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Tango2 Gene Detail
Summary
  • Symbol
    Tango2
  • Name
    transport and golgi organization 2
  • Synonyms
    D16H22S680E, T10
  • Feature Type
    protein coding gene
  • IDs
    MGI:101825
    NCBI Gene: 27883
  • Gene Overview
    MyGene.info: TANGO2
Location & Maps
more
  • Sequence Map
    Chr16:18300825-18348103 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      47279 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.34 cM, cytoband B1
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    TANGO2, transport and golgi organization 2 homolog
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TANGO2, transport and golgi organization 2 homolog
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C22orf25, MECRCN
  • Links
    NCBI Gene ID: 128989
    neXtProt AC: NX_Q6ICL3

  • Chr Location
    22q11.21; chr22:20017000-20065926 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TANGO2 associations

Human Disease Mouse Models
       Metabolic Encephalomyopathic Crises, Recurrent, with Rhabdomyolysis, Cardiac Arrhythmias, and Neurodegeneration; MECRCN   OMIM: 616878
Click on a disease name to see all genes associated with that disease.

  • References
    12 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    45 phenotype references
  • All Mutations and Alleles
    21
  • Gene trapped
    9
  • Targeted
    12
  • Genomic Mutations
    10 involving Tango2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026022 VEGA Gene Model | MGI Sequence Detail 47279 C57BL/6J ±  kb
transcript OTTMUST00000064221 VEGA | MGI Sequence Detail 1507 Not Applicable  
polypeptide OTTMUSP00000031866 VEGA | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016002 transport and Golgi organization protein 2
  • InterPro Domains
    IPR008551 Transport and Golgi organisation protein 2
Molecular
Reagents
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  • All nucleic 109
    Genomic 25
    cDNA 82
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18644
References
more
  • Summaries
    All 36
    Developmental Gene Expression 6
    Diseases 12
    Gene Ontology 1
    Phenotypes 45
  • Earliest
    J:15242 Halford S, et al., Isolation of a gene expressed during early embryogenesis from the region of 22q11 commonly deleted in DiGeorge syndrome. Hum Mol Genet. 1993 Oct;2(10):1577-82
  • Latest
    J:213451 Karpinski BA, et al., Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome. Dis Model Mech. 2014 Feb;7(2):245-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory