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Rora Gene Detail
Summary
  • Symbol
    Rora
  • Name
    RAR-related orphan receptor alpha
  • Synonyms
    9530021D13Rik, Nr1f1, tmgc26
  • Feature Type
    protein coding gene
  • IDs
    MGI:104661
    NCBI Gene: 19883
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:68653786-69388246 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 37.45 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5530 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104661
protein coding gene Chr9:68653407-69388246 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034990
protein coding gene Chr9:68595201-69379315 (+)
A/J MGP_AJ_G0034970
protein coding gene Chr9:66249690-66995388 (+)
AKR/J MGP_AKRJ_G0034900
protein coding gene Chr9:67823909-68582738 (+)
BALB/cJ MGP_BALBcJ_G0034963
protein coding gene Chr9:65979406-66723424 (+)
C3H/HeJ MGP_C3HHeJ_G0034672
protein coding gene Chr9:68323731-69091180 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035482
protein coding gene Chr9:70459613-71234723 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032393
protein coding gene Chr9:65831158-66564788 (+)
CAST/EiJ MGP_CASTEiJ_G0033994
protein coding gene Chr9:68571843-69340363 (+)
CBA/J MGP_CBAJ_G0034644
protein coding gene Chr9:72921221-73738132 (+)
DBA/2J MGP_DBA2J_G0034803
protein coding gene Chr9:66009842-66750277 (+)
FVB/NJ MGP_FVBNJ_G0034745
protein coding gene Chr9:65314946-66065714 (+)
LP/J MGP_LPJ_G0034885
protein coding gene Chr9:68869348-69643360 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034787
protein coding gene Chr9:74068467-74851367 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035504
protein coding gene Chr9:67953791-68721493 (+)
PWK/PhJ MGP_PWKPhJ_G0033698
protein coding gene Chr9:66204344-66962075 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033531
protein coding gene Chr9:68237637-69018505 (+)
WSB/EiJ MGP_WSBEiJ_G0034106
protein coding gene Chr9:67845286-68613330 (+)



Homology
more
  • Human Ortholog
    RORA, RAR related orphan receptor A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RORA, RAR related orphan receptor A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IDDECA, NR1F1, ROR1, ROR2, ROR3, RZRA, RZR-ALPHA
  • Links
    NCBI Gene ID: 6095
    neXtProt AC: NX_P35398
    UniProt: P35398

  • Chr Location
    15q22.2; chr15:60488284-61229303 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    104 phenotypes from 6 alleles in 9 genetic backgrounds
    174 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for null mutations exhibit ataxia, cerebellar dysgenesis, impaired Purkinje and granule cell development, olfactory defects, hypoalphalipoproteinemia, and death around 4 weeks. Heterozygotes show slow Purkinje cell dedritic atrophy and loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032238 Ensembl Gene Model | MGI Sequence Detail 734461 C57BL/6J ±  kb
    transcript ENSMUST00000034766 Ensembl | MGI Sequence Detail 10878 Not Applicable  
    polypeptide ENSMUSP00000034766 Ensembl | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 11
      cDNA 30
      Primer pair 4
      Other 3

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-14383, MGD-MRK-26101, MGI:2442931, MGI:2670426, MGI:3054678
    References
    more
    • Summaries
      All 299
      Developmental Gene Expression 56
      Gene Ontology 28
      Phenotypes 174
    • Earliest
      J:13140 SIDMAN RL, et al., Staggerer, a new mutation in the mouse affecting the cerebellum. Science. 1962 Aug 24;137:610-2
    • Latest
      J:266449 Rafei-Shamsabadi DA, et al., Lack of Type 2 Innate Lymphoid Cells Promotes a Type I-Driven Enhanced Immune Response in Contact Hypersensitivity. J Invest Dermatol. 2018 Sep;138(9):1962-1972

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory