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Clcn3
Gene Detail
 Symbol
Name
ID
Clcn3
chloride channel 3
MGI:103555
Synonyms Clc3
Feature Type protein coding gene
Genetic Map
Chromosome 8
30.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:60910389-60983300 bp, - strand
From VEGA annotation of GRCm38

  72912 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20435  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: chloride channel protein
Gene Tree: Clcn3

Human
homologs
Human Homolog CLCN3, chloride channel, voltage-sensitive 3
NCBI Gene ID 1182
neXtProt AC  NX_P51790
Human Synonyms  ClC-3, CLC3
Human Chr (Location)  4q33; chr4:169620521-169723187 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(119) : Gene trapped(114) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mutations cause degeneration of hippocampal neurons and retinal photoreceptors, reduced body weight, behavioral deficits, gliosis, kyphosis and premature death, and may alter male fertility, ileum morphology, liver physiology, seizure susceptibility, and behavioral response to drugs.
 
Human Diseases Modeled Using Mouse Clcn3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Clcn3 interacts with 349 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process chloride transmembrane transport, chloride transport, ...
Component apical plasma membrane, cytoplasmic vesicle, ...
Function antiporter activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (52)    Tissues (12)    Images (19)
Theiler Stages: 23, 25, 28
Assay TypeResults
RNA in situ 46
RT-PCR 6
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(24) Primer pair(3)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000022342 (Evidence)
Ensembl Gene ModelENSMUSG00000004319 (Evidence)
Entrez Gene12725 (Evidence)
NIA Mouse Gene IndexU029860
Consensus CDS ProjectCCDS22322.1, CCDS22323.1, CCDS52554.1, CCDS52555.1
International Mouse Knockout Project StatusClcn3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022342 VEGA Gene Model | MGI Sequence Detail 72912 C57BL/6J ±  kb
transcript OTTMUST00000053283 VEGA | MGI Sequence Detail 4175 Not Applicable 
polypeptide OTTMUSP00000025334 VEGA | MGI Sequence Detail 866 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(23) UniProt(9)
Polymorphisms PCR(2) : SNPs within 2kb(278 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002245 Chloride channel ClC-3
InterPro IPR014743 Chloride channel, core
InterPro IPR001807 Chloride channel, voltage gated
InterPro IPR000644 Cystathionine beta-synthase, core
Protein Ontology PR:000005530 H(+)/Cl(-) exchange transporter 3
References (Earliest) J:24378 Mills KA, et al., Genetic mapping near the myd locus on mouse chromosome 8. Mamm Genome. 1995 Apr;6(4):278-80
(Latest) J:205976 Farmer LM, et al., CLC-3 chloride channels moderate long-term potentiation at Schaffer collateral-CA1 synapses. J Physiol. 2013 Feb 15;591(Pt 4):1001-15
All references(58)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-24439

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory