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Gene Detail
Eph receptor B3
Synonyms Cek10, Etk2, HEK2, MDK5, Sek4, Tyro6
Feature Type protein coding gene
Genetic Map
Chromosome 16
12.62 cM, cytoband B1-B4
Detailed Genetic Map ± 1 cM

Mapping data(2)
Sequence Map
Chr16:21204755-21223305 bp, + strand
From VEGA annotation of GRCm38

  18551 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:20938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Ephb3

Human Homolog EPHB3, EPH receptor B3
NCBI Gene ID 2049
neXtProt AC  NX_P54753
Human Synonyms  ETK2, HEK2, TYRO6
Human Chr (Location)  3q27.1; chr3:184561799-184582408 (+)  GRCh38
alleles, and
All mutations/alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
Homozygotes for a targeted null mutation exhibit defects in corpus callosum formation and impaired Paneth cell downward migration in the intestinal epithelium, resulting in scattered positioning along crypt and villus.
Ephb3 interacts with 382 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
All GO classifications: (51 annotations)
Process angiogenesis, axonal fasciculation, ...
Component cell projection, integral component of membrane, ...
Function ATP binding, axon guidance receptor activity, ...
External Resources: FuncBase
Literature Summary: (56 records)
Data Summary: Results (166)    Tissues (110)    Images (61)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 141
Northern blot 8
cDNA source data(58)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(66) cDNA(60) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
VEGA Gene ModelOTTMUSG00000035120 (Evidence)
Ensembl Gene ModelENSMUSG00000005958 (Evidence)
Entrez Gene13845 (Evidence)
DFCITC1581257, TC1702516
DoTSDT.101150308, DT.101733443, DT.40170320
NIA Mouse Gene IndexU016937
Consensus CDS ProjectCCDS28060.1
International Mouse Knockout Project StatusEphb3
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035120 VEGA Gene Model | MGI Sequence Detail 18551 C57BL/6J ±  kb
transcript OTTMUST00000089377 VEGA | MGI Sequence Detail 4185 Not Applicable 
polypeptide OTTMUSP00000048842 VEGA | MGI Sequence Detail 993 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(55 from dbSNP Build 137)
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007131 ephrin type-B receptor 3
References (Earliest) J:19646 Becker N, et al., Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech Dev. 1994 Jul;47(1):3-17
(Latest) J:203654 Srivastava N, et al., EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak. Mol Cell Neurosci. 2013 Jan;52:106-16
All references(122)
accession IDs
MGD-MRK-28061, MGI:2146639

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory