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Pemt
Gene Detail
Symbol

Name
ID
Pemt
phosphatidylethanolamine N-methyltransferase
MGI:104535
Synonyms
Pempt, Pempt2
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:59970614-60046489 bp, - strand
From VEGA annotation of GRCm38

  75876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:6291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PEMT
Protein SuperFamily: phosphatidylethanolamine N-methyltransferase/Methylene-fatty-acyl-phospholipid synthase
Gene Tree: Pemt

Human
homologs
PEMT, phosphatidylethanolamine N-methyltransferase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10400
neXtProt AC: NX_Q9UBM1

Human Synonyms: PEAMT, PEMPT, PEMT2, PNMT

Human Chr (Location): 17p11.2; chr17:17505563-17591703 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Genomic Mutations involving Pemt (3)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display a normal phenotype on normal diets but display liver abnormalities on choline deficient diets or high fat and cholesterol diets.
 
Mutations Annotated to Human Diseases (3)    Phenotype Images(3)
Interactions
Pemt interacts with 30 markers (Mir29b-2, Mir92-2, Mir124a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process glycerophospholipid metabolic process, lipid metabolic process, ...
Component brush border membrane, endoplasmic reticulum, ...
Function methyltransferase activity, N-methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (41)    Tissues (34)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 29
RT-PCR 12
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pemt ; ZFIN pemt    NEW 
Molecular
reagents
All nucleic(16) Genomic(5) cDNA(9) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000005808 (Evidence)
Ensembl Gene Model ENSMUSG00000000301 (Evidence)
Entrez Gene 18618 (Evidence)
DFCI TC1579102, TC1683627, TC1612611, TC1707109, TC1773327
DoTS DT.101349060, DT.91377646, DT.110508250, DT.103562417, DT.94316260, DT.99840372, DT.94346229, DT.94346226
NIA Mouse Gene Index U132382
EC 2.1.1.71, 2.1.1.17
Consensus CDS Project CCDS24782.1
International Mouse Phenotyping Consortium Status Pemt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005808 VEGA Gene Model | MGI Sequence Detail 75876 C57BL/6J ±  kb
transcript OTTMUST00000012858 VEGA | MGI Sequence Detail 961 Not Applicable 
polypeptide OTTMUSP00000005980 VEGA | MGI Sequence Detail 236 Not Applicable 

For the selected sequences
All sequences(81) RefSeq(12) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(1113 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024960 Phosphatidylethanolamine N-methyltransferase/Methylene-fatty-acyl-phospholipid synthase
InterPro IPR007318 Phospholipid methyltransferase
Protein Ontology PR:000012543 phosphatidylethanolamine N-methyltransferase
References
(Earliest) J:37266 Walkey CJ, et al., Characterization of the murine phosphatidylethanol amine N- methyltransferase-2 gene. J Lipid Res. 1996 NOV;37(11):2341-2350
(Latest) J:193879 Wu G, et al., Choline supplementation promotes hepatic insulin resistance in phosphatidylethanolamine N-methyltransferase-deficient mice via increased glucagon action. J Biol Chem. 2013 Jan 11;288(2):837-47
All references(61)
Other
accession IDs
MGD-MRK-25966

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory