About   Help   FAQ
Clcn3 Gene Detail
Summary
  • Symbol
    Clcn3
  • Name
    chloride channel, voltage-sensitive 3
  • Synonyms
    Clc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:103555
    NCBI Gene: 12725
  • Gene Overview
    MyGene.info: CLCN3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:60910389-60983300 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 30.90 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    277 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103555
protein coding gene Chr8:60910389-60983311 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033632
protein coding gene Chr8:60792721-60866788 (-)
A/J MGP_AJ_G0033614
protein coding gene Chr8:58216011-58288696 (-)
AKR/J MGP_AKRJ_G0033539
protein coding gene Chr8:59884538-59959789 (-)
BALB/cJ MGP_BALBcJ_G0033610
protein coding gene Chr8:58465058-58537708 (-)
C3H/HeJ MGP_C3HHeJ_G0033320
protein coding gene Chr8:60551920-60625713 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034127
protein coding gene Chr8:63117431-63192892 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031075
protein coding gene Chr8:53465258-53539543 (-)
CAST/EiJ MGP_CASTEiJ_G0032645
protein coding gene Chr8:59970272-60051870 (-)
CBA/J MGP_CBAJ_G0033298
protein coding gene Chr8:65395423-65477415 (-)
DBA/2J MGP_DBA2J_G0033452
protein coding gene Chr8:57960869-58038343 (-)
FVB/NJ MGP_FVBNJ_G0033393
protein coding gene Chr8:57280177-57353417 (-)
LP/J MGP_LPJ_G0033540
protein coding gene Chr8:60762492-60841438 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033437
protein coding gene Chr8:67506183-67585328 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034145
protein coding gene Chr8:60133960-60206236 (-)
PWK/PhJ MGP_PWKPhJ_G0032354
protein coding gene Chr8:57272837-57347841 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032190
protein coding gene Chr8:59104086-59177208 (-)
WSB/EiJ MGP_WSBEiJ_G0032762
protein coding gene Chr8:60456893-60538857 (-)



Homology
more
  • Human Ortholog
    CLCN3, chloride voltage-gated channel 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CLCN3, chloride voltage-gated channel 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ClC-3, CLC3
  • Links
    NCBI Gene ID: 1182
    neXtProt AC: NX_P51790
    UniProt: P51790

  • Chr Location
    4q33; chr4:169620521-169723187 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Clcn3 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypes from 4 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mutations cause degeneration of hippocampal neurons and retinal photoreceptors, reduced body weight, behavioral deficits, gliosis, kyphosis and premature death, and may alter male fertility, ileum morphology, liver physiology, seizure susceptibility, and behavioral response to drugs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004319 Ensembl Gene Model | MGI Sequence Detail 72912 C57BL/6J ±  kb
    transcript ENSMUST00000004430 Ensembl | MGI Sequence Detail 4175 Not Applicable  
    polypeptide ENSMUSP00000004430 Ensembl | MGI Sequence Detail 866 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 25
      Primer pair 3

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-24439
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 10
      Phenotypes 32
    • Earliest
      J:24378 Mills KA, et al., Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80
    • Latest
      J:246528 Lu X, et al., ClC-3 chloride channel mediates the role of parathyroid hormone [1-34] on osteogenic differentiation of osteoblasts. PLoS One. 2017;12(4):e0176196

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory