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Tlag1 QTL Detail
Summary
  • Symbol
    Tlag1
  • Name
    T lymphoma attenuation gene 1
  • Synonyms
    Tls1, Tls-1
  • Feature Type
    QTL
  • IDs
    MGI:101804
    NCBI Gene: 110137
Location &
Maps
more
  • Sequence Map
    Chr7:87073979-87142720 bp
    From MGI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, cM position of peak correlated region/marker: Syntenic
  • Mapping Data
    2 experiments
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from multigenic genotypes
    2 phenotype references
MNU treated AKR/J mice develop a high incidence of thymic lymphomas at 6 weeks of age, a significant acceleration over spontaneous occurrence. C57BL/J mice do not develop thymic lymphomas, and only at a low rate if MNU treated. Crosses indicate several genes may contribute, one of which is Tlag1.
Sequences &
Gene Models
less
Other
Accession IDs
less
MGD-MRK-15134, MGD-MRK-15135, MGD-MRK-18616
References
more
  • Summaries
    All 7
    Phenotypes 2
  • Earliest
    J:10061 Angel JM, et al., Genetics of N-methyl-N-nitrosourea induction of thymic lymphomas in AKR/J mice: assignment of a susceptibility gene to mouse chromosome 7. J Natl Cancer Inst. 1989 Nov 1;81(21):1652-5
  • Latest
    J:74369 Angel JM, et al., Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4. Mol Carcinog. 2002 Feb;33(2):105-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/28/2022
MGI 6.20
The Jackson Laboratory