About   Help   FAQ
Ptprn Gene Detail
Summary
  • Symbol
    Ptprn
  • Name
    protein tyrosine phosphatase, receptor type, N
  • Synonyms
    IA-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:102765
    NCBI Gene: 19275
  • Gene Overview
    MyGene.info: PTPRN
Location & Maps
more
  • Sequence Map
    Chr1:75247027-75264502 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17476 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 38.64 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PTPRN, protein tyrosine phosphatase, receptor type N
  • Vertebrate Orthologs
    11
  • Human Ortholog
    PTPRN, protein tyrosine phosphatase, receptor type N
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IA2, IA-2, IA-2/PTP, ICA512, R-PTP-N
  • Links
    NCBI Gene ID: 5798
    neXtProt AC: NX_Q16849

  • Chr Location
    2q35; chr2:219289623-219309573 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Ptprn
  • Incidental Mutations
Mice homozygous for a disruption in this gene on a NOD background display insulitis and increased susceptibility to autoimmune diabetes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048596 VEGA Gene Model | MGI Sequence Detail 17476 C57BL/6J ±  kb
transcript OTTMUST00000124490 VEGA | MGI Sequence Detail 3554 Not Applicable  
polypeptide OTTMUSP00000067723 VEGA | MGI Sequence Detail 981 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    96 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    cDNA 36
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-19670
References
more
  • Summaries
    All 48
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 10
    Phenotypes 32
  • Earliest
    J:21080 Lu J, et al., Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phosphatase family. Biochem Biophys Res Commun. 1994 Oct 28;204(2):930-6
  • Latest
    J:226444 Xu H, et al., The Ia-2beta intronic miRNA, miR-153, is a negative regulator of insulin and dopamine secretion through its effect on the Cacna1c gene in mice. Diabetologia. 2015 Oct;58(10):2298-306

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory