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Mapping Data
Experiment
  • Experiment
    TEXT-QTL
  • Chromosome
    2
  • Reference
    J:123467 Li X, et al., Chromosomal regions harboring genes for the work to femur failure in mice. Funct Integr Genomics. 2002 Apr;1(6):367-74
  • ID
    MGI:3720852
Genes
GeneAlleleAssay TypeDescription
D2Mit62 PCR amplified length variant
Fmn1 reported elsewhere
Femwf4 visible phenotype
D2Mit44 PCR amplified length variant
Femwf14 visible phenotype yes
Notes
  • Experiment
    Linkage analysis was performed on 633 (MRL/MpJ x SJL/J)F2 female animals at 7 weeks of age to identify genetic loci associated with femur work to failure. A panel of 119 polymorphic markers spaced 12 cM apart was used for genome scan. Parental strain MRL/MpJ displays significantly increased work to failure values compared to parental strain SJL/J. A total of 5 significant QTLs and 1 suggestive QTL were mapped and accounted for 20.7% of the phenotypic variance. After adjusting for periosteal circumference, the 5 major QTLs retained significant association to femur work to failure.

    Significant linkage to femur work to failure mapped to 54.6 cM on mouse Chromosome 2 near D2Mit62 (LOD=8.4). This locus accounts for 7.1% of the variance and overlaps with femur breaking strength QTL Fembrs1. A potential candidate gene for Fembrs1 is Fmn1 at 65 cM.

    Curator Note 12.30.2014: We have named this femur work to failure QTL mapping to Chr 2 near D2Mit62 (LOD=8.4) as Femwf14, to identify it as a significant and unique QTL.

    A novel QTL was detected at 14.4 cM on mouse Chromosome X near DXMit208 (LOD=3.8). This locus accounts for 3.3% of the variance and is named Femwf1 (femur work to failure 1).

    Significant linkage to femur work to failure mapped to 20.7 cM on mouseChromosome 8 near D8Mit125 (LOD=3.7) and colocalizes with Fembrs2. This QTL explains 2.9% of the phenotypic variance.

    Curator Note 12.30.2014: We have named this femur work to failure QTL on Chr 8 as Femwf15, to identify it as a significant and unique QTL.

    A novel QTL for femur work to failure was identified at 31.2 cM on mouse Chromosome 7 near D7Mit232 (LOD=2.8). This locus explains 2.8% of the variance and is named Femwf2 (femur work to failure 2).

    Significant linkage to femur work to failure mappedto 46.5 cM on mouse Chromosome9 near D9Mit270 (LOD=2.1). This locus explains 1.8% of the variance and colocalizes with bone mineral density QTL Bmd10 (48 cM).

    Curator Note 12.30.2014: We have named this femur work to failure QTL on Chr 9 as Femwf16, to identify it as a significant and unique QTL.

    Suggestive linkage to femur work to failure mapped to 6.6 cM on mouse Chromosome 17 (LOD=2.1). This locus colocalizes with femur breaking strength QTL Fembrs4.

    Several interacting loci were also detected by 2-way analysis. Femwf3 (51 cM, D10Mit95) on mouse Chromosome 10 interacts with Femwf4 (47.5 cM, D2Mit44), Femwf5 (49.8 cM, D7Mit44), and Femwf6 (47.6 cM, D11Mit36). These interactions explain 8.9% of the variance.

    Femwf7 (101.5 cM, D1Mit291) on mouse Chromosome 1 interacts with Femwf8(15 cM, D7Mit246) and Femwf9 (2 cM, D12Mit182). These interactions explain 7.3% of the variance.

    Femwf10 (15.4 cM, D15Mit138) on mouseChromosome 15 interacts with Femwf11 (43 cM, D19Mit53) on mouse Chromosome 19. This interaction explains 3.1% of the variance.

    Femwf12 (81.6 cM,D1Mit33) on mouse Chromosome 1 interacts with Femwf13 (61.9 cM, D4Mit204) on mouse Chromosome 4. This interaction explains 3.4% of the variance.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/13/2022
MGI 6.21
The Jackson Laboratory