Calcr
Gene Detail

Symbol Name ID

Calcr calcitonin receptor MGI:101950

Synonyms

Clr

Feature Type

protein coding gene

Genetic Map

Chromosome 6

1.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:3685677-3764713 bp, - strand From VEGA annotation of GRCm38   79037 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; pig, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Calcr ± 2 cM)

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Calcr

Human ortholog

CALCR calcitonin receptor NCBI Gene ID 799
Human Synonyms: CRT, CTR, CT-R, CTR1
Human Chr7:93053799-93204042 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human CALCR (1)

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Haploinsufficiency may result in increased bone density due to increased bone formation. Homozygous inactivation may result in embryonic lethality. Mice homozygous for another disruption allele at this locus show a normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component	acrosomal vesicle, axon, ...
Function	calcitonin binding, calcitonin receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (103)    Tissues (66)    Images (9)
Theiler Stages: 1, 2, 3, 5, 23, 28

Assay Type	Results
In situ reporter (knock in)	38
RT-PCR	65

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(1) cDNA(10) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035628 (Evidence)
Ensembl Gene Model	ENSMUSG00000023964 (Evidence)
Entrez Gene	12311 (Evidence)
UniGene	4642
DFCI	TC1586252, TC1598762
DoTS	DT.101347640, DT.110499857, DT.87055426
NIA Mouse Gene Index	U027007
Consensus CDS Project	CCDS39416.1, CCDS39417.1
International Mouse Knockout Project Status	Calcr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035628	VEGA Gene Model | MGI Sequence Detail	79037	C57BL/6J
transcript	OTTMUST00000091197	VEGA | MGI Sequence Detail	3758	Not Applicable
polypeptide	OTTMUSP00000050202	VEGA | MGI Sequence Detail	533	Not Applicable

All sequences(61) RefSeq(4) UniProt(5)

Polymorphisms

RFLP(1) : SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001688	GPCR, family 2, calcitonin receptor
InterPro	IPR003287	GPCR, family 2, calcitonin receptor family
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR017983	GPCR, family 2, secretin-like, conserved site
Protein Ontology	PR:000004972	calcitonin receptor

References

(Earliest) J:22084 Yamin M, et al., Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene. Endocrinology. 1994 Dec;135(6):2635-43
(Latest) J:183117 Wookey PJ, et al., Transient expression of the calcitonin receptor by enteric neurons of the embryonic and early post-natal mouse. Cell Tissue Res. 2012 Feb;347(2):311-7
All references(53)

Other accession IDs

MGD-MRK-18784