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Xrcc5
Gene Detail
Symbol

Name
ID
Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
MGI:104517
Synonyms
Ku80, Ku86
Feature Type
protein coding gene
Genetic Map
Chromosome 1
36.50 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:72307421-72394952 bp, + strand
From Ensembl annotation of GRCm38

  87532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: XRCC5
Protein SuperFamily: Ku DNA-binding complex, Ku80 subunit
Gene Tree: Xrcc5

Human
homologs
XRCC5, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7520
neXtProt AC: NX_P13010

Human Synonyms: KARP1, KARP-1, KU80, Ku86, KUB2, NFIV

Human Chr (Location): 2q35; chr2:216109297-216206293 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(44) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants are defective in DNA double-strand break repair and show impaired growth and severe combined immunodeficiency due to defective assembly of TCRs and immunoglobulins. Mutants die early with osteopenia, atrophic skin and hepatic abnormalities.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Xrcc5 interacts with 52 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (47 annotations)
Process cell proliferation, cellular hyperosmotic salinity response, ...
Component chromosome, cytoplasm, ...
Function 5'-deoxyribose-5-phosphate lyase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (1)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 5
cDNA source data(93)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase xrcc5 ; ZFIN xrcc5    NEW 
Molecular
reagents
All nucleic(94) cDNA(93) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000026187 (Evidence)
Entrez Gene 22596 (Evidence)
UniGene 246952
DFCI TC1614395, TC1574626, TC1779392
DoTS DT.91288582, DT.533787
NIA Mouse Gene Index U000424
EC 3.6.4.-
Consensus CDS Project CCDS35608.1
International Mouse Phenotyping Consortium Status Xrcc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026187 Ensembl Gene Model | MGI Sequence Detail 87532 C57BL/6J ±  kb
transcript ENSMUST00000027379 Ensembl | MGI Sequence Detail 2555 Not Applicable 
polypeptide ENSMUSP00000027379 Ensembl | MGI Sequence Detail 732 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(8) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(941 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006164 Ku70/Ku80 beta-barrel domain
InterPro IPR005160 Ku70/Ku80 C-terminal arm
InterPro IPR005161 Ku70/Ku80, N-terminal alpha/beta
InterPro IPR024193 Ku80
InterPro IPR014893 Ku, C-terminal
InterPro IPR016194 SPOC like C-terminal domain
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000017508 X-ray repair cross-complementing protein 5
References
(Earliest) J:15671 Porges AJ, et al., Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between species. J Immunol. 1990 Dec 15;145(12):4222-8
(Latest) J:220823 Jiang W, et al., Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining. Mol Cell. 2015 Apr 2;58(1):172-85
All references(109)
Other
accession IDs
MGD-MRK-25948, MGI:2138192

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory