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Rora
Gene Detail
Symbol

Name
ID
Rora
RAR-related orphan receptor alpha
MGI:104661
Synonyms
9530021D13Rik, Nr1f1, tmgc26
Feature Type
protein coding gene
Genetic Map
Chromosome 9
37.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr9:68653786-69388246 bp, + strand
From VEGA annotation of GRCm38

  734461 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56594  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: RORA
Gene Tree: Rora

Human
homologs
RORA, RAR-related orphan receptor A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6095
neXtProt AC: NX_P35398

Human Synonyms: NR1F1, ROR1, ROR2, ROR3, RZRA, RZR-ALPHA

Human Chr (Location): 15q22.2; chr15:60488284-61229303 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Chemically induced (ENU)(2) Gene trapped(3) Spontaneous(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for null mutations exhibit ataxia, cerebellar dysgenesis, impaired Purkinje and granule cell development, olfactory defects, hypoalphalipoproteinemia, and death around 4 weeks. Heterozygotes show slow Purkinje cell dedritic atrophy and loss.
 
Interactions
Rora interacts with 587 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process angiogenesis, cellular response to hypoxia, ...
Component nucleus
Function beta-catenin binding, core promoter sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (46 records)
Data Summary: Results (521)    Tissues (301)    Images (89)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 452
Northern blot 11
RT-PCR 55
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rora ; ZFIN roraa, rorab    NEW 
Molecular
reagents
All nucleic(48) Genomic(11) cDNA(31) Primer pair(4) Other(2)
Microarray probesets(11)
Other database
links
VEGA Gene Model OTTMUSG00000023055 (Evidence)
Ensembl Gene Model ENSMUSG00000032238 (Evidence)
Entrez Gene 19883 (Evidence)
DFCI TC1577083, TC1586960, TC1592080, TC1681027, TC1693028, TC1728754
DoTS DT.40134876, DT.486288, DT.87039215, DT.99850366
NIA Mouse Gene Index U043000, U094151
Consensus CDS Project CCDS23314.1, CCDS72268.1
International Mouse Phenotyping Consortium Status Rora
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023055 VEGA Gene Model | MGI Sequence Detail 734461 C57BL/6J ±  kb
transcript OTTMUST00000055460 VEGA | MGI Sequence Detail 10878 Not Applicable 
polypeptide OTTMUSP00000026559 VEGA | MGI Sequence Detail 523 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(16) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(5595 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001723 Nuclear hormone receptor
InterPro IPR000536 Nuclear hormone receptor, ligand-binding domain
InterPro IPR003079 Nuclear receptor ROR
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000014163 nuclear receptor ROR-alpha
References
(Earliest) J:13140 SIDMAN RL, et al., Staggerer, a new mutation in the mouse affecting the cerebellum. Science. 1962 Aug 24;137:610-2
(Latest) J:219791 Bourane S, et al., Identification of a spinal circuit for light touch and fine motor control. Cell. 2015 Jan 29;160(3):503-15
All references(251)
Other
accession IDs
MGD-MRK-14383, MGD-MRK-26101, MGI:2442931, MGI:2670426, MGI:3054678

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory