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Xrcc5 Gene Detail
Summary
  • Symbol
    Xrcc5
  • Name
    X-ray repair complementing defective repair in Chinese hamster cells 5
  • Synonyms
    Ku80, Ku86
  • Feature Type
    protein coding gene
  • IDs
    MGI:104517
    NCBI Gene: 22596
  • Gene Overview
    MyGene.info: XRCC5
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:72307421-72394952 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 36.50 cM, cytoband E
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    939 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104517
protein coding gene Chr1:72307417-72394953 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016131
protein coding gene Chr1:72807745-72898397 (+)
A/J MGP_AJ_G0016114
protein coding gene Chr1:70204799-70292707 (+)
AKR/J MGP_AKRJ_G0016071
protein coding gene Chr1:72219484-72310144 (+)
BALB/cJ MGP_BALBcJ_G0016069
protein coding gene Chr1:70336060-70424361 (+)
C3H/HeJ MGP_C3HHeJ_G0015900
protein coding gene Chr1:72534309-72622643 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016522
protein coding gene Chr1:75627664-75719699 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014243
protein coding gene Chr1:65923403-66011158 (+)
CAST/EiJ MGP_CASTEiJ_G0015484
protein coding gene Chr1:71827185-71923349 (+)
CBA/J MGP_CBAJ_G0015873
protein coding gene Chr1:78092463-78190569 (+)
DBA/2J MGP_DBA2J_G0015974
protein coding gene Chr1:69605299-69693017 (+)
FVB/NJ MGP_FVBNJ_G0015977
protein coding gene Chr1:68782820-68870731 (+)
LP/J MGP_LPJ_G0016046
protein coding gene Chr1:73866622-73960642 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015997
protein coding gene Chr1:81590874-81683852 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016569
protein coding gene Chr1:72253400-72345263 (+)
PWK/PhJ MGP_PWKPhJ_G0015271
protein coding gene Chr1:69048421-69137210 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015050
protein coding gene Chr1:71626036-71717630 (+)
WSB/EiJ MGP_WSBEiJ_G0015546
protein coding gene Chr1:72070065-72163653 (+)



Homology
more
  • Human Ortholog
    XRCC5, X-ray repair cross complementing 5
  • Vertebrate Orthologs
    11
  • Human Ortholog
    XRCC5, X-ray repair cross complementing 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    KARP1, KARP-1, KU80, Ku86, KUB2, NFIV
  • Links
    NCBI Gene ID: 7520
    neXtProt AC: NX_P13010
    UniProt: P13010

  • Chr Location
    2q35; chr2:216109297-216206293 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    1 images
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutants are defective in DNA double-strand break repair and show impaired growth and severe combined immunodeficiency due to defective assembly of TCRs and immunoglobulins. Mutants die early with osteopenia, atrophic skin and hepatic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026187 Ensembl Gene Model | MGI Sequence Detail 87532 C57BL/6J ±  kb
    transcript ENSMUST00000027379 Ensembl | MGI Sequence Detail 2555 Not Applicable  
    polypeptide ENSMUSP00000027379 Ensembl | MGI Sequence Detail 732 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 95
      cDNA 94
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-25948, MGI:2138192
    References
    more
    • Summaries
      All 123
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 13
      Phenotypes 64
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:236776 Balmus G, et al., Synthetic lethality between PAXX and XLF in mammalian development. Genes Dev. 2016 Oct 1;30(19):2152-2157

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory