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Xrcc5
Gene Detail
 Symbol
Name
ID
Xrcc5
X-ray repair complementing defective repair in Chinese hamster cells 5
MGI:104517
Synonyms Ku80, Ku86
Feature Type protein coding gene
Genetic Map
Chromosome 1
36.50 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:72307421-72394952 bp, + strand
From Ensembl annotation of GRCm38

  87532 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40681  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: Ku DNA-binding complex, Ku80 subunit
Gene Tree: Xrcc5

Human
homologs
Human Homolog XRCC5, X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
NCBI Gene ID 7520
neXtProt AC  NX_P13010
Human Synonyms  KARP1, KARP-1, KU80, Ku86, KUB2, NFIV
Human Chr (Location)  2q35; chr2:216107658-216206293 (+)  GRCh38
Alleles
and
phenotypes
All alleles(46) : Targeted(2) Gene trapped(44)
 
Mutants are defective in DNA double-strand break repair and show impaired growth and severe combined immunodeficiency due to defective assembly of TCRs and immunoglobulins. Mutants die early with osteopenia, atrophic skin and hepatic abnormalities.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process cell proliferation, cellular hyperosmotic salinity response, ...
Component chromosome, cytoplasm, ...
Function 5'-deoxyribose-5-phosphate lyase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (1)    Images (5)
Theiler Stages: 23
Assay TypeResults
RNA in situ 5
cDNA source data(93)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(94) cDNA(93) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000026187 (Evidence)
Entrez Gene22596 (Evidence)
UniGene246952
DFCITC1574626, TC1614395, TC1779392
DoTSDT.533787, DT.91288582
NIA Mouse Gene IndexU000424
EC3.6.4.-
Consensus CDS ProjectCCDS35608.1
International Mouse Knockout Project StatusXrcc5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026187 Ensembl Gene Model | MGI Sequence Detail 87532 C57BL/6J ±  kb
transcript ENSMUST00000027379 Ensembl | MGI Sequence Detail 2555 Not Applicable 
polypeptide ENSMUSP00000027379 Ensembl | MGI Sequence Detail 732 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(8) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(941 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006164 Ku70/Ku80 beta-barrel domain
InterPro IPR005160 Ku70/Ku80 C-terminal arm
InterPro IPR005161 Ku70/Ku80, N-terminal alpha/beta
InterPro IPR024193 Ku80
InterPro IPR014893 Ku, C-terminal
InterPro IPR016194 SPOC like C-terminal domain
InterPro IPR002035 von Willebrand factor, type A
Protein Ontology PR:000017508 X-ray repair cross-complementing protein 5
References (Earliest) J:15671 Porges AJ, et al., Antigenic determinants of the Ku (p70/p80) autoantigen are poorly conserved between species. J Immunol. 1990 Dec 15;145(12):4222-8
(Latest) J:194527 Boon RA, et al., MicroRNA-34a regulates cardiac ageing and function. Nature. 2013 Mar 7;495(7439):107-10
All references(105)
Other
accession IDs
MGD-MRK-25948, MGI:2138192

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory