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Ptprn
Gene Detail
Symbol

Name
ID
Ptprn
protein tyrosine phosphatase, receptor type, N
MGI:102765
Synonyms
IA-2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
38.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:75247027-75264502 bp, - strand
From VEGA annotation of GRCm38

  17476 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48142  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PTPRN
Protein SuperFamily: receptor-type tyrosine-protein phosphatase N-like protein
Gene Tree: Ptprn

Human
homologs
PTPRN, protein tyrosine phosphatase, receptor type, N
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5798
neXtProt AC: NX_Q16849

Human Synonyms: IA2, IA-2, IA-2/PTP, ICA512, R-PTP-N

Human Chr (Location): 2q35-q36.1; chr2:219289623-219309573 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Radiation induced(1) Spontaneous(1) Targeted(5)
Genomic Mutations involving Ptprn (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene on a NOD background display insulitis and increased susceptibility to autoimmune diabetes.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Ptprn interacts with 79 markers (Mir15a, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process cytokine-mediated signaling pathway, dense core granule maturation, ...
Component cell, integral component of membrane, ...
Function GTPase binding, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (101)    Tissues (35)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 92
Northern blot 9
cDNA source data(34)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ptprn ; ZFIN ptprna, ptprnb    NEW 
Molecular
reagents
All nucleic(37) cDNA(35) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000048596 (Evidence)
Ensembl Gene Model ENSMUSG00000026204 (Evidence)
Entrez Gene 19275 (Evidence)
UniGene 2902
DFCI TC1704986, TC1591926, TC1575008
DoTS DT.94234744, DT.50316146, DT.101399190, DT.101304078
NIA Mouse Gene Index U021498
EC 3.1.3.48
Consensus CDS Project CCDS35625.1
International Mouse Phenotyping Consortium Status Ptprn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048596 VEGA Gene Model | MGI Sequence Detail 17476 C57BL/6J ±  kb
transcript OTTMUST00000124490 VEGA | MGI Sequence Detail 3554 Not Applicable 
polypeptide OTTMUSP00000067723 VEGA | MGI Sequence Detail 981 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(10) UniProt(12)
Polymorphisms
RFLP(1) : SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR021613 Protein-tyrosine phosphatase receptor IA-2
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
InterPro IPR024833 Regulated endocrine-specific protein 18
Protein Ontology PR:000013474 receptor-type tyrosine-protein phosphatase-like N
References
(Earliest) J:21080 Lu J, et al., Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phosphatase family. Biochem Biophys Res Commun. 1994 Oct 28;204(2):930-6
(Latest) J:210300 Carmona GN, et al., The dense core vesicle protein IA-2, but not IA-2beta, is required for active avoidance learning. Neuroscience. 2014 Jun 6;269:35-42
All references(50)
Other
accession IDs
MGD-MRK-19670

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory