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Calcr
Gene Detail
Symbol

Name
ID
Calcr
calcitonin receptor
MGI:101950
Synonyms
Clr
Feature Type
protein coding gene
Genetic Map
Chromosome 6
1.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:3685677-3764713 bp, - strand
From VEGA annotation of GRCm38

  79037 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1320  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor, peptide hormone receptor type
Gene Tree: Calcr

Human
homologs
Human Homolog CALCR, calcitonin receptor
NCBI Gene ID 799
neXtProt AC  NX_P30988
Human Synonyms  CRT, CTR, CT-R, CTR1
Human Chr (Location)  7q21.3; chr7:93424487-93574730 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CALCR
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Haploinsufficiency may result in increased bone density due to increased bone formation. Homozygous inactivation may result in embryonic lethality. Mice homozygous for another disruption allele at this locus show a normal phenotype.
 
Interactions
Calcr interacts with 336 markers (Mir1b, Mir7-1, Mir10a, ...)
Expression
Literature Summary: (13 records)
Data Summary: Results (101)    Tissues (64)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 38
RT-PCR 63
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(1) cDNA(10) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035628 (Evidence)
Ensembl Gene ModelENSMUSG00000023964 (Evidence)
Entrez Gene12311 (Evidence)
UniGene4642
DFCITC1586252, TC1598762
DoTSDT.101347640, DT.110499857, DT.87055426
NIA Mouse Gene IndexU027007
Consensus CDS ProjectCCDS39416.1, CCDS39417.1
International Mouse Knockout Project StatusCalcr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035628 VEGA Gene Model | MGI Sequence Detail 79037 C57BL/6J ±  kb
transcript OTTMUST00000091197 VEGA | MGI Sequence Detail 3758 Not Applicable 
polypeptide OTTMUSP00000050202 VEGA | MGI Sequence Detail 533 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(8) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(249 from dbSNP Build 137)    SNPs within 2kb including multiple locations(251)
Protein-related
information
ResourceIDDescription
InterPro IPR001688 GPCR, family 2, calcitonin receptor
InterPro IPR003287 GPCR, family 2, calcitonin receptor family
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
Protein Ontology PR:000004972 calcitonin receptor
References
(Earliest) J:22084 Yamin M, et al., Cloning and characterization of a mouse brain calcitonin receptor complementary deoxyribonucleic acid and mapping of the calcitonin receptor gene. Endocrinology. 1994 Dec;135(6):2635-43
(Latest) J:183117 Wookey PJ, et al., Transient expression of the calcitonin receptor by enteric neurons of the embryonic and early post-natal mouse. Cell Tissue Res. 2012 Feb;347(2):311-7
All references(53)
Other
accession IDs
MGD-MRK-18784

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory