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Cacnb4
Gene Detail
Symbol

Name
ID
Cacnb4
calcium channel, voltage-dependent, beta 4 subunit
MGI:103301
Synonyms
3110038O15Rik, Cchb4
Feature Type
protein coding gene
Genetic Map
Chromosome 2
29.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr2:52428325-52676831 bp, - strand
From VEGA annotation of GRCm38

  248507 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20188  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cacnb4

Human
homologs
Human Homolog CACNB4, calcium channel, voltage-dependent, beta 4 subunit
NCBI Gene ID 785
neXtProt AC  NX_O00305
Human Synonyms  CAB4, CACNLB4, EA5, EIG9, EJM, EJM4, EJM6
Human Chr (Location)  2q22-q23; chr2:151832771-152099079 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human CACNB4
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Spontaneous(4) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants have lethargic behavior, unstable gait and seizures, with peripheral motor nerves showing reduced conduction velocity and prolonged distal latency.
 
Interactions
Cacnb4 interacts with 514 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (11 records)
Data Summary: Results (73)    Tissues (47)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 40
RT-PCR 14
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(17) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000012607 (Evidence)
Ensembl Gene ModelENSMUSG00000017412 (Evidence)
Entrez Gene12298 (Evidence)
PDB1VYV
Consensus CDS ProjectCCDS16034.1, CCDS16035.1, CCDS71052.1
International Mouse Knockout Project StatusCacnb4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012607 VEGA Gene Model | MGI Sequence Detail 248507 C57BL/6J ±  kb
transcript OTTMUST00000030067 VEGA | MGI Sequence Detail 8225 Not Applicable 
polypeptide OTTMUSP00000013519 VEGA | MGI Sequence Detail 519 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(14) UniProt(11)
Polymorphisms
RFLP(2) : SNPs within 2kb(1334 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
Protein Ontology PR:000004949 voltage-dependent L-type calcium channel subunit beta-4
References
(Earliest) J:28465 Dickie MM, Lethargic (lh). Mouse News Lett. 1964;30:31
(Latest) J:206966 Etemad S, et al., Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014 Jan 22;34(4):1446-61
All references(93)
Other
accession IDs
MGD-MRK-11801, MGD-MRK-24185, MGI:1920370

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory