About   Help   FAQ
Clcn3
Gene Detail
Symbol

Name
ID
Clcn3
chloride channel 3
MGI:103555
Synonyms
Clc3
Feature Type
protein coding gene
Genetic Map
Chromosome 8
30.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:60910389-60983300 bp, - strand
From VEGA annotation of GRCm38

  72912 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20435  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CLCN3
Protein SuperFamily: chloride channel protein
Gene Tree: Clcn3

Human
homologs
CLCN3, chloride channel, voltage-sensitive 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1182
neXtProt AC: NX_P51790

Human Synonyms: ClC-3, CLC3

Human Chr (Location): 4q33; chr4:169620521-169723187 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(119) : Gene trapped(114) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Nullizygous mutations cause degeneration of hippocampal neurons and retinal photoreceptors, reduced body weight, behavioral deficits, gliosis, kyphosis and premature death, and may alter male fertility, ileum morphology, liver physiology, seizure susceptibility, and behavioral response to drugs.
 
Human Diseases Modeled in Mice Using Clcn3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Clcn3 interacts with 348 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process adult locomotory behavior, chloride transmembrane transport, ...
Component apical plasma membrane, axon terminus, ...
Function antiporter activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (52)    Tissues (14)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 46
RT-PCR 6
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase clcn3    NEW 
Molecular
reagents
All nucleic(27) cDNA(24) Primer pair(3)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000022342 (Evidence)
Ensembl Gene Model ENSMUSG00000004319 (Evidence)
Entrez Gene 12725 (Evidence)
NIA Mouse Gene Index U029860
Consensus CDS Project CCDS22322.1, CCDS22323.1, CCDS52554.1, CCDS52555.1
International Mouse Phenotyping Consortium Status Clcn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022342 VEGA Gene Model | MGI Sequence Detail 72912 C57BL/6J ±  kb
transcript OTTMUST00000053283 VEGA | MGI Sequence Detail 4175 Not Applicable 
polypeptide OTTMUSP00000025334 VEGA | MGI Sequence Detail 866 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(23) UniProt(9)
Polymorphisms
PCR(2) : SNPs within 2kb(278 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000644 CBS domain
InterPro IPR002245 Chloride channel ClC-3
InterPro IPR014743 Chloride channel, core
InterPro IPR001807 Chloride channel, voltage gated
Protein Ontology PR:000005530 H(+)/Cl(-) exchange transporter 3
References
(Earliest) J:24378 Mills KA, et al., Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80
(Latest) J:219325 Zheng LY, et al., Deficiency of volume-regulated ClC-3 chloride channel attenuates cerebrovascular remodelling in DOCA-salt hypertension. Cardiovasc Res. 2013 Oct 1;100(1):134-42
All references(59)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-24439

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory