About   Help   FAQ
Nmt1 Gene Detail
Summary
  • Symbol
    Nmt1
  • Name
    N-myristoyltransferase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102579
    NCBI Gene: 18107
  • Gene Overview
    MyGene.info: NMT1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:103028344-103066111 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 66.71 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    223 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102579
protein coding gene Chr11:103028190-103068912 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019253
protein coding gene Chr11:106069412-106114247 (+)
A/J MGP_AJ_G0019221
protein coding gene Chr11:101574105-101619027 (+)
AKR/J MGP_AKRJ_G0019190
protein coding gene Chr11:104713372-104753913 (+)
BALB/cJ MGP_BALBcJ_G0019195
protein coding gene Chr11:102049413-102091751 (+)
C3H/HeJ MGP_C3HHeJ_G0019004
protein coding gene Chr11:104937668-104979518 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019644
protein coding gene Chr11:109361851-109416613 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017270
protein coding gene Chr11:98994386-99036349 (+)
CAST/EiJ MGP_CASTEiJ_G0018558
protein coding gene Chr11:105949510-105990799 (+)
CBA/J MGP_CBAJ_G0018973
protein coding gene Chr11:113908946-113965143 (+)
DBA/2J MGP_DBA2J_G0019085
protein coding gene Chr11:101091916-101131700 (+)
FVB/NJ MGP_FVBNJ_G0019075
protein coding gene Chr11:100634199-100673548 (+)
LP/J MGP_LPJ_G0019154
protein coding gene Chr11:106588612-106633129 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019106
protein coding gene Chr11:113317460-113362037 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019682
protein coding gene Chr11:105094416-105136563 (+)
PWK/PhJ MGP_PWKPhJ_G0018321
protein coding gene Chr11:102161020-102200413 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018113
protein coding gene Chr11:104852654-104894461 (+)
WSB/EiJ MGP_WSBEiJ_G0018607
protein coding gene Chr11:105090053-105136856 (+)



Homology
more
  • Human Ortholog
    NMT1, N-myristoyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NMT1, N-myristoyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NMT
  • Links
    NCBI Gene ID: 4836
    neXtProt AC: NX_P30419
    UniProt: P30419

  • Chr Location
    17q21.31; chr17:45061291-45109016 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality between E3.5 and E7.5. Heterozygotes show partial prenatal lethality. Mice homozygous for a conditional allele knocked out in T cells exhibit reduced T cell, double positive T cell and single positive T cell numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18107 NCBI Gene Model | MGI Sequence Detail 37768 C57BL/6J ±  kb
transcript NM_008707 RefSeq | MGI Sequence Detail 4660 C57BL/6  
polypeptide O70310 UniProt | EBI | MGI Sequence Detail 496 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000002203 glycylpeptide N-tetradecanoyltransferase 1
  • EC
  • InterPro Domains
    IPR016181 Acyl-CoA N-acyltransferase
    IPR000903 Myristoyl-CoA:protein N-myristoyltransferase
    IPR022678 Myristoyl-CoA:protein N-myristoyltransferase, conserved site
    IPR022677 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal
    IPR022676 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal
Molecular
Reagents
less
  • All nucleic 17
    cDNA 13
    Primer pair 3
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-19465, MGI:2144553
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:19094 Hara T, et al., Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. Blood. 1994 Jul 1;84(1):189-99
  • Latest
    J:226234 Rampoldi F, et al., Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation. J Immunol. 2015 Nov 1;195(9):4228-43

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory