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Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    16
  • Reference
    J:153398 Yuan Z, et al., Quantitative trait locus analysis of circulating adhesion molecules in hyperlipidemic apolipoprotein E-deficient mice. Mol Genet Genomics. 2008 Nov;280(5):375-83
  • ID
    MGI:4415238
Genes
GeneAlleleAssay TypeDescription
Ppsl
D16Mit165
Notes
  • Experiment
    C57BL/6J mice display higher VCAM-1 levels then resistant strain C3H/HeJ and BALB/c. Soluble P-selectin levels are also higher in B6.apoE-/- then in BALB/c apoE-/- A total of 234 female animals from a (B6.129P2-Apoetm1Unc/J x C3.129P2(B6)-Apoetm1Unc)F2 intercross facilitated the QTL mapping of these levels in a genome wide scan . The cross is detailed in J:106521 Su Z, Genetics 2006 Mar;172(3):1799-807. Pvacm1l mapped to mouse Chromosome 9 with a peak LOD of 3.9 at D9Mit18. Genetic control of plasma VCAM-1 levels also showed suggestive loci on chromosomes 5, 13 and 15. Ppsl showed a peak at D16Mit165 with a LOD of 3.4. For soluble P-selectin levels suggestive loci were indicated in mouse Chromosomes 10 and 13. A peak cM of 71 cM and 8.5 cM was suggested for Pvacm1l and Ppsl respectively.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory