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Snta1
Gene Detail
Symbol

Name
ID
Snta1
syntrophin, acidic 1
MGI:101772
Synonyms
alpha1-syntrophin, Snt1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
76.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:154376313-154408099 bp, - strand
From VEGA annotation of GRCm38

  31787 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2331  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Snta1

Human
homologs
Human Homolog SNTA1, syntrophin, alpha 1
NCBI Gene ID 6640
neXtProt AC  NX_Q13424
Human Synonyms  dJ1187J4.5, LQT12, SNT1, TACIP1
Human Chr (Location)  20q11.2; chr20:33407957-33443892 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SNTA1
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null allele display impaired astrocyte and neuromuscular synapse morphology. Mice homozygous for another targeted null allele show neither gross histological abnormalities in skeletal muscle nor significant changes in muscle contractile properties.
 
Phenotype Images(2)
Interactions
Snta1 interacts with 101 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process negative regulation of peptidyl-cysteine S-nitrosylation, neuromuscular junction development, ...
Component cell junction, cytoplasm, ...
Function actin binding, ATPase binding, ...
External Resources: FuncBase
Expression
cDNA source data(38)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) Genomic(1) cDNA(41)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000015793 (Evidence)
Ensembl Gene ModelENSMUSG00000027488 (Evidence)
Entrez Gene20648 (Evidence)
UniGene1541
DFCITC1580460
DoTSDT.489825, DT.55261874, DT.94300440
NIA Mouse Gene IndexU023522
PDB1Z86, 1Z87, 4HOP, 2ADZ, 2PDZ, 1QAV
Consensus CDS ProjectCCDS50763.1
International Mouse Knockout Project StatusSnta1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015793 VEGA Gene Model | MGI Sequence Detail 31787 C57BL/6J ±  kb
transcript OTTMUST00000037560 VEGA | MGI Sequence Detail 2125 Not Applicable 
polypeptide OTTMUSP00000016832 VEGA | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(164 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR015482 Syntrophin
Protein Ontology PR:000015350 alpha-1-syntrophin
References
(Earliest) J:20636 Adams ME, et al., Two forms of mouse syntrophin, a 58 kd dystrophin-associated protein, differ in primary structure and tissue distribution. Neuron. 1993 Sep;11(3):531-40
(Latest) J:204290 Dmytrenko L, et al., The impact of alpha-syntrophin deletion on the changes in tissue structure and extracellular diffusion associated with cell swelling under physiological and pathological conditions. PLoS One. 2013;8(7):e68044
All references(73)
Other
accession IDs
MGD-MRK-14479, MGD-MRK-18579, MGI:2139331

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory