Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.
On mouse Chromosome 4, linkage to liver weight, Org3 (organ weight 3), mapped to 21 cM near D4Mit163 (LPR=4.01). The confidence interval spans 8 cM - 28 cM.
Linkage to organ weight and bone length, Bod2 (bone length and organs 2), mapped to D4Mit17 (LPR=12.94). This locus affects necropsy body weight, spleen and kidney weights, and all 4 long bone measurements. The confidence interval spans 30 cM - 64 cM. Potential candidate genes mapping near Bod2 include Megf9 (formerly Egfl5), Trim32 (33 cM), and Tyrp1 (38 cM).