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Hbb-ar Other Genome Feature Detail
Summary
  • Symbol
    Hbb-ar
  • Name
    hemoglobin, activating region
  • Synonyms
    HS2, HS3, HS4, HS5, LCR, locus control region
  • Feature Type
    unclassified other genome feature
  • IDs
    MGI:102559
    NCBI Gene: 15128
  • Member of
    Hbb cluster
Location & Maps
more
  • Sequence Map
    Genome coordinates not available
  • Genetic Map
    Chromosome 7, Syntenic
  • Mapping Data
    2 experiments
  • Sequence Tag for
Human Diseases
more
  • Diseases
    1 with Hbb-ar mouse models

Human Disease Mouse Models
       Beta-Thalassemia   OMIM: 613985 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 6 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Targeted
    16
  • Genomic Mutations
    1 involving Hbb-ar
Mice homozygous for various alleles for this exhibit varying effects on Hbb expression.
Sequences &
Gene Models
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  • All Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic AF037169 GenBank | EMBL | DDBJ | MGI Sequence Detail 5794 129/Sv ±  kb
For the selected sequence
Molecular
Reagents
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  • All nucleic 4
    Genomic 4
Other
Accession IDs
less
MGD-MRK-19428
References
more
  • Summaries
    All 23
    Diseases 3
    Phenotypes 12
  • Earliest
    J:22204 Moon AM, et al., Conservation of the primary structure, organization, and function of the human and mouse beta-globin locus-activating regions. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7693-7
  • Latest
    J:214585 Deng W, et al., Reactivation of developmentally silenced globin genes by forced chromatin looping. Cell. 2014 Aug 14;158(4):849-60

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory