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Rora Gene Detail
Summary
  • Symbol
    Rora
  • Name
    RAR-related orphan receptor alpha
  • Synonyms
    9530021D13Rik, Nr1f1, tmgc26
  • Feature Type
    protein coding gene
  • IDs
    MGI:104661
    NCBI Gene: 19883
Location & Maps
more
  • Sequence Map
    Chr9:68653786-69388246 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      734461 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RORA, RAR related orphan receptor A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RORA, RAR related orphan receptor A
    Orthology source: HomoloGene
  • Synonyms
    NR1F1, ROR1, ROR2, ROR3, RZRA, RZR-ALPHA
  • Links
    NCBI Gene ID: 6095
    neXtProt AC: NX_P35398

  • Chr Location
    15q22.2; chr15:60488284-61229303 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    102 phenotypes from 6 alleles in 9 genetic backgrounds
    160 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Rora
  • Incidental Mutations
Homozygotes for null mutations exhibit ataxia, cerebellar dysgenesis, impaired Purkinje and granule cell development, olfactory defects, hypoalphalipoproteinemia, and death around 4 weeks. Heterozygotes show slow Purkinje cell dedritic atrophy and loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023055 VEGA Gene Model | MGI Sequence Detail 734461 C57BL/6J ±  kb
transcript OTTMUST00000055460 VEGA | MGI Sequence Detail 10878 Not Applicable  
polypeptide OTTMUSP00000026559 VEGA | MGI Sequence Detail 523 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5530 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR003079 Nuclear receptor ROR
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
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  • All nucleic 47
    Genomic 11
    cDNA 29
    Primer pair 4
    Other 3

    Microarray probesets 11
Other
Accession IDs
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MGD-MRK-14383, MGD-MRK-26101, MGI:2442931, MGI:2670426, MGI:3054678
References
more
  • Summaries
    All 258
    Developmental Gene Expression 48
    Gene Ontology 26
    Phenotypes 160
  • Earliest
    J:13140 SIDMAN RL, et al., Staggerer, a new mutation in the mouse affecting the cerebellum. Science. 1962 Aug 24;137:610-2
  • Latest
    J:227021 Mallika C, et al., Gbx2 is essential for maintaining thalamic neuron identity and repressing habenular characters in the developing thalamus. Dev Biol. 2015 Nov 1;407(1):26-39

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory