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Calcr
Gene Detail
Symbol

Name
ID
Calcr
calcitonin receptor
MGI:101950
Synonyms
Clr
Feature Type
protein coding gene
Genetic Map
Chromosome 6
1.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:3685677-3764713 bp, - strand
From VEGA annotation of GRCm38

  79037 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CALCR
Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Calcr

Human
homologs
CALCR, calcitonin receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 799
neXtProt AC: NX_P30988

Human Synonyms: CRT, CTR, CT-R, CTR1

Human Chr (Location): 7q21.3; chr7:93424487-93574730 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CALCR

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Haploinsufficiency may result in increased bone density due to increased bone formation. Homozygous inactivation may result in embryonic lethality. Mice homozygous for another disruption allele at this locus show a normal phenotype.
 
Interactions
Calcr interacts with 335 markers (Mir1b, Mir7-1, Mir10a, ...)
Expression
Literature Summary: (14 records)
Data Summary: Results (101)    Tissues (64)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 38
RT-PCR 63
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN calcr    NEW 
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(10) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035628 (Evidence)
Ensembl Gene Model ENSMUSG00000023964 (Evidence)
Entrez Gene 12311 (Evidence)
UniGene 4642
DFCI TC1586252, TC1598762
DoTS DT.101347640, DT.110499857, DT.87055426
NIA Mouse Gene Index U027007
Consensus CDS Project CCDS39416.1, CCDS39417.1
International Mouse Phenotyping Consortium Status Calcr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035628 VEGA Gene Model | MGI Sequence Detail 79037 C57BL/6J ±  kb
transcript OTTMUST00000091197 VEGA | MGI Sequence Detail 3758 Not Applicable 
polypeptide OTTMUSP00000050202 VEGA | MGI Sequence Detail 533 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(249 from dbSNP Build 137)    SNPs within 2kb including multiple locations(251)
Protein-related
information
ResourceIDDescription
InterPro IPR001688 GPCR, family 2, calcitonin receptor
InterPro IPR003287 GPCR, family 2, calcitonin receptor family
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000004972 calcitonin receptor
References
(Earliest) J:22084 Yamin M, et al., Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene. Endocrinology. 1994 Dec;135(6):2635-43
(Latest) J:203695 Lieben L, et al., Maternal hypervitaminosis D reduces fetal bone mass and mineral acquisition and leads to neonatal lethality. Bone. 2013 Nov;57(1):123-31
All references(53)
Other
accession IDs
MGD-MRK-18784

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory