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Nmt1 Gene Detail
Summary
  • Symbol
    Nmt1
  • Name
    N-myristoyltransferase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102579
    NCBI Gene: 18107
  • Gene Overview
    MyGene.info: NMT1
Location & Maps
more
  • Sequence Map
    Chr11:103028190-103068912 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40723 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 66.71 cM, cytoband D
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NMT1, N-myristoyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NMT1, N-myristoyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NMT
  • Links
    NCBI Gene ID: 4836
    neXtProt AC: NX_P30419

  • Chr Location
    17q21.31; chr17:45061283-45109016 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    2
  • Targeted
    4
  • Genomic Mutations
    1 involving Nmt1
  • Incidental Mutations
Homozygous mutation of this gene results in embryonic lethality between E3.5 and E7.5. Heterozygotes show partial prenatal lethality. Mice homozygous for a conditional allele knocked out in T cells exhibit reduced T cell, double positive T cell and single positive T cell numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003161 VEGA Gene Model | MGI Sequence Detail 40723 C57BL/6J ±  kb
transcript OTTMUST00000006539 VEGA | MGI Sequence Detail 4861 Not Applicable  
polypeptide OTTMUSP00000003095 VEGA | MGI Sequence Detail 496 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    227 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000002203 glycylpeptide N-tetradecanoyltransferase 1
  • EC
  • InterPro Domains
    IPR016181 Acyl-CoA N-acyltransferase
    IPR000903 Myristoyl-CoA:protein N-myristoyltransferase
    IPR022678 Myristoyl-CoA:protein N-myristoyltransferase, conserved site
    IPR022677 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal
    IPR022676 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal
Molecular
Reagents
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  • All nucleic 16
    cDNA 12
    Primer pair 3
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-19465, MGI:2144553
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:19094 Hara T, et al., Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. Blood. 1994 Jul 1;84(1):189-99
  • Latest
    J:226234 Rampoldi F, et al., Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation. J Immunol. 2015 Nov 1;195(9):4228-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory