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Mapping Data
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  • Reference
    J:85793 Bomar JM, et al., Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse. (Erratum). Nat Genet. 2003 Nov;35(3):264-9
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  • Experiment
    The mouse jittery locus was fine mapped using approximately 3,000 animals from an F2 intercross between CAST/Ei and JIGR/DnJ-Atcayji gr. Animals were typed for markers between an interval defined by D10Mit140 and D10Mit207. The jittery interval was narrowed to an 800 kb region that is orthologous to an interval on human Chromosome 19p13.3 associated with Cayman ataxia. The order of genes in the mouse jittery critical region on chromosome 10 is as follows:

    cent - D10Mit7 - Map2k2/D10Wad2 - Dapk3 - Atcay - Mrpl54 - Gna15 - tel

    Southern blot analysis of genes within the jittery interval identified one particular gene showing DNA changes in jittery mutants. Sequence analysis showed that 3 different jittery mutants (jittery, hesitant, and sidewinder) allcarry mutations in this gene. This gene is Atcay.

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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