Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  3
• Reference
  J:33172 Yui MA, et al., Production of congenic mouse strains carrying NOD-derived diabetogenic genetic intervals: an approach for the genetic dissection of complex traits. Mamm Genome. 1996 May;7(5):331-4
• ID
  MGI:46667

Genes

Gene	Assay Type
Idd3	resistance/susceptibility
Idd10	resistance/susceptibility
D3Mit132	PCR amplified length variant
Il2	reported elsewhere
D3Nds1	reported elsewhere
Tshb	reported elsewhere

Notes

• Experiment
  Microsatellite sequences were used as co-dominant markers to identify/map NOD mouse intervals containing recessive susceptibility alleles of insulin-related diabetes-associated genes. These intervals were transferred to C57BL/6, a resistant strain background, to produce 6 congenic strains. A gain of phenotype strategy was used in their construction. B6.NODc3 mice contain intervals Idd3 (Il2) and Idd10 (Tshb); the order of associated markers was reported as D3Mit132 - Il2 - D3Nds1 - Tshb over a distance of 43 cM on mouse Chromosome 3.