Snta1
Gene Detail

Symbol Name ID

Snta1 syntrophin, acidic 1 MGI:101772

Synonyms

alpha1-syntrophin, Snt1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

76.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:154376313-154408099 bp, - strand From VEGA annotation of GRCm38   31787 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2331  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Snta1

Human homologs

Human Homolog		SNTA1, syntrophin, alpha 1
NCBI Gene ID		6640
neXtProt AC		NX_Q13424
Human Synonyms		dJ1187J4.5, LQT12, SNT1, TACIP1
Human Chr (Location)		20q11.2; chr20:31995763-32031698 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SNTA1

Alleles and phenotypes

All alleles(15) : Targeted(3) Gene trapped(12)
 

Mice homozygous for a targeted null allele display impaired astrocyte and neuromuscular synapse morphology. Mice homozygous for another targeted null allele show neither gross histological abnormalities in skeletal muscle nor significant changes in muscle contractile properties.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	neuromuscular junction development, regulation of vasoconstriction by circulating norepinephrine
Component	cell junction, cytoplasm, ...
Function	actin binding, calmodulin binding, ...

External Resources: FuncBase

Expression

cDNA source data(38)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) Genomic(1) cDNA(41)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000015793 (Evidence)
Ensembl Gene Model	ENSMUSG00000027488 (Evidence)
Entrez Gene	20648 (Evidence)
UniGene	1541
DFCI	TC1580460
DoTS	DT.489825, DT.55261874, DT.94300440
NIA Mouse Gene Index	U023522
PDB	1QAV, 2ADZ, 2PDZ, 1Z86, 1Z87
Consensus CDS Project	CCDS50763.1
International Mouse Knockout Project Status	Snta1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015793	VEGA Gene Model | MGI Sequence Detail	31787	C57BL/6J
transcript	OTTMUST00000037560	VEGA | MGI Sequence Detail	2125	Not Applicable
polypeptide	OTTMUSP00000016832	VEGA | MGI Sequence Detail	503	Not Applicable

All sequences(35) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(126 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001478	PDZ domain
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR015482	Syntrophin
Protein Ontology	PR:000015350	alpha-1-syntrophin

References

(Earliest) J:20636 Adams ME, et al., Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution. Neuron. 1993 Sep;11(3):531-40
(Latest) J:187957 Enger R, et al., Molecular scaffolds underpinning macroglial polarization: An analysis of retinal Muller cells and brain astrocytes in mouse. Glia. 2012 Dec;60(12):2018-26
All references(69)

Other accession IDs

MGD-MRK-14479, MGD-MRK-18579, MGI:2139331