Xrcc5
Gene Detail

Symbol Name ID

Xrcc5 X-ray repair complementing defective repair in Chinese hamster cells 5 MGI:104517

Synonyms

Ku80, Ku86

Feature Type

protein coding gene

Genetic Map

Chromosome 1

36.50 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:72307421-72394952 bp, + strand From Ensembl annotation of GRCm38   87532 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: Ku DNA-binding complex, Ku80 subunit
Gene Tree: Xrcc5

Human homologs

Human Homolog		XRCC5, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
NCBI Gene ID		7520
neXtProt AC		NX_P13010
Human Synonyms		KARP1, KARP-1, KU80, Ku86, KUB2, NFIV
Human Chr (Location)		2q35; chr2:216974020-217071016 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(46) : Targeted(2) Gene trapped(44)
 

Mutants are defective in DNA double-strand break repair and show impaired growth and severe combined immunodeficiency due to defective assembly of TCRs and immunoglobulins. Mutants die early with osteopenia, atrophic skin and hepatic abnormalities.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	cell proliferation, cellular hyperosmotic salinity response, ...
Component	chromosome, cytoplasm, ...
Function	5'-deoxyribose-5-phosphate lyase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (1)    Images (5)
Theiler Stages: 23

Assay Type	Results
RNA in situ	5

cDNA source data(92)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(93) cDNA(92) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000026187 (Evidence)
Entrez Gene	22596 (Evidence)
UniGene	246952
DFCI	TC1574626, TC1614395, TC1779392
DoTS	DT.533787, DT.91288582
NIA Mouse Gene Index	U000424
EC	3.6.4.-
Consensus CDS Project	CCDS35608.1
International Mouse Knockout Project Status	Xrcc5

Sequences

Length	Strain/Species
genomic	ENSMUSG00000026187	Ensembl Gene Model | MGI Sequence Detail	87532	C57BL/6J
transcript	ENSMUST00000027379	Ensembl | MGI Sequence Detail	2555	Not Applicable
polypeptide	ENSMUSP00000027379	Ensembl | MGI Sequence Detail	732	Not Applicable

All sequences(34) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(685 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024193	DNA helicase, ATP-dependent, Ku80 subunit
InterPro	IPR006164	DNA helicase, ATP-dependent, Ku type
InterPro	IPR005160	Ku70/Ku80 C-terminal arm
InterPro	IPR005161	Ku70/Ku80, N-terminal alpha/beta
InterPro	IPR014893	Ku, C-terminal
InterPro	IPR016194	Spen Paralogue and Orthologue SPOC, C-terminal-like
InterPro	IPR002035	von Willebrand factor, type A
Protein Ontology	PR:000017508	ATP-dependent DNA helicase 2 subunit 2

References

(Earliest) J:15671 Porges AJ, et al., Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between species. J Immunol. 1990 Dec 15;145(12):4222-8
(Latest) J:194527 Boon RA, et al., MicroRNA-34a regulates cardiac ageing and function. Nature. 2013 Mar 7;495(7439):107-10
All references(105)

Other accession IDs

MGD-MRK-25948, MGI:2138192