Il4ra
Gene Detail

Symbol Name ID

Il4ra interleukin 4 receptor, alpha MGI:105367

Synonyms

CD124, Il4r, IL-4 receptor alpha chain

Feature Type

protein coding gene

Genetic Map

Chromosome 7

68.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)

Sequence Map

Chr7:125552282-125579472 bp, + strand From Ensembl annotation of GRCm38   27191 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7784  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: interleukin-4 receptor
Gene Tree: Il4ra

Human homologs

Human Homolog		IL4R, interleukin 4 receptor
NCBI Gene ID		3566
neXtProt AC		NX_P24394
Human Synonyms		CD124, IL4RA, IL-4RA
Human Chr (Location)		16p12.1-p11.2; chr16:27325230-27376099 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human IL4R

Alleles and phenotypes

All alleles(11) : Targeted(11)
 

Nullizygous mice exhibit reduced T helper 2 cell response to N. brasiliensis infection. Homozygotes for a null allele also display severe susceptibility to S. mansoni infection, enhanced carcinogen-induced intestinal tumour initiation, and altered control of chronic Leishmania major infection.

 
Human Diseases Modeled Using Mouse Il4ra (1)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	defense response to protozoan, negative regulation of T-helper 1 cell differentiation, ...
Component	extracellular region, extracellular space, ...
Function	cytokine receptor activity, protein binding

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (51)    Tissues (24)    Images (18)
Theiler Stages: 4, 5, 13, 14, 17, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	24
RT-PCR	25

cDNA source data(21)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(5) cDNA(21) Primer pair(7) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000030748 (Evidence)
Entrez Gene	16190 (Evidence)
DFCI	TC1572408, TC1639650
DoTS	DT.101289265, DT.101355407, DT.101374224, DT.101374227, DT.99864559
Consensus CDS Project	CCDS40121.1
International Mouse Knockout Project Status	Il4ra

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030748	Ensembl Gene Model | MGI Sequence Detail	27191	C57BL/6J
transcript	ENSMUST00000033004	Ensembl | MGI Sequence Detail	5092	Not Applicable
polypeptide	ENSMUSP00000033004	Ensembl | MGI Sequence Detail	810	Not Applicable

All sequences(53) RefSeq(3) UniProt(6)

Polymorphisms

RFLP(3) : SNPs(144 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR015319	Interleukin-4 receptor alpha chain, N-terminal
InterPro	IPR003531	Short hematopoietin receptor, family 1, conserved site
Protein Ontology	PR:000001866	interleukin-4 receptor subunit alpha

References

(Earliest) J:32360 Mosley B, et al., The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell. 1989 Oct 20;59(2):335-48
(Latest) J:194750 Egawa M, et al., Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4. Immunity. 2013 Mar 21;38(3):570-80
All references(232)

Other accession IDs

MGD-MRK-11386, MGD-MRK-33035