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Rora Gene Detail
Summary
  • Symbol
    Rora
  • Name
    RAR-related orphan receptor alpha
  • Synonyms
    9530021D13Rik, Nr1f1, tmgc26
  • Feature Type
    protein coding gene
  • IDs
    MGI:104661
    NCBI Gene: 19883
  • Alliance
    genome feature page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:68561068-69295528 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 37.45 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19062 from dbSNP Build 142
  • Strain Annotations
    31
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104661
 protein coding gene Chr9:68560627-69295528 (+)
129S1/SvImJ ENSMUSG00200041569
 protein coding gene Chr9:65644434-65655866 (+)
129S1/SvImJ ENSMUSGG00200054630
 protein coding gene Chr9:66285805-66384408 (+)
A/J ENSMUSGG00195055338
 protein coding gene Chr9:66064064-66162649 (+)
A/J ENSMUSG00195023846
 protein coding gene Chr9:65421289-65432757 (+)
AKR/J ENSMUSG00220036463
 protein coding gene Chr9:65568680-65580150 (+)
AKR/J ENSMUSGG00220054563
 protein coding gene Chr9:66208455-66307012 (+)
BALB/cJ ENSMUSGG00180055444
 protein coding gene Chr9:66183928-66282522 (+)
BALB/cJ ENSMUSG00180016629
 protein coding gene Chr9:65541079-65552564 (+)
C3H/HeJ ENSMUSG00175011730
 protein coding gene Chr9:65554660-65566139 (+)
C3H/HeJ ENSMUSGG00175054821
 protein coding gene Chr9:66197433-66296008 (+)
C57BL/6NJ ENSMUSGG00215055799
 protein coding gene Chr9:66140363-66238924 (+)
C57BL/6NJ ENSMUSG00215019497
 protein coding gene Chr9:65503656-65515117 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032393
 protein coding gene Chr9:65831158-66564788 (+)
CAST/EiJ ENSTCUGG00005054026
 protein coding gene Chr9:66009580-66107793 (+)
CBA/J ENSMUSG00210013605
 protein coding gene Chr9:65635425-65646908 (+)
CBA/J ENSMUSGG00210055002
 protein coding gene Chr9:66278195-66376767 (+)
DBA/2J ENSMUSG00185033996
 protein coding gene Chr9:65659143-65670624 (+)
DBA/2J ENSMUSGG00185057620
 protein coding gene Chr9:66301904-66400482 (+)
FVB/NJ ENSMUSG00205026363
 protein coding gene Chr9:65933220-65944696 (+)
FVB/NJ ENSMUSGG00205054572
 protein coding gene Chr9:66576026-66674620 (+)
JF1/MsJ ENSUMUGG00000058301
 protein coding gene Chr9:66322828-66421109 (+)
LP/J ENSMUSGG00230055406
 protein coding gene Chr9:66480988-66579599 (+)
LP/J ENSMUSG00230024074
 protein coding gene Chr9:65837892-65849325 (+)
NOD/ShiLtJ ENSMUSGG00190054779
 protein coding gene Chr9:66405487-66504247 (+)
NOD/ShiLtJ ENSMUSG00190019603
 protein coding gene Chr9:65766913-65777126 (+)
NZO/HlLtJ ENSMUSGG00225055384
 protein coding gene Chr9:66602552-66700824 (+)
NZO/HlLtJ ENSMUSG00225044894
 protein coding gene Chr9:65958650-65970130 (+)
PWK/PhJ ENSLUMGG00010054088
 protein coding gene Chr9:66273646-66371542 (+)
SPRET/EiJ ENSMSPG00010017430
 protein coding gene Chr9:67362907-67453564 (+)
WSB/EiJ ENSIUOGG00005054126
 protein coding gene Chr9:65758720-65857272 (+)



Homology
more
  • Human Ortholog
    RORA, RAR related orphan receptor A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RORA, RAR related orphan receptor A
  • Synonyms
    IDDECA, NR1F1, ROR1, ROR2, ROR3, RORa1, RORalpha, RZRA, RZR-ALPHA
  • Links
    NCBI Gene ID: 6095
    UniProt: P35398

  • Chr Location
    15q22.2; chr15:60488284-61229302 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human RORA associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    109 phenotypes from 7 alleles in 10 genetic backgrounds
    264 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations exhibit ataxia, cerebellar dysgenesis, impaired Purkinje and granule cell development, olfactory defects, hypoalphalipoproteinemia, and death around 4 weeks. Heterozygotes show slow Purkinje cell dedritic atrophy and loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    112
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1485
  • Tissues
    413
  • cDNA Data
    29
  • Literature Summary
    83
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032238 Ensembl Gene Model | MGI Sequence Detail 734461 C57BL/6J ±  kb
    transcript ENSMUST00000034766 Ensembl | MGI Sequence Detail 10878 Not Applicable  
    polypeptide ENSMUSP00000034766 Ensembl | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 11
      cDNA 31
      Primer pair 10
      Other 10
      Antibodies 8

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-14383, MGD-MRK-26101, MGI:2442931, MGI:2670426, MGI:3054678
    References
    more
    • Summaries
      All 443
      Developmental Gene Expression 83
      Gene Ontology 30
      Phenotypes 264
    • Earliest
      J:13140 SIDMAN RL, et al., Staggerer, a new mutation in the mouse affecting the cerebellum. Science. 1962 Aug 24;137:610-2
    • Latest
      J:391198 Huang H, et al., Group 2 innate lymphoid cells activate myelin-reactive T cells to augment neuroinflammation. Immunity. 2026 Aug 6;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory