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Ephb3 Gene Detail
Summary
  • Symbol
    Ephb3
  • Name
    Eph receptor B3
  • Synonyms
    Cek10, Etk2, HEK2, MDK5, Sek4, Tyro6
  • Feature Type
    protein coding gene
  • IDs
    MGI:104770
    NCBI Gene: 13845
  • Gene Overview
    MyGene.info: EPHB3
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:21204795-21223309 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 12.62 cM, cytoband B1-B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    55 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104770
protein coding gene Chr16:21204755-21223309 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022658
protein coding gene Chr16:18621141-18639681 (+)
A/J MGP_AJ_G0022620
protein coding gene Chr16:17730004-17748550 (+)
AKR/J MGP_AKRJ_G0022595
protein coding gene Chr16:18473545-18492103 (+)
BALB/cJ MGP_BALBcJ_G0022624
protein coding gene Chr16:17908932-17927472 (+)
C3H/HeJ MGP_C3HHeJ_G0022389
protein coding gene Chr16:18583825-18602444 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023075
protein coding gene Chr16:18990621-19009171 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020593
protein coding gene Chr16:18437039-18455629 (+)
CAST/EiJ MGP_CASTEiJ_G0021919
protein coding gene Chr16:18555728-18577738 (+)
CBA/J MGP_CBAJ_G0022361
protein coding gene Chr16:19816947-19835505 (+)
DBA/2J MGP_DBA2J_G0022493
protein coding gene Chr16:17718852-17738450 (+)
FVB/NJ MGP_FVBNJ_G0022468
protein coding gene Chr16:17690208-17708714 (+)
LP/J MGP_LPJ_G0022560
protein coding gene Chr16:18365231-18383786 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022488
protein coding gene Chr16:19423889-19442431 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023086
protein coding gene Chr16:18406382-18424930 (+)
PWK/PhJ MGP_PWKPhJ_G0021659
protein coding gene Chr16:17927460-17946806 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021489
protein coding gene Chr16:18198312-18216833 (+)
WSB/EiJ MGP_WSBEiJ_G0021962
protein coding gene Chr16:18373082-18391678 (+)



Homology
more
  • Human Ortholog
    EPHB3, EPH receptor B3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EPHB3, EPH receptor B3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EK2, ETK2, HEK2, TYRO6
  • Links
    NCBI Gene ID: 2049
    neXtProt AC: NX_P54753
    UniProt: P54753

  • Chr Location
    3q27.1; chr3:184561799-184582408 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    30 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit defects in corpus callosum formation and impaired Paneth cell downward migration in the intestinal epithelium, resulting in scattered positioning along crypt and villus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13845 NCBI Gene Model | MGI Sequence Detail 18515 C57BL/6J ±  kb
transcript NM_010143 RefSeq | MGI Sequence Detail 4164 C57BL/6  
polypeptide P54754 UniProt | EBI | MGI Sequence Detail 993 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000007131 ephrin type-B receptor 3
  • EC
  • InterPro Domains
    IPR001090 Ephrin receptor ligand binding domain
    IPR027936 Ephrin receptor, transmembrane domain
    IPR016257 Ephrin receptor type-A /type-B
    IPR034245 Ephrin type-B receptor 3, ligand binding domain
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR008979 Galactose-binding-like domain superfamily
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain superfamily
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Molecular
Reagents
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  • All nucleic 68
    cDNA 62
    Primer pair 4
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-28061, MGI:2146639
References
more
  • Summaries
    All 138
    Developmental Gene Expression 67
    Gene Ontology 15
    Phenotypes 52
  • Earliest
    J:19646 Becker N, et al., Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech Dev. 1994 Jul;47(1):3-17
  • Latest
    J:243634 Laussu J, et al., Eph/Ephrin Signaling Controls Progenitor Identities In The Ventral Spinal Cord. Neural Dev. 2017 Jun 08;12(1):10

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory