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Hes5
Gene Detail
Symbol

Name
ID
Hes5
hairy and enhancer of split 5 (Drosophila)
MGI:104876
Synonyms
bHLHb38
Feature Type
protein coding gene
Genetic Map
Chromosome 4
86.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:154960923-154962371 bp, + strand
From VEGA annotation of GRCm38

  1449 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 5 zebrafish

Gene Tree: Hes5

Human
homologs
Human Homolog HES5, hes family bHLH transcription factor 5
NCBI Gene ID 388585
neXtProt AC  NX_Q5TA89
Human Synonyms  bHLHb38
Human Chr (Location)  1p36.32; chr1:2528745-2530245 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Genomic Mutations involving Hes5 (2)
 
Mice homozygous for disruptions in this gene are phenotypically normal although there are subtile histological abnormalities associated with sensory organs.
 
Interactions
Hes5 interacts with 79 markers (Mir10a, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (72 annotations)
Process astrocyte differentiation, auditory receptor cell differentiation, ...
Component nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (223 records)
Data Summary: Results (447)    Tissues (212)    Images (141)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 421
Northern blot 6
RT-PCR 17
cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(31) Primer pair(6) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010459 (Evidence)
Ensembl Gene ModelENSMUSG00000048001 (Evidence)
Entrez Gene15208 (Evidence)
UniGene137268
DFCITC1582177
DoTSDT.97387998, DT.110838032
NIA Mouse Gene IndexU005192
Consensus CDS ProjectCCDS19018.1
International Mouse Knockout Project StatusHes5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010459 VEGA Gene Model | MGI Sequence Detail 1449 C57BL/6J ±  kb
transcript OTTMUST00000024351 VEGA | MGI Sequence Detail 1273 Not Applicable 
polypeptide OTTMUSP00000011204 VEGA | MGI Sequence Detail 167 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR003650 Orange
InterPro IPR018352 Orange subgroup
Protein Ontology PR:000008519 transcription factor HES-5
References
(Earliest) J:71335 Akazawa C, et al., Molecular characterization of a rat negative regulator with a basic helix-loop-helix structure predominantly expressed in the developing nervous system. J Biol Chem. 1992 Oct 25;267(30):21879-85
(Latest) J:214082 Maurer KA, et al., Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina. Development. 2014 Aug;141(16):3243-54
All references(277)
Other
accession IDs
MGD-MRK-28176

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory