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Il4ra Gene Detail
Summary
  • Symbol
    Il4ra
  • Name
    interleukin 4 receptor, alpha
  • Synonyms
    CD124, Il4r, IL-4 receptor alpha chain
  • Feature Type
    protein coding gene
  • IDs
    MGI:105367
    NCBI Gene: 16190
  • Gene Overview
    MyGene.info: IL4R
Location & Maps
more
  • Sequence Map
    Chr7:125552120-125579474 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27355 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 68.94 cM
  • Mapping Data
    17 experiments
Homology
more
  • Human Ortholog
    IL4R, interleukin 4 receptor
  • Vertebrate Orthologs
    7
  • Human Ortholog
    IL4R, interleukin 4 receptor
    Orthology source: HomoloGene
  • Synonyms
    CD124, IL4RA, IL-4RA
  • Links
    NCBI Gene ID: 3566
    neXtProt AC: NX_P24394

  • Chr Location
    16p12.1-p11.2; chr16:27313668-27364778 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Il4ra mouse models; 2 with human IL4R associations

Human Disease Mouse Models
       Asthma, Susceptibility to   OMIM: 600807 View 2 models
       Human Immunodeficiency Virus Type 1, Susceptibility to   OMIM: 609423
IgE Responsiveness, Atopic; IGER   OMIM: 147050
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotypes from 6 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    192 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit reduced T helper 2 cell response to N. brasiliensis infection. Homozygotes for a null allele also display severe susceptibility to S. mansoni infection, enhanced carcinogen-induced intestinal tumour initiation, and altered control of chronic Leishmania major infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058201 VEGA Gene Model | MGI Sequence Detail 27355 C57BL/6J ±  kb
transcript OTTMUST00000142909 VEGA | MGI Sequence Detail 5256 Not Applicable  
polypeptide OTTMUSP00000074523 VEGA | MGI Sequence Detail 810 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    340 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    9 Sequences
  • Protein Ontology
    PR:000001866 interleukin-4 receptor subunit alpha
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR015319 Interleukin-4 receptor alpha, N-terminal
    IPR003531 Short hematopoietin receptor, family 1, conserved site
Molecular
Reagents
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  • All nucleic 34
    Genomic 5
    cDNA 21
    Primer pair 7
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-11386, MGD-MRK-33035
References
more
  • Summaries
    All 264
    Developmental Gene Expression 9
    Diseases 3
    Gene Ontology 10
    Phenotypes 192
  • Earliest
    J:32360 Mosley B, et al., The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell. 1989 Oct 20;59(2):335-48
  • Latest
    J:230585 Van Overmeire E, et al., M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment. Cancer Res. 2016 Jan 1;76(1):35-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory