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Ptprn
Gene Detail
 Symbol
Name
ID
Ptprn
protein tyrosine phosphatase, receptor type, N
MGI:102765
Synonyms IA-2
Feature Type protein coding gene
Genetic Map
Chromosome 1
38.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:75247027-75264502 bp, - strand
From VEGA annotation of GRCm38

  17476 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48142  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: receptor-type tyrosine-protein phosphatase N-like protein
Gene Tree: Ptprn

Human
homologs
Human Homolog PTPRN, protein tyrosine phosphatase, receptor type, N
NCBI Gene ID 5798
neXtProt AC  NX_Q16849
Human Synonyms  IA2, IA-2, IA-2/PTP, ICA512, R-PTP-N
Human Chr (Location)  2q35-q36.1; chr2:219289623-219309573 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Spontaneous(1) Targeted(4)
Genomic Mutations involving Ptprn (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene on a NOD background display insulitis and increased susceptibility to autoimmune diabetes.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Ptprn interacts with 80 markers (Mir15a, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cytokine-mediated signaling pathway, dephosphorylation, ...
Component integral component of membrane, membrane, ...
Function GTPase binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (101)    Tissues (35)    Images (22)
Theiler Stages: 21, 23, 28
Assay TypeResults
RNA in situ 92
Northern blot 9
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(35) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000048596 (Evidence)
Ensembl Gene ModelENSMUSG00000026204 (Evidence)
Entrez Gene19275 (Evidence)
UniGene2902
DFCITC1575008, TC1591926, TC1704986
DoTSDT.101304078, DT.101399190, DT.50316146, DT.94234744
NIA Mouse Gene IndexU021498
EC3.1.3.48
Consensus CDS ProjectCCDS35625.1
International Mouse Knockout Project StatusPtprn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048596 VEGA Gene Model | MGI Sequence Detail 17476 C57BL/6J ±  kb
transcript OTTMUST00000124490 VEGA | MGI Sequence Detail 3554 Not Applicable 
polypeptide OTTMUSP00000067723 VEGA | MGI Sequence Detail 981 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(6) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR021613 Protein-tyrosine phosphatase receptor IA-2
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013474 receptor-type tyrosine-protein phosphatase-like N
References (Earliest) J:21080 Lu J, et al., Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phosphatase family. Biochem Biophys Res Commun. 1994 Oct 28;204(2):930-6
(Latest) J:210300 Carmona GN, et al., The dense core vesicle protein IA-2, but not IA-2beta, is required for active avoidance learning. Neuroscience. 2014 Jun 6;269:35-42
All references(50)
Other
accession IDs
MGD-MRK-19670

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory