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Ephb3
Gene Detail
Symbol

Name
ID
Ephb3
Eph receptor B3
MGI:104770
Synonyms
Cek10, Etk2, HEK2, MDK5, Sek4, Tyro6
Feature Type
protein coding gene
Genetic Map
Chromosome 16
12.62 cM, cytoband B1-B4
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:21204755-21223305 bp, + strand
From VEGA annotation of GRCm38

  18551 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EPHB3
Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Ephb3

Human
homologs
EPHB3, EPH receptor B3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2049
neXtProt AC: NX_P54753

Human Synonyms: ETK2, HEK2, TYRO6

Human Chr (Location): 3q27.1; chr3:184561799-184582408 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(8) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit defects in corpus callosum formation and impaired Paneth cell downward migration in the intestinal epithelium, resulting in scattered positioning along crypt and villus.
 
Interactions
Ephb3 interacts with 381 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (50 annotations)
Process angiogenesis, axonal fasciculation, ...
Component cell projection, integral component of membrane, ...
Function ATP binding, axon guidance receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (59 records)
Data Summary: Results (166)    Tissues (110)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 141
Northern blot 8
RT-PCR 17
cDNA source data(58)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA EPHB3 ; Xenbase LOC100489199 ; ZFIN ephb3a    NEW 
Molecular
reagents
All nucleic(66) cDNA(60) Primer pair(4) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035120 (Evidence)
Ensembl Gene Model ENSMUSG00000005958 (Evidence)
Entrez Gene 13845 (Evidence)
UniGene 6972
DFCI TC1702516, TC1581257
DoTS DT.40170320, DT.101733443, DT.101150308
NIA Mouse Gene Index U016937
EC 2.7.10.1
Consensus CDS Project CCDS28060.1
International Mouse Phenotyping Consortium Status Ephb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035120 VEGA Gene Model | MGI Sequence Detail 18551 C57BL/6J ±  kb
transcript OTTMUST00000089377 VEGA | MGI Sequence Detail 4185 Not Applicable 
polypeptide OTTMUSP00000048842 VEGA | MGI Sequence Detail 993 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(55 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007131 ephrin type-B receptor 3
References
(Earliest) J:19646 Becker N, et al., Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech Dev. 1994 Jul;47(1):3-17
(Latest) J:212428 Raft S, et al., Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear. Dev Biol. 2014 Jun 1;390(1):51-67
All references(124)
Other
accession IDs
MGD-MRK-28061, MGI:2146639

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory