Hes5
Gene Detail

Symbol Name ID

Hes5 hairy and enhancer of split 5 (Drosophila) MGI:104876

Synonyms

bHLHb38

Feature Type

protein coding gene

Genetic Map

Chromosome 4

86.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:154960923-154962371 bp, + strand From VEGA annotation of GRCm38   1449 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Hes5

Human homologs

Human Homolog		HES5, hairy and enhancer of split 5 (Drosophila)
NCBI Gene ID		388585
neXtProt AC		NX_Q5TA89
Human Synonyms		bHLHb38
Human Chr (Location)		1p36.32; chr1:2460184-2461684 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for disruptions in this gene are phenotypically normal although there are subtile histological abnormalities associated with sensory organs.

 

Gene Ontology (GO) classifications

All GO classifications: (71 annotations)

Process	astrocyte differentiation, auditory receptor cell differentiation, ...
Component	nucleus
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (201 records)
Data Summary: Results (431)    Tissues (194)    Images (126)
Theiler Stages: 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	405
Northern blot	6
RT-PCR	17

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(42) cDNA(28) Primer pair(6) Other(8)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000010459 (Evidence)
Ensembl Gene Model	ENSMUSG00000048001 (Evidence)
Entrez Gene	15208 (Evidence)
UniGene	137268
DFCI	TC1582177
DoTS	DT.110838032, DT.97387998
NIA Mouse Gene Index	U005192
Consensus CDS Project	CCDS19018.1
International Mouse Knockout Project Status	Hes5

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010459	VEGA Gene Model | MGI Sequence Detail	1449	C57BL/6J
transcript	OTTMUST00000024351	VEGA | MGI Sequence Detail	1273	Not Applicable
polypeptide	OTTMUSP00000011204	VEGA | MGI Sequence Detail	167	Not Applicable

All sequences(30) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
InterPro	IPR003650	Orange
InterPro	IPR018352	Orange subgroup
Protein Ontology	PR:000008519	transcription factor HES-5

References

(Earliest) J:20474 Sakagami T, et al., Structure and chromosomal locus of the mouse gene encoding a cerebellar Purkinje cell-specific helix-loop-helix factor Hes-3. Biochem Biophys Res Commun. 1994 Aug 30;203(1):594-601
(Latest) J:194596 Guiu J, et al., Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. J Exp Med. 2013 Jan 14;210(1):71-84
All references(250)

Other accession IDs

MGD-MRK-28176