Ephb3
Gene Detail

Symbol Name ID

Ephb3 Eph receptor B3 MGI:104770

Synonyms

Cek10, Etk2, HEK2, MDK5, Sek4, Tyro6

Feature Type

protein coding gene

Genetic Map

Chromosome 16

12.62 cM, cytoband B1-B4
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:21204755-21223305 bp, + strand From VEGA annotation of GRCm38   18551 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Ephb3

Human homologs

Human Homolog		EPHB3, EPH receptor B3
NCBI Gene ID		2049
neXtProt AC		NX_P54753
Human Synonyms		ETK2, HEK2, TYRO6
Human Chr (Location)		3q21-qter; chr3:184279587-184300196 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(4) Gene trapped(8)
 

Homozygotes for a targeted null mutation exhibit defects in corpus callosum formation and impaired Paneth cell downward migration in the intestinal epithelium, resulting in scattered positioning along crypt and villus.

 

Gene Ontology (GO) classifications

All GO classifications: (50 annotations)

Process	angiogenesis, axonal fasciculation, ...
Component	cell projection, integral to membrane, ...
Function	ATP binding, axon guidance receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (57 records)
Data Summary: Results (163)    Tissues (107)    Images (58)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	138
Northern blot	8
RT-PCR	17

cDNA source data(58)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(65) cDNA(60) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035120 (Evidence)
Ensembl Gene Model	ENSMUSG00000005958 (Evidence)
Entrez Gene	13845 (Evidence)
UniGene	6972
DFCI	TC1581257, TC1702516
DoTS	DT.101150308, DT.101733443, DT.40170320
NIA Mouse Gene Index	U016937
EC	2.7.10.1
Consensus CDS Project	CCDS28060.1
International Mouse Knockout Project Status	Ephb3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035120	VEGA Gene Model | MGI Sequence Detail	18551	C57BL/6J
transcript	OTTMUST00000089377	VEGA | MGI Sequence Detail	4185	Not Applicable
polypeptide	OTTMUSP00000048842	VEGA | MGI Sequence Detail	993	Not Applicable

All sequences(36) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001090	Ephrin receptor ligand binding domain
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR021129	Sterile alpha motif, type 1
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016257	Tyrosine-protein kinase, ephrin receptor
InterPro	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
InterPro	IPR001426	Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology	PR:000007131	ephrin type-B receptor 3

References

(Earliest) J:19646 Becker N, et al., Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech Dev. 1994 Jul;47(1):3-17
(Latest) J:194441 Barthet G, et al., Presenilin mediates neuroprotective functions of ephrinB and brain-derived neurotrophic factor and regulates ligand-induced internalization and metabolism of EphB2 and TrkB receptors. Neurobiol Aging. 2013 Feb;34(2):499-510
All references(120)

Other accession IDs

MGD-MRK-28061, MGI:2146639