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Il4ra
Gene Detail
Symbol

Name
ID
Il4ra
interleukin 4 receptor, alpha
MGI:105367
Synonyms
CD124, Il4r, IL-4 receptor alpha chain
Feature Type
protein coding gene
Genetic Map
Chromosome 7
68.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr7:125552282-125579472 bp, + strand
From Ensembl annotation of GRCm38

  27191 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7784  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: IL4R
Protein SuperFamily: interleukin-4 receptor
Gene Tree: Il4ra

Human
homologs
IL4R, interleukin 4 receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3566
neXtProt AC: NX_P24394

Human Synonyms: CD124, IL4RA, IL-4RA

Human Chr (Location): 16p12.1-p11.2; chr16:27313668-27364778 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human IL4R

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice exhibit reduced T helper 2 cell response to N. brasiliensis infection. Homozygotes for a null allele also display severe susceptibility to S. mansoni infection, enhanced carcinogen-induced intestinal tumour initiation, and altered control of chronic Leishmania major infection.
 
Human Diseases Modeled in Mice Using Il4ra (1)    Mutations Annotated to Human Diseases (3)   
Interactions
Il4ra interacts with 271 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process defense response to protozoan, immune system process, ...
Component extracellular region, extracellular space, ...
Function cytokine receptor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (49)    Tissues (24)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 24
RT-PCR 23
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN il4r.1    NEW 
Molecular
reagents
All nucleic(34) Genomic(5) cDNA(21) Primer pair(7) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000030748 (Evidence)
Entrez Gene 16190 (Evidence)
DFCI TC1639650, TC1572408
DoTS DT.101289265, DT.101374227, DT.101374224, DT.101355407, DT.99864559
Consensus CDS Project CCDS40121.1
International Mouse Phenotyping Consortium Status Il4ra
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030748 Ensembl Gene Model | MGI Sequence Detail 27191 C57BL/6J ±  kb
transcript ENSMUST00000033004 Ensembl | MGI Sequence Detail 5092 Not Applicable 
polypeptide ENSMUSP00000033004 Ensembl | MGI Sequence Detail 810 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(5) UniProt(7)
Polymorphisms
RFLP(3) : SNPs within 2kb(336 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015319 Interleukin-4 receptor alpha chain, N-terminal
InterPro IPR003531 Short hematopoietin receptor, family 1, conserved site
Protein Ontology PR:000001866 interleukin-4 receptor subunit alpha
References
(Earliest) J:32360 Mosley B, et al., The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell. 1989 Oct 20;59(2):335-48
(Latest) J:220802 Orian JM, et al., Deletion of IL-4Ralpha in the BALB/c mouse is associated with altered lesion topography and susceptibility to experimental autoimmune encephalomyelitis. Autoimmunity. 2014 Nov 27;:1-14
All references(254)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11386, MGD-MRK-33035

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory