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Tango2 Gene Detail
Summary
  • Symbol
    Tango2
  • Name
    transport and golgi organization 2
  • Synonyms
    D16H22S680E, T10
  • Feature Type
    protein coding gene
  • IDs
    MGI:101825
    NCBI Gene: 27883
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:18118689-18165962 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.34 cM, cytoband B1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101825
 protein coding gene Chr16:18118689-18165967 (-)
129S1/SvImJ ENSMUSG00200046089
 protein coding gene Chr16:15115452-15162732 (-)
A/J ENSMUSG00195034264
 protein coding gene Chr16:14672775-14720059 (-)
AKR/J ENSMUSG00220044905
 protein coding gene Chr16:14989043-15036329 (-)
BALB/cJ ENSMUSG00180039045
 protein coding gene Chr16:14914053-14961337 (-)
C3H/HeJ ENSMUSG00175041444
 protein coding gene Chr16:15059026-15106301 (-)
C57BL/6NJ ENSMUSG00215039535
 protein coding gene Chr16:14780126-14827405 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020543
 protein coding gene Chr16:14789275-14833280 (-)
CAST/EiJ ENSTCUG00005040658
 protein coding gene Chr16:14986163-15033554 (-)
CBA/J ENSMUSG00210041562
 protein coding gene Chr16:15075334-15122609 (-)
DBA/2J ENSMUSG00185030558
 protein coding gene Chr16:15019949-15067228 (-)
FVB/NJ ENSMUSG00205045861
 protein coding gene Chr16:15029460-15076739 (-)
JF1/MsJ ENSUMUG00000051968
 protein coding gene Chr16:15121157-15165160 (-)
LP/J ENSMUSG00230038496
 protein coding gene Chr16:17599369-17646646 (-)
NOD/ShiLtJ ENSMUSG00190041451
 protein coding gene Chr16:15161366-15208642 (-)
NZO/HlLtJ ENSMUSG00225036553
 protein coding gene Chr16:20845177-20892455 (-)
PWK/PhJ ENSLUMG00010041327
 protein coding gene Chr16:15001924-15046271 (-)
SPRET/EiJ ENSMSPG00010037190
 protein coding gene Chr16:15005674-15047520 (-)
WSB/EiJ ENSIUOG00005041396
 protein coding gene Chr16:15154776-15201910 (-)



Homology
more
  • Human Ortholog
    TANGO2, transport and golgi organization 2 homolog
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TANGO2, transport and golgi organization 2 homolog
  • Synonyms
    C22orf25, MECRCN
  • Links
    NCBI Gene ID: 128989
    UniProt: Q6ICL3

  • Chr Location
    22q11.21; chr22:20016615-20067164 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TANGO2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    161 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    666
  • Tissues
    62
  • cDNA Data
    84
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 27883 NCBI Gene Model | MGI Sequence Detail 47274 C57BL/6J ±  kb
    transcript NM_001359110 RefSeq | MGI Sequence Detail 1748 ZRU/MplStud  
    polypeptide P54797 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000016002 transport and Golgi organization protein 2
      (term hierarchy)
    • InterPro Domains
      IPR008551 Transport and Golgi organisation protein 2
    • GlyGen
      P54797 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 111
      Genomic 25
      cDNA 84
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18644
    References
    more
    • Summaries
      All 196
      Developmental Gene Expression 7
      Diseases 6
      Gene Ontology 6
      Phenotypes 161
    • Earliest
      J:15242 Halford S, et al., Isolation of a gene expressed during early embryogenesis from the region of 22q11 commonly deleted in DiGeorge syndrome. Hum Mol Genet. 1993 Oct;2(10):1577-82
    • Latest
      J:390319 Son GY, et al., Dysregulated calcium signaling underlies hyposalivation and microbial dysbiosis in Down syndrome. Cell Rep. 2026 Jul 1;:117619
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory