member 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HSPA8, heat shock protein family A (Hsp70) member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP1, LAP-1, NIP71
  • Links
    NCBI Gene ID: 3312
    neXtProt AC: NX_P11142
    UniProt: P11142

  • Chr Location
    11q24.1; chr11:123057492-123062366 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    121
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    29
  • Tissues
    23
  • cDNA Data
    99
  • Literature Summary
    20
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030238 VEGA Gene Model | MGI Sequence Detail 4217 C57BL/6J ±  kb
transcript OTTMUST00000074856 VEGA | MGI Sequence Detail 2394 Not Applicable  
polypeptide OTTMUSP00000039133 VEGA | MGI Sequence Detail 646 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    56 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
  • UniProt
    19 Sequences
  • Protein Ontology
    PR:000008812 heat shock cognate 71 kDa protein
    (term hierarchy)
  • PDB
    3CQX
  • InterPro Domains
    IPR018181 Heat shock protein 70, conserved site
    IPR013126 Heat shock protein 70 family
    IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
    IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 110
    Genomic 7
    cDNA 101
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-33053, MGI:1916447
References
more
  • Summaries
    All 96
    Developmental Gene Expression 20
    Gene Ontology 19
    Phenotypes 5
  • Earliest
    J:17982 Giebel LB, et al., Developmental regulation of a constitutively expressed mouse mRNA encoding a 72-kDa heat shock-like protein. Dev Biol. 1988 Jan;125(1):200-7
  • Latest
    J:254206 Coyne AN, et al., Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS. Cell Rep. 2017 Oct 3;21(1):110-125
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
06/12/2018
MGI 6.12 		The Jackson Laboratory