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Acod1 Gene Detail
Summary
  • Symbol
    Acod1
  • Name
    aconitate decarboxylase 1
  • Synonyms
    Irg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103206
    NCBI Gene: 16365
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:103047012-103056573 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 51.67 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103206
protein coding gene Chr14:103046977-103056573 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021627
protein coding gene Chr14:99533734-99544184 (+)
A/J MGP_AJ_G0021585
protein coding gene Chr14:96245763-96255115 (+)
AKR/J MGP_AKRJ_G0021561
protein coding gene Chr14:99125842-99135059 (+)
BALB/cJ MGP_BALBcJ_G0021591
protein coding gene Chr14:96595665-96605449 (+)
C3H/HeJ MGP_C3HHeJ_G0021369
protein coding gene Chr14:99026985-99036368 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022031
protein coding gene Chr14:103547901-103558306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019571
protein coding gene Chr14:93118147-93128082 (+)
CAST/EiJ MGP_CASTEiJ_G0020886
protein coding gene Chr14:96361146-96371743 (+)
CBA/J MGP_CBAJ_G0021337
protein coding gene Chr14:107262526-107275866 (+)
DBA/2J MGP_DBA2J_G0021461
protein coding gene Chr14:95740637-95750790 (+)
FVB/NJ MGP_FVBNJ_G0021438
protein coding gene Chr14:94717225-94726551 (+)
LP/J MGP_LPJ_G0021529
protein coding gene Chr14:100351409-100360728 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021465
protein coding gene Chr14:110119065-110128514 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022054
protein coding gene Chr14:98635245-98645380 (+)
PWK/PhJ MGP_PWKPhJ_G0020629
protein coding gene Chr14:92735381-92745185 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020467
protein coding gene Chr14:94692895-94702183 (+)
WSB/EiJ MGP_WSBEiJ_G0020939
protein coding gene Chr14:99302422-99314838 (+)



Homology
more
  • Human Ortholog
    ACOD1, aconitate decarboxylase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ACOD1, aconitate decarboxylase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAD, IRG1
  • Links
    NCBI Gene ID: 730249
    neXtProt AC: NX_A6NK06
    UniProt: A6NK06

  • Chr Location
    13q22.3; chr13:76948559-76958642 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 35405
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ACOD1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
LPS-stimulated bone marrow macrophages derived from homozygous null mice fail to produce itaconate and exhibit significantly decreased succinate accumulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16365 NCBI Gene Model | MGI Sequence Detail 9562 C57BL/6J ±  kb
transcript NM_008392 RefSeq | MGI Sequence Detail 2588 C57BL/6  
polypeptide P54987 UniProt | EBI | MGI Sequence Detail 488 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-24074, MGI:2145617
References
more
  • Summaries
    All 44
    Gene Ontology 10
    Phenotypes 10
  • Earliest
    J:18633 Lee CG, et al., Molecular cloning and characterization of a murine LPS-inducible cDNA. J Immunol. 1994 Jun 15;152(12):5758-67
  • Latest
    J:261637 Bambouskova M, et al., Electrophilic properties of itaconate and derivatives regulate the IkappaBzeta-ATF3 inflammatory axis. Nature. 2018 Apr;556(7702):501-504

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
05/22/2019
MGI 6.14
The Jackson Laboratory